Prior exposure to non-pathogenic calicivirus RCV-A1 reduces both infection rate and mortality from rabbit haemorrhagic disease in a population of wild rabbits in Australia

B. D. Cooke, R. P. Duncan, I. Mcdonald, J. Liu, L. Capucci, G. J. Mutze, T. Strive

    Research output: Contribution to journalArticle

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    Abstract

    Mortality caused by rabbit haemorrhagic disease virus (RHDV) in wild rabbits is reduced in parts of Australia where the related, non-pathogenic calicivirus RCV-A1 is endemic. Laboratory experiments previously showed that prior infection with RCV-A1 enabled rabbits to better withstand subsequent infection with highly virulent RHDV, and this was assumed to explain higher survival. Here, we analyse serological data from the field suggesting that reduced mortality rates among wild rabbits may also result from rabbits previously infected with RCV-A1 having a reduced likelihood of RHDV infection. We discuss the possible mechanisms underlying this finding and its implications. The methods we describe for analysing field data gave far greater insights into epidemiological processes and virus interactions than gained from reporting basic seroprevalence rates alone.

    Original languageEnglish
    Pages (from-to)470-477
    Number of pages8
    JournalTransboundary and Emerging Diseases
    Volume65
    Issue number2
    DOIs
    Publication statusPublished - Apr 2018

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    Vesivirus
    Rabbit Haemorrhagic Disease Virus
    Rabbit hemorrhagic disease virus
    rabbits
    Rabbits
    Mortality
    Infection
    infection
    Population
    Seroepidemiologic Studies
    Virus Diseases
    seroprevalence
    Viruses
    viruses

    Cite this

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    title = "Prior exposure to non-pathogenic calicivirus RCV-A1 reduces both infection rate and mortality from rabbit haemorrhagic disease in a population of wild rabbits in Australia",
    abstract = "Mortality caused by rabbit haemorrhagic disease virus (RHDV) in wild rabbits is reduced in parts of Australia where the related, non-pathogenic calicivirus RCV-A1 is endemic. Laboratory experiments previously showed that prior infection with RCV-A1 enabled rabbits to better withstand subsequent infection with highly virulent RHDV, and this was assumed to explain higher survival. Here, we analyse serological data from the field suggesting that reduced mortality rates among wild rabbits may also result from rabbits previously infected with RCV-A1 having a reduced likelihood of RHDV infection. We discuss the possible mechanisms underlying this finding and its implications. The methods we describe for analysing field data gave far greater insights into epidemiological processes and virus interactions than gained from reporting basic seroprevalence rates alone.",
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    author = "Cooke, {B. D.} and Duncan, {R. P.} and I. Mcdonald and J. Liu and L. Capucci and Mutze, {G. J.} and T. Strive",
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    journal = "Journal of Veterinary Medicine Series A: Physiology Pathology Clinical Medicine",
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    Prior exposure to non-pathogenic calicivirus RCV-A1 reduces both infection rate and mortality from rabbit haemorrhagic disease in a population of wild rabbits in Australia. / Cooke, B. D.; Duncan, R. P.; Mcdonald, I.; Liu, J.; Capucci, L.; Mutze, G. J.; Strive, T.

    In: Transboundary and Emerging Diseases, Vol. 65, No. 2, 04.2018, p. 470-477.

    Research output: Contribution to journalArticle

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    T1 - Prior exposure to non-pathogenic calicivirus RCV-A1 reduces both infection rate and mortality from rabbit haemorrhagic disease in a population of wild rabbits in Australia

    AU - Cooke, B. D.

    AU - Duncan, R. P.

    AU - Mcdonald, I.

    AU - Liu, J.

    AU - Capucci, L.

    AU - Mutze, G. J.

    AU - Strive, T.

    PY - 2018/4

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    AB - Mortality caused by rabbit haemorrhagic disease virus (RHDV) in wild rabbits is reduced in parts of Australia where the related, non-pathogenic calicivirus RCV-A1 is endemic. Laboratory experiments previously showed that prior infection with RCV-A1 enabled rabbits to better withstand subsequent infection with highly virulent RHDV, and this was assumed to explain higher survival. Here, we analyse serological data from the field suggesting that reduced mortality rates among wild rabbits may also result from rabbits previously infected with RCV-A1 having a reduced likelihood of RHDV infection. We discuss the possible mechanisms underlying this finding and its implications. The methods we describe for analysing field data gave far greater insights into epidemiological processes and virus interactions than gained from reporting basic seroprevalence rates alone.

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    KW - Non-pathogenic

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