Primary sensory and motor cortex excitability are co-modulated in response to peripheral electrical nerve stimulation

Siobhan M Schabrun, Michael C Ridding, Mary P Galea, Paul W Hodges, Lucinda S Chipchase

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Peripheral electrical stimulation (PES) is a common clinical technique known to induce changes in corticomotor excitability; PES applied to induce a tetanic motor contraction increases, and PES at sub-motor threshold (sensory) intensities decreases, corticomotor excitability. Understanding of the mechanisms underlying these opposite changes in corticomotor excitability remains elusive. Modulation of primary sensory cortex (S1) excitability could underlie altered corticomotor excitability with PES. Here we examined whether changes in primary sensory (S1) and motor (M1) cortex excitability follow the same time-course when PES is applied using identical stimulus parameters. Corticomotor excitability was measured using transcranial magnetic stimulation (TMS) and sensory cortex excitability using somatosensory evoked potentials (SEPs) before and after 30 min of PES to right abductor pollicis brevis (APB). Two PES paradigms were tested in separate sessions; PES sufficient to induce a tetanic motor contraction (30-50 Hz; strong motor intensity) and PES at sub motor-threshold intensity (100 Hz). PES applied to induce strong activation of APB increased the size of the N(20)-P(25) component, thought to reflect sensory processing at cortical level, and increased corticomotor excitability. PES at sensory intensity decreased the size of the P25-N33 component and reduced corticomotor excitability. A positive correlation was observed between the changes in amplitude of the cortical SEP components and corticomotor excitability following sensory and motor PES. Sensory PES also increased the sub-cortical P(14)-N(20) SEP component. These findings provide evidence that PES results in co-modulation of S1 and M1 excitability, possibly due to cortico-cortical projections between S1 and M1. This mechanism may underpin changes in corticomotor excitability in response to afferent input generated by PES.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalPLoS One
Volume7
Issue number12
DOIs
Publication statusPublished - 2012
Externally publishedYes

Fingerprint

Motor Cortex
Peripheral Nerves
Electric Stimulation
nerve tissue
evoked potentials
Bioelectric potentials
cortex
Somatosensory Evoked Potentials
Modulation
Sensorimotor Cortex
motor cortex
Chemical activation
Sensory Thresholds
Transcranial Magnetic Stimulation
Processing

Cite this

Schabrun, Siobhan M ; Ridding, Michael C ; Galea, Mary P ; Hodges, Paul W ; Chipchase, Lucinda S. / Primary sensory and motor cortex excitability are co-modulated in response to peripheral electrical nerve stimulation. In: PLoS One. 2012 ; Vol. 7, No. 12. pp. 1-7.
@article{eec3fc53568a4235abb193a7a9f133a0,
title = "Primary sensory and motor cortex excitability are co-modulated in response to peripheral electrical nerve stimulation",
abstract = "Peripheral electrical stimulation (PES) is a common clinical technique known to induce changes in corticomotor excitability; PES applied to induce a tetanic motor contraction increases, and PES at sub-motor threshold (sensory) intensities decreases, corticomotor excitability. Understanding of the mechanisms underlying these opposite changes in corticomotor excitability remains elusive. Modulation of primary sensory cortex (S1) excitability could underlie altered corticomotor excitability with PES. Here we examined whether changes in primary sensory (S1) and motor (M1) cortex excitability follow the same time-course when PES is applied using identical stimulus parameters. Corticomotor excitability was measured using transcranial magnetic stimulation (TMS) and sensory cortex excitability using somatosensory evoked potentials (SEPs) before and after 30 min of PES to right abductor pollicis brevis (APB). Two PES paradigms were tested in separate sessions; PES sufficient to induce a tetanic motor contraction (30-50 Hz; strong motor intensity) and PES at sub motor-threshold intensity (100 Hz). PES applied to induce strong activation of APB increased the size of the N(20)-P(25) component, thought to reflect sensory processing at cortical level, and increased corticomotor excitability. PES at sensory intensity decreased the size of the P25-N33 component and reduced corticomotor excitability. A positive correlation was observed between the changes in amplitude of the cortical SEP components and corticomotor excitability following sensory and motor PES. Sensory PES also increased the sub-cortical P(14)-N(20) SEP component. These findings provide evidence that PES results in co-modulation of S1 and M1 excitability, possibly due to cortico-cortical projections between S1 and M1. This mechanism may underpin changes in corticomotor excitability in response to afferent input generated by PES.",
keywords = "Adult, Electric Stimulation, Evoked Potentials, Somatosensory, Female, Humans, Linear Models, Male, Motor Activity, Motor Cortex, Peripheral Nerves, Somatosensory Cortex, Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't",
author = "Schabrun, {Siobhan M} and Ridding, {Michael C} and Galea, {Mary P} and Hodges, {Paul W} and Chipchase, {Lucinda S}",
year = "2012",
doi = "10.1371/journal.pone.0051298",
language = "English",
volume = "7",
pages = "1--7",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "12",

}

Primary sensory and motor cortex excitability are co-modulated in response to peripheral electrical nerve stimulation. / Schabrun, Siobhan M; Ridding, Michael C; Galea, Mary P; Hodges, Paul W; Chipchase, Lucinda S.

