Proteolytic degradation of heat shock protein A2 occurs in response to oxidative stress in male germ cells of the mouse

Keyphrases

• Oxidative Stress 100%
• Male Germ Cells 100%
• Proteolytic Degradation 100%
• Heat Shock Protein A2 100%
• 4-hydroxynonenal (4-HNE) 68%
• GC-2 Cells 31%
• Germ Cells 15%
• Spermatozoa 15%
• Lipid Aldehydes 15%
• A2 Protein 15%
• Ubiquitination 15%
• Bcl2-associated Athanogene 3 (BAG3) 15%
• Protein Expression 10%
• Testicle 10%
• Adduction 10%
• Post-translational Modification 10%
• Hydrogen Peroxide 10%
• Pachytene Spermatocytes 10%
• Mouse Testis 10%
• Lysate 10%
• Co-chaperone 10%
• Mouse Model 5%
• Dose Effect 5%
• Setting Method 5%
• Statistical Significance 5%
• Infertility 5%
• Clinical Setting 5%
• Biological Basis 5%
• Treatment Regime 5%
• Antioxidant 5%
• Protein Level 5%
• Dissociation 5%
• Zona Pellucida 5%
• Degradation Pathway 5%
• Infertile Women 5%
• Co-immunoprecipitation (co-IP) 5%
• Immunoblotting 5%
• Infertile Male 5%
• Proteasome Activity 5%
• Round Spermatid 5%
• Proximity Ligation Assay 5%
• Normozoospermic 5%
• Causative Link 5%
• Human Sperm 5%
• Pharmacological Inhibitors 5%
• Biological Replicates 5%
• Immunocytochemistry 5%
• Cellular Oxidative Stress 5%
• Protein Stability 5%
• Sperma 5%
• MG132 5%
• Human Germ Cells 5%
• Male Mouse Germ Cells 5%
• Ubiquitin-proteasome System 5%
• Failed Fertilization 5%
• Egg Recognition 5%
• Primary Culture 5%
• Proteasomal Degradation 5%
• Sperm-egg Interaction 5%
• Toxic Lipids 5%
• Lysosomal Degradation 5%
• Infertile Patients 5%

Biochemistry, Genetics and Molecular Biology

• Oxidative Stress 100%
• Germ Cell 100%
• Heat Shock Protein 100%
• Lipid 15%
• Proteasome 15%
• Ubiquitination 15%
• Protein Expression 10%
• Posttranslational Modification 10%
• Adduction 10%
• Pachytene 10%
• Cell Lysate 10%
• Co-Chaperone 10%
• Mouse Model 5%
• Mediator 5%
• Statistical Test 5%
• Immunoprecipitation 5%
• Hydrogen Peroxide 5%
• Immunoblotting 5%
• Spermatid 5%
• LARGE 5%
• Zona Pellucida 5%
• Immunocytochemistry 5%
• MG132 5%
• Primary Culture 5%
• Ubiquitin 5%
• Protein Stability 5%
• Deficiency 5%

Pharmacology, Toxicology and Pharmaceutical Science

• Heat Shock Protein 100%
• 4 Hydroxynonenal 68%
• Aldehyde 15%
• Proteasome 15%
• Chaperone 10%
• Mouse Model 5%
• Antioxidant 5%
• Western Blot 5%
• Immunoprecipitation 5%
• Hydrogen Peroxide 5%
• Benzyloxycarbonylleucylleucylleucinal 5%
• Ubiquitin 5%
• Primary Culture 5%