Principles of 3D chromosome folding and evolutionary genome reshuffling in mammals

Lucía Álvarez-González, Cristina Arias-Sardá, Laia Montes-Espuña, Laia Marín-Gual, Covadonga Vara, Nicholas C. Lister, Yasmina Cuartero, Francisca Garcia, Janine Deakin, Marilyn B. Renfree, Terence J. Robinson, Marc A. Martí-Renom, Paul D. Waters, Marta Farré, Aurora Ruiz-Herrera

Research output: Contribution to journalArticlepeer-review

Abstract

Studying the similarities and differences in genomic interactions between species provides fertile grounds for determining the evolutionary dynamics underpinning genome function and speciation. Here, we describe the principles of 3D genome folding in vertebrates and show how lineage-specific patterns of genome reshuffling can result in different chromatin configurations. We (1) identified different patterns of chromosome folding in across vertebrate species (centromere clustering versus chromosomal territories); (2) reconstructed ancestral marsupial and afrotherian genomes analyzing whole-genome sequences of species representative of the major therian phylogroups; (3) detected lineage-specific chromosome rearrangements; and (4) identified the dynamics of the structural properties of genome reshuffling through therian evolution. We present evidence of chromatin configurational changes that result from ancestral inversions and fusions/fissions. We catalog the close interplay between chromatin higher-order organization and therian genome evolution and introduce an interpretative hypothesis that explains how chromatin folding influences evolutionary patterns of genome reshuffling.

Original languageEnglish
Article number111839
Pages (from-to)1-25
Number of pages25
JournalCell Reports
Volume41
Issue number12
DOIs
Publication statusPublished - 20 Dec 2022

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