Pseudo-CT generation for mri-only radiotherapy: Comparative study between a generative adversarial network, a u-net network, a patch-based, and an atlas based methods

Axel Largent, Jean Claude Nunes, Herve Saint-Jalmes, John Baxter, Peter Greer, Jason Dowling, Renaud De Crevoisier, Oscar Acosta

Research output: A Conference proceeding or a Chapter in BookConference contributionpeer-review

2 Citations (Scopus)

Abstract

As new radiotherapy treatment systems using MRI (rather than traditional CT) are being developed, the accurate calculation of dose maps from MR imaging has become an increasing concern. MRI provides good soft-tissue but, unlike CT, lacks the electron density information necessary for dose calculation. In this paper, we proposed a generative adversarial network (GAN) using a perceptual loss to generate pseudo-CTs for prostate MRI dose calculation. This network was evaluated and compared to a U-Net network, a patch-based (PBM) and an atlas-based methods (ABM). Influence of the perceptual loss was assessed by comparing this network to a GAN using a L2 loss. GANs and U-Nets are rather similar with slightly better results for GANs. The proposed GAN outperformed the PBM by 9% and the ABM by 13% in term of MAE in whole pelvis. This method could be used for online dose calculation in MRI-only radiotherapy.

Original languageEnglish
Title of host publicationISBI 2019 - 2019 IEEE International Symposium on Biomedical Imaging
PublisherIEEE, Institute of Electrical and Electronics Engineers
Pages1109-1113
Number of pages5
ISBN (Electronic)9781538636411
DOIs
Publication statusPublished - Apr 2019
Externally publishedYes
Event16th IEEE International Symposium on Biomedical Imaging, ISBI 2019 - Venice, Italy
Duration: 8 Apr 201911 Apr 2019

Publication series

NameProceedings - International Symposium on Biomedical Imaging
Volume2019-April
ISSN (Print)1945-7928
ISSN (Electronic)1945-8452

Conference

Conference16th IEEE International Symposium on Biomedical Imaging, ISBI 2019
Country/TerritoryItaly
CityVenice
Period8/04/1911/04/19

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