Protein tyrosine phosphatase 1B (PTP1B) inhibitors from Morinda citrifolia (Noni) and their insulin mimetic activity

Phi-Hung Nguyen, Jun-Li Yang, Mohammad N Uddin, So-Lim Park, Seong-Il Lim, Da-Woon Jung, Darren R Williams, Won-Keun Oh

Research output: Contribution to journalArticlepeer-review

62 Citations (Scopus)

Abstract

As part of our ongoing search for new antidiabetic agents from medicinal plants, we found that a methanol extract of Morinda citrifolia showed potential stimulatory effects on glucose uptake in 3T3-L1 adipocyte cells. Bioassay-guided fractionation of this active extract yielded two new lignans (1 and 2) and three new neolignans (9, 10, and 14), as well as 10 known compounds (3-8, 11-13, and 15). The absolute configurations of compounds 9, 10, and 14 were determined by ECD spectra analysis. Compounds 3, 6, 7, and 15 showed inhibitory effects on PTP1B enzyme with IC50 values of 21.86 ± 0.48, 15.01 ± 0.20, 16.82 ± 0.42, and 4.12 ± 0.09 μM, respectively. Furthermore, compounds 3, 6, 7, and 15 showed strong stimulatory effects on 2-NBDG uptake in 3T3-L1 adipocyte cells. This study indicated the potential of compounds 3, 6, 7, and 15 as lead molecules for antidiabetic agents.

Original languageEnglish
Pages (from-to)2080-2087
Number of pages8
JournalJournal of Natural Products
Volume76
Issue number11
DOIs
Publication statusPublished - 22 Nov 2013
Externally publishedYes

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