@article{a7a8486bd40948d5b18bed8114379f91,
title = "Prior exposure to non-pathogenic calicivirus RCV-A1 reduces both infection rate and mortality from rabbit haemorrhagic disease in a population of wild rabbits in Australia",
abstract = "Mortality caused by rabbit haemorrhagic disease virus (RHDV) in wild rabbits is reduced in parts of Australia where the related, non-pathogenic calicivirus RCV-A1 is endemic. Laboratory experiments previously showed that prior infection with RCV-A1 enabled rabbits to better withstand subsequent infection with highly virulent RHDV, and this was assumed to explain higher survival. Here, we analyse serological data from the field suggesting that reduced mortality rates among wild rabbits may also result from rabbits previously infected with RCV-A1 having a reduced likelihood of RHDV infection. We discuss the possible mechanisms underlying this finding and its implications. The methods we describe for analysing field data gave far greater insights into epidemiological processes and virus interactions than gained from reporting basic seroprevalence rates alone.",
keywords = "Bayesian model, Non-pathogenic, Oryctolagus, RHDV, Serology, serology, non-pathogenic",
author = "Cooke, {B. D.} and Duncan, {R. P.} and I. Mcdonald and J. Liu and L. Capucci and Mutze, {G. J.} and T. Strive",
note = "Funding Information: Our thanks to N. Amos, R. Wallis, J. Wright and R. Moore for help in collecting field samples and data. J. Merchant and N. Sims carried out initial RHDV ELISA testing, dried and weighed eye lenses and maintained serological data bases. Initial sampling and RHD antibody analysis were financially supported by the Australian and New Zealand Rabbit Calicivirus Disease Program, and RCV-A1 antibody analysis was supported by Invasive Animals Cooperative Research Centre (7.T.1 Enhancing RHDV Effectiveness). We thank the Istituto Zooprofilattico Sperimentale della Lombardia e dell{\textquoteright}Emilia Romagna, Brescia, Italy, for supplying RHDV ELISA reagents. Funding Information: Our thanks to N. Amos, R. Wallis, J. Wright and R. Moore for help in collecting field samples and data. J. Merchant and N. Sims carried out initial RHDV ELISA testing, dried and weighed eye lenses and maintained serological data bases. Initial sampling and RHD antibody analysis were financially supported by the Australian and New Zealand Rabbit Calicivirus Disease Program, and RCV-A1 antibody analysis was supported by Invasive Animals Cooperative Research Centre (7.T.1 Enhancing RHDV Effectiveness). We thank the Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna, Brescia, Italy, for supplying RHDV ELISA reagents. Publisher Copyright: {\textcopyright} 2017 Blackwell Verlag GmbH",
year = "2018",
month = apr,
doi = "10.1111/tbed.12786",
language = "English",
volume = "65",
pages = "470--477",
journal = "Transboundary and Emerging Diseases",
issn = "1865-1674",
publisher = "Wiley-Blackwell",
number = "2",
}