TY - JOUR
T1 - Protocol for spatial prediction of soil transmitted helminth prevalence in the Western Pacific region using a meta-analytical approach
AU - Gilmour, Beth
AU - Wangdi, Kingley
AU - Restrepo, Angela Cadavid
AU - Tsheten, Tsheten
AU - Kelly, Matthew
AU - Clements, Archie
AU - Gray, Darren
AU - Lau, Colleen
AU - Espino, Fe Esperanza
AU - Daga, Chona
AU - Mapalo, Vanessa
AU - Vaz Nery, Susana
AU - Bartlett, Adam
AU - Gebreyohannes, Eyob Alemayehu
AU - Alene, Kefyalew Addis
N1 - © 2024. The Author(s).
Funding Information:
This project is funded by the National Health and Medical Research Council (NHMRC). NHMRC ref # APP1153727.
Publisher Copyright:
© The Author(s) 2024.
PY - 2024/2/6
Y1 - 2024/2/6
N2 - BACKGROUND: Soil transmitted helminth (STH) infections are estimated to impact 24% of the world's population and are responsible for chronic and debilitating morbidity. Disadvantaged communities are among the worst affected and are further marginalized as infection prevalence fuels the poverty cycle. Ambitious targets have been set to eliminate STH infections, but accurate epidemiological data will be required to inform appropriate interventions. This paper details the protocol for an analysis that aims to produce spatial prediction mapping of STH prevalence in the Western Pacific Region (WPR).METHODS: The protocol follows the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocol (PRISMA-P) guidelines. The study design will combine the principles of systematic review, meta-analysis, and geospatial analysis. Systematic searches will be undertaken in PubMed, Scopus, ProQuest, Embase, and Web of Science for studies undertaken post 2000, to identify surveys that enable the prevalence of human STH infection within the WPR to be calculated. Covariate data for multivariable analysis will be obtained from publicly accessible sources. Survey data will be geolocated, and STH prevalence and covariates will be linked to produce a spatially referenced dataset for analysis. Bayesian model-based geostatistics will be used to generate spatially continuous estimates of STH prevalence mapped to a resolution of 1 km2. A separate geospatial model will be constructed for each STH species. Predictions of prevalence will be made for unsampled locations and maps will be overlaid for each STH species to obtain co-endemicity maps.DISCUSSION: This protocol facilitates study replication and may be applied to other infectious diseases or alternate geographies. Results of the subsequent analysis will identify geographies with high STH prevalence's and can be used to inform resource allocation in combating this neglected tropical disease.TRIAL REGISTRATION: Open Science Framework: osf.io/qmxcj.
AB - BACKGROUND: Soil transmitted helminth (STH) infections are estimated to impact 24% of the world's population and are responsible for chronic and debilitating morbidity. Disadvantaged communities are among the worst affected and are further marginalized as infection prevalence fuels the poverty cycle. Ambitious targets have been set to eliminate STH infections, but accurate epidemiological data will be required to inform appropriate interventions. This paper details the protocol for an analysis that aims to produce spatial prediction mapping of STH prevalence in the Western Pacific Region (WPR).METHODS: The protocol follows the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocol (PRISMA-P) guidelines. The study design will combine the principles of systematic review, meta-analysis, and geospatial analysis. Systematic searches will be undertaken in PubMed, Scopus, ProQuest, Embase, and Web of Science for studies undertaken post 2000, to identify surveys that enable the prevalence of human STH infection within the WPR to be calculated. Covariate data for multivariable analysis will be obtained from publicly accessible sources. Survey data will be geolocated, and STH prevalence and covariates will be linked to produce a spatially referenced dataset for analysis. Bayesian model-based geostatistics will be used to generate spatially continuous estimates of STH prevalence mapped to a resolution of 1 km2. A separate geospatial model will be constructed for each STH species. Predictions of prevalence will be made for unsampled locations and maps will be overlaid for each STH species to obtain co-endemicity maps.DISCUSSION: This protocol facilitates study replication and may be applied to other infectious diseases or alternate geographies. Results of the subsequent analysis will identify geographies with high STH prevalence's and can be used to inform resource allocation in combating this neglected tropical disease.TRIAL REGISTRATION: Open Science Framework: osf.io/qmxcj.
KW - Animals
KW - Humans
KW - Bayes Theorem
KW - Helminthiasis/epidemiology
KW - Helminths
KW - Meta-Analysis as Topic
KW - Prevalence
KW - Soil/parasitology
KW - Systematic Reviews as Topic
KW - STH
KW - Soil transmitted helminth
KW - Spatial prediction mapping
KW - Western Pacific
UR - http://www.scopus.com/inward/record.url?scp=85184561699&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/record.url?scp=85185686691&partnerID=8YFLogxK
UR - https://systematicreviewsjournal.biomedcentral.com/articles/10.1186/s13643-024-02495-3
U2 - 10.1186/s13643-024-02469-5
DO - 10.1186/s13643-024-02469-5
M3 - Article
C2 - 38321560
SN - 2046-4053
VL - 13
SP - 1
EP - 6
JO - Systematic Reviews
JF - Systematic Reviews
IS - 1
M1 - 55
ER -