In: PLoS One, Vol. 7, No. 12, 2012, p. 1-7.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Primary sensory and motor cortex excitability are co-modulated in response to peripheral electrical nerve stimulation

AU - Schabrun, Siobhan M

AU - Ridding, Michael C

AU - Galea, Mary P

AU - Hodges, Paul W

AU - Chipchase, Lucinda S

PY - 2012

Y1 - 2012

N2 - Peripheral electrical stimulation (PES) is a common clinical technique known to induce changes in corticomotor excitability; PES applied to induce a tetanic motor contraction increases, and PES at sub-motor threshold (sensory) intensities decreases, corticomotor excitability. Understanding of the mechanisms underlying these opposite changes in corticomotor excitability remains elusive. Modulation of primary sensory cortex (S1) excitability could underlie altered corticomotor excitability with PES. Here we examined whether changes in primary sensory (S1) and motor (M1) cortex excitability follow the same time-course when PES is applied using identical stimulus parameters. Corticomotor excitability was measured using transcranial magnetic stimulation (TMS) and sensory cortex excitability using somatosensory evoked potentials (SEPs) before and after 30 min of PES to right abductor pollicis brevis (APB). Two PES paradigms were tested in separate sessions; PES sufficient to induce a tetanic motor contraction (30-50 Hz; strong motor intensity) and PES at sub motor-threshold intensity (100 Hz). PES applied to induce strong activation of APB increased the size of the N(20)-P(25) component, thought to reflect sensory processing at cortical level, and increased corticomotor excitability. PES at sensory intensity decreased the size of the P25-N33 component and reduced corticomotor excitability. A positive correlation was observed between the changes in amplitude of the cortical SEP components and corticomotor excitability following sensory and motor PES. Sensory PES also increased the sub-cortical P(14)-N(20) SEP component. These findings provide evidence that PES results in co-modulation of S1 and M1 excitability, possibly due to cortico-cortical projections between S1 and M1. This mechanism may underpin changes in corticomotor excitability in response to afferent input generated by PES.

AB - Peripheral electrical stimulation (PES) is a common clinical technique known to induce changes in corticomotor excitability; PES applied to induce a tetanic motor contraction increases, and PES at sub-motor threshold (sensory) intensities decreases, corticomotor excitability. Understanding of the mechanisms underlying these opposite changes in corticomotor excitability remains elusive. Modulation of primary sensory cortex (S1) excitability could underlie altered corticomotor excitability with PES. Here we examined whether changes in primary sensory (S1) and motor (M1) cortex excitability follow the same time-course when PES is applied using identical stimulus parameters. Corticomotor excitability was measured using transcranial magnetic stimulation (TMS) and sensory cortex excitability using somatosensory evoked potentials (SEPs) before and after 30 min of PES to right abductor pollicis brevis (APB). Two PES paradigms were tested in separate sessions; PES sufficient to induce a tetanic motor contraction (30-50 Hz; strong motor intensity) and PES at sub motor-threshold intensity (100 Hz). PES applied to induce strong activation of APB increased the size of the N(20)-P(25) component, thought to reflect sensory processing at cortical level, and increased corticomotor excitability. PES at sensory intensity decreased the size of the P25-N33 component and reduced corticomotor excitability. A positive correlation was observed between the changes in amplitude of the cortical SEP components and corticomotor excitability following sensory and motor PES. Sensory PES also increased the sub-cortical P(14)-N(20) SEP component. These findings provide evidence that PES results in co-modulation of S1 and M1 excitability, possibly due to cortico-cortical projections between S1 and M1. This mechanism may underpin changes in corticomotor excitability in response to afferent input generated by PES.

KW - Adult

KW - Electric Stimulation

KW - Evoked Potentials, Somatosensory

KW - Female

KW - Humans

KW - Linear Models

KW - Male

KW - Motor Activity

KW - Motor Cortex

KW - Peripheral Nerves

KW - Somatosensory Cortex

KW - Clinical Trial

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1371/journal.pone.0051298

DO - 10.1371/journal.pone.0051298

M3 - Article

VL - 7

SP - 1

EP - 7

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 12

ER -