Primary Motor Cortex Organization Is Altered in Persistent Patellofemoral Pain

Maxine Te, Abrahão F Baptista, Lucy S Chipchase, Siobhan M Schabrun

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Objective: Reorganization of the primary motor cortex (M1) may be a feature of persistent patellofemoral pain (PFP), but no studies have investigated M1 organization in this condition. Here we aimed to examine the organization of the M1 representation of the quadriceps muscles in people with PFP and healthy controls.

Design: Using a cross-sectional design, the M1 representation of the rectus femoris, vastus lateralis, and vastus medialis was mapped using transcranial magnetic stimulation in 11 individuals with PFP and 11 controls. Measures of pain severity were also made.

Results: Individuals with PFP had reduced map volumes (P < 0.001) and an anterior shift in the M1 representation (P = 0.03) across all three quadriceps muscles compared with controls. Greater overlap of the M1 representation (P = 0.02) and a reduction in the number of discrete cortical peaks (P = 0.009) across all three quadriceps muscles were also observed in individuals with PFP compared with controls. There was no relationship between altered M1 organization and pain in PFP.

Conclusions: These findings provide evidence of altered M1 organization in individuals with PFP compared with healthy controls. Notably, no difference in M1 organization was observed for the medial and lateral heads of the quadriceps in PFP. These data have relevance for our understanding of the pathophysiology of PFP and for the design of future treatments that aim to target M1 in this condition.

Original languageEnglish
Pages (from-to)2224-2234
Number of pages11
JournalPain Medicine (United States)
Volume18
Issue number11
DOIs
Publication statusPublished - 1 Nov 2017
Externally publishedYes

Fingerprint

Motor Cortex
Pain
Quadriceps Muscle
Transcranial Magnetic Stimulation

Cite this

Te, Maxine ; Baptista, Abrahão F ; Chipchase, Lucy S ; Schabrun, Siobhan M. / Primary Motor Cortex Organization Is Altered in Persistent Patellofemoral Pain. In: Pain Medicine (United States). 2017 ; Vol. 18, No. 11. pp. 2224-2234.
@article{2140287b2b53484b8f64d8ddbf63306c,
title = "Primary Motor Cortex Organization Is Altered in Persistent Patellofemoral Pain",
abstract = "Objective: Reorganization of the primary motor cortex (M1) may be a feature of persistent patellofemoral pain (PFP), but no studies have investigated M1 organization in this condition. Here we aimed to examine the organization of the M1 representation of the quadriceps muscles in people with PFP and healthy controls.Design: Using a cross-sectional design, the M1 representation of the rectus femoris, vastus lateralis, and vastus medialis was mapped using transcranial magnetic stimulation in 11 individuals with PFP and 11 controls. Measures of pain severity were also made.Results: Individuals with PFP had reduced map volumes (P < 0.001) and an anterior shift in the M1 representation (P = 0.03) across all three quadriceps muscles compared with controls. Greater overlap of the M1 representation (P = 0.02) and a reduction in the number of discrete cortical peaks (P = 0.009) across all three quadriceps muscles were also observed in individuals with PFP compared with controls. There was no relationship between altered M1 organization and pain in PFP.Conclusions: These findings provide evidence of altered M1 organization in individuals with PFP compared with healthy controls. Notably, no difference in M1 organization was observed for the medial and lateral heads of the quadriceps in PFP. These data have relevance for our understanding of the pathophysiology of PFP and for the design of future treatments that aim to target M1 in this condition.",
keywords = "Journal Article",
author = "Maxine Te and Baptista, {Abrah{\~a}o F} and Chipchase, {Lucy S} and Schabrun, {Siobhan M}",
year = "2017",
month = "11",
day = "1",
doi = "10.1093/pm/pnx036",
language = "English",
volume = "18",
pages = "2224--2234",
journal = "Pain Medicine (United States)",
issn = "1526-2375",
publisher = "VICER Publishing",
number = "11",

}

Te, M, Baptista, AF, Chipchase, LS & Schabrun, SM 2017, 'Primary Motor Cortex Organization Is Altered in Persistent Patellofemoral Pain', Pain Medicine (United States), vol. 18, no. 11, pp. 2224-2234. https://doi.org/10.1093/pm/pnx036

Primary Motor Cortex Organization Is Altered in Persistent Patellofemoral Pain. / Te, Maxine; Baptista, Abrahão F; Chipchase, Lucy S; Schabrun, Siobhan M.

In: Pain Medicine (United States), Vol. 18, No. 11, 01.11.2017, p. 2224-2234.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Primary Motor Cortex Organization Is Altered in Persistent Patellofemoral Pain

AU - Te, Maxine

AU - Baptista, Abrahão F

AU - Chipchase, Lucy S

AU - Schabrun, Siobhan M

PY - 2017/11/1

Y1 - 2017/11/1

N2 - Objective: Reorganization of the primary motor cortex (M1) may be a feature of persistent patellofemoral pain (PFP), but no studies have investigated M1 organization in this condition. Here we aimed to examine the organization of the M1 representation of the quadriceps muscles in people with PFP and healthy controls.Design: Using a cross-sectional design, the M1 representation of the rectus femoris, vastus lateralis, and vastus medialis was mapped using transcranial magnetic stimulation in 11 individuals with PFP and 11 controls. Measures of pain severity were also made.Results: Individuals with PFP had reduced map volumes (P < 0.001) and an anterior shift in the M1 representation (P = 0.03) across all three quadriceps muscles compared with controls. Greater overlap of the M1 representation (P = 0.02) and a reduction in the number of discrete cortical peaks (P = 0.009) across all three quadriceps muscles were also observed in individuals with PFP compared with controls. There was no relationship between altered M1 organization and pain in PFP.Conclusions: These findings provide evidence of altered M1 organization in individuals with PFP compared with healthy controls. Notably, no difference in M1 organization was observed for the medial and lateral heads of the quadriceps in PFP. These data have relevance for our understanding of the pathophysiology of PFP and for the design of future treatments that aim to target M1 in this condition.

AB - Objective: Reorganization of the primary motor cortex (M1) may be a feature of persistent patellofemoral pain (PFP), but no studies have investigated M1 organization in this condition. Here we aimed to examine the organization of the M1 representation of the quadriceps muscles in people with PFP and healthy controls.Design: Using a cross-sectional design, the M1 representation of the rectus femoris, vastus lateralis, and vastus medialis was mapped using transcranial magnetic stimulation in 11 individuals with PFP and 11 controls. Measures of pain severity were also made.Results: Individuals with PFP had reduced map volumes (P < 0.001) and an anterior shift in the M1 representation (P = 0.03) across all three quadriceps muscles compared with controls. Greater overlap of the M1 representation (P = 0.02) and a reduction in the number of discrete cortical peaks (P = 0.009) across all three quadriceps muscles were also observed in individuals with PFP compared with controls. There was no relationship between altered M1 organization and pain in PFP.Conclusions: These findings provide evidence of altered M1 organization in individuals with PFP compared with healthy controls. Notably, no difference in M1 organization was observed for the medial and lateral heads of the quadriceps in PFP. These data have relevance for our understanding of the pathophysiology of PFP and for the design of future treatments that aim to target M1 in this condition.

KW - Journal Article

U2 - 10.1093/pm/pnx036

DO - 10.1093/pm/pnx036

M3 - Article

VL - 18

SP - 2224

EP - 2234

JO - Pain Medicine (United States)

JF - Pain Medicine (United States)

SN - 1526-2375

IS - 11

ER -