Probenecid inhibits SARS-CoV-2 replication in vivo and in vitro

Jackelyn Murray; Robert J. Hogan; David E. Martin; Kathy Blahunka; Fred D. Sancilio; Rajiv Balyan; Mark Lovern; Richard Still; Ralph A. Tripp

doi:10.1038/s41598-021-97658-w

Probenecid inhibits SARS-CoV-2 replication in vivo and in vitro

Jackelyn Murray, Robert J. Hogan, David E. Martin, Kathy Blahunka, Fred D. Sancilio, Rajiv Balyan, Mark Lovern, Richard Still, Ralph A. Tripp

Research output: Contribution to journal › Article › peer-review

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Abstract

Effective vaccines are slowing the COVID-19 pandemic, but SARS-CoV-2 will likely remain an issue in the future making it important to have therapeutics to treat patients. There are few options for treating patients with COVID-19. We show probenecid potently blocks SARS-CoV-2 replication in mammalian cells and virus replication in a hamster model. Furthermore, we demonstrate that plasma concentrations up to 50-fold higher than the protein binding adjusted IC₉₀ value are achievable for 24 h following a single oral dose. These data support the potential clinical utility of probenecid to control SARS-CoV-2 infection in humans.

Original language	English
Article number	18085
Pages (from-to)	1-7
Number of pages	7
Journal	Scientific Reports
Volume	11
Issue number	1
DOIs	https://doi.org/10.1038/s41598-021-97658-w
Publication status	Published - Dec 2021
Externally published	Yes

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ArticleFinal published version, 1.42 MBLicence: CC BY

Cite this

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AU - Martin, David E.

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AU - Balyan, Rajiv

AU - Lovern, Mark

AU - Still, Richard

AU - Tripp, Ralph A.

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Probenecid inhibits SARS-CoV-2 replication in vivo and in vitro

Abstract

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