Probiotic supplementation for respiratory and gastrointestinal illness symptoms in healthy physically active individuals

Nicholas West, Peggy L. Horn, David Pyne, Val Gebski, Sampo Lahtinen

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Background aims: To examine the effect of supplementation with probiotics on respiratory and gastrointestinal illness in healthy active men and women. Methods: A randomised double-blind placebo-controlled trial was conducted. Four hundred and sixty five participants (241 males; age 35±12y (mean±SD) and 224 females; age 36±12y) were assigned to one of three groups: Group 1 - Bifidobacterium animalis subsp. lactis Bl-04 (Bl-04) 2.0×109colony forming units per day, CFU per day, Group 2 - Lactobacillus acidophilus NCFM and Bifidobacterium animalis subsp. lactis Bi-07 (NCFM Bi-07) 5×109CFU each per day) or Group 3 - placebo mixed in a drink. Results: The risk of an upper respiratory illness episode was significantly lower in the Bl-04 group (hazard ratio 0.73; 95% confidence interval 0.55-0.95; P=0.022) compared to placebo. There was no significant difference in illness risk between the NCFM Bi-07 group (hazard ratio 0.81; 0.62-1.08; P=0.15) and the placebo group. There was a 0.7 and 0.9 month delay in the median time to an illness episode in the Bl-04 and NCFM Bi-07 groups respectively compared to placebo (placebo 2.5 months; Bl-04 3.2 months; NCFM Bi-07 3.4 months). There were insufficient GI illness episodes for analysis. The NCFM Bi-07 group but not the Bl-04 group undertook significantly more physical activity (8.5%; 6.7%-10%; P
Original languageEnglish
Pages (from-to)581-587
Number of pages7
JournalClinical Nutrition
Volume33
Issue number4
DOIs
Publication statusPublished - 2014
Externally publishedYes

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Probiotics
Placebos
Lactobacillus acidophilus
Confidence Intervals
Exercise

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West, Nicholas ; Horn, Peggy L. ; Pyne, David ; Gebski, Val ; Lahtinen, Sampo. / Probiotic supplementation for respiratory and gastrointestinal illness symptoms in healthy physically active individuals. In: Clinical Nutrition. 2014 ; Vol. 33, No. 4. pp. 581-587.
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Probiotic supplementation for respiratory and gastrointestinal illness symptoms in healthy physically active individuals. / West, Nicholas; Horn, Peggy L.; Pyne, David; Gebski, Val; Lahtinen, Sampo.

In: Clinical Nutrition, Vol. 33, No. 4, 2014, p. 581-587.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Probiotic supplementation for respiratory and gastrointestinal illness symptoms in healthy physically active individuals

AU - West, Nicholas

AU - Horn, Peggy L.

AU - Pyne, David

AU - Gebski, Val

AU - Lahtinen, Sampo

PY - 2014

Y1 - 2014

N2 - Background aims: To examine the effect of supplementation with probiotics on respiratory and gastrointestinal illness in healthy active men and women. Methods: A randomised double-blind placebo-controlled trial was conducted. Four hundred and sixty five participants (241 males; age 35±12y (mean±SD) and 224 females; age 36±12y) were assigned to one of three groups: Group 1 - Bifidobacterium animalis subsp. lactis Bl-04 (Bl-04) 2.0×109colony forming units per day, CFU per day, Group 2 - Lactobacillus acidophilus NCFM and Bifidobacterium animalis subsp. lactis Bi-07 (NCFM Bi-07) 5×109CFU each per day) or Group 3 - placebo mixed in a drink. Results: The risk of an upper respiratory illness episode was significantly lower in the Bl-04 group (hazard ratio 0.73; 95% confidence interval 0.55-0.95; P=0.022) compared to placebo. There was no significant difference in illness risk between the NCFM Bi-07 group (hazard ratio 0.81; 0.62-1.08; P=0.15) and the placebo group. There was a 0.7 and 0.9 month delay in the median time to an illness episode in the Bl-04 and NCFM Bi-07 groups respectively compared to placebo (placebo 2.5 months; Bl-04 3.2 months; NCFM Bi-07 3.4 months). There were insufficient GI illness episodes for analysis. The NCFM Bi-07 group but not the Bl-04 group undertook significantly more physical activity (8.5%; 6.7%-10%; P

AB - Background aims: To examine the effect of supplementation with probiotics on respiratory and gastrointestinal illness in healthy active men and women. Methods: A randomised double-blind placebo-controlled trial was conducted. Four hundred and sixty five participants (241 males; age 35±12y (mean±SD) and 224 females; age 36±12y) were assigned to one of three groups: Group 1 - Bifidobacterium animalis subsp. lactis Bl-04 (Bl-04) 2.0×109colony forming units per day, CFU per day, Group 2 - Lactobacillus acidophilus NCFM and Bifidobacterium animalis subsp. lactis Bi-07 (NCFM Bi-07) 5×109CFU each per day) or Group 3 - placebo mixed in a drink. Results: The risk of an upper respiratory illness episode was significantly lower in the Bl-04 group (hazard ratio 0.73; 95% confidence interval 0.55-0.95; P=0.022) compared to placebo. There was no significant difference in illness risk between the NCFM Bi-07 group (hazard ratio 0.81; 0.62-1.08; P=0.15) and the placebo group. There was a 0.7 and 0.9 month delay in the median time to an illness episode in the Bl-04 and NCFM Bi-07 groups respectively compared to placebo (placebo 2.5 months; Bl-04 3.2 months; NCFM Bi-07 3.4 months). There were insufficient GI illness episodes for analysis. The NCFM Bi-07 group but not the Bl-04 group undertook significantly more physical activity (8.5%; 6.7%-10%; P

KW - Bifidobacterium animalis Subsp. lactis Bi-07

KW - Bifidobacterium animalis Subsp. lactis Bl-04

KW - Healthy adults

KW - Lactobacillus acidophilus NCFM

KW - Probiotics

KW - Respiratory illness

U2 - 10.1016/j.clnu.2013.10.002

DO - 10.1016/j.clnu.2013.10.002

M3 - Article

VL - 33

SP - 581

EP - 587

JO - Clinical Nutrition

JF - Clinical Nutrition

SN - 0261-5614

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ER -