Rabbit Haemorrhagic Disease: Applying Occam's Razor to competing hypotheses

David Peacock, Greg Mutze, Ron Sinclair, John Kovaliski, Brian Cooke

    Research output: Contribution to journalEditorial

    3 Citations (Scopus)

    Abstract

    Rabbit haemorrhagic disease virus (RHDV) is a highly virulent lagovirus endemic in Europe and Australasian populations of the European rabbit, Oryctolagus cuniculus. It has also caused several unexplained disease outbreaks in domestic European rabbits in North America. Nonpathogenic spread of RHDV leading to persistent infection which later reactivated has recently been proposed as the cause of overt disease and death of a pet rabbit in Canada, the first confirmed case of Rabbit haemorrhagic disease in that country. We suggest that there is little evidence to support non-pathogenic spread of virulent RHDV, some evidence that is contradictory, and evidence to support a simpler alternative hypothesis. RHDV can be spread over long distances between sparse rabbit populations by fomites or flying insects. Although highly pathogenic, RHDV can be limited in its spread within rabbit populations, or its presence masked by closely related but non-pathogenic lagoviruses which can provide protection against acute disease. In the absence of any evidence from clinical studies to support reactivation of persistent RHDV infection, the simpler explanation seems more likely to be correct.
    Original languageEnglish
    Pages (from-to)1038-1041
    Number of pages4
    JournalMolecular Ecology
    Volume21
    Issue number5
    DOIs
    Publication statusPublished - 2012

    Fingerprint

    Rabbit hemorrhagic disease virus
    Rabbit Haemorrhagic Disease Virus
    rabbits
    Rabbits
    Lagovirus
    virus
    fomites
    Fomites
    acute course
    Population
    Oryctolagus cuniculus
    Pets
    infection
    pets
    Acute Disease
    Virus Diseases
    North America
    clinical trials
    flight
    Canada

    Cite this

    Peacock, D., Mutze, G., Sinclair, R., Kovaliski, J., & Cooke, B. (2012). Rabbit Haemorrhagic Disease: Applying Occam's Razor to competing hypotheses. Molecular Ecology, 21(5), 1038-1041. https://doi.org/10.1111/j.1365-294X.2011.05466.x
    Peacock, David ; Mutze, Greg ; Sinclair, Ron ; Kovaliski, John ; Cooke, Brian. / Rabbit Haemorrhagic Disease: Applying Occam's Razor to competing hypotheses. In: Molecular Ecology. 2012 ; Vol. 21, No. 5. pp. 1038-1041.
    @article{00c2d80f2af14bfeb4a39a9f51a71b30,
    title = "Rabbit Haemorrhagic Disease: Applying Occam's Razor to competing hypotheses",
    abstract = "Rabbit haemorrhagic disease virus (RHDV) is a highly virulent lagovirus endemic in Europe and Australasian populations of the European rabbit, Oryctolagus cuniculus. It has also caused several unexplained disease outbreaks in domestic European rabbits in North America. Nonpathogenic spread of RHDV leading to persistent infection which later reactivated has recently been proposed as the cause of overt disease and death of a pet rabbit in Canada, the first confirmed case of Rabbit haemorrhagic disease in that country. We suggest that there is little evidence to support non-pathogenic spread of virulent RHDV, some evidence that is contradictory, and evidence to support a simpler alternative hypothesis. RHDV can be spread over long distances between sparse rabbit populations by fomites or flying insects. Although highly pathogenic, RHDV can be limited in its spread within rabbit populations, or its presence masked by closely related but non-pathogenic lagoviruses which can provide protection against acute disease. In the absence of any evidence from clinical studies to support reactivation of persistent RHDV infection, the simpler explanation seems more likely to be correct.",
    keywords = "Oryctolagus cuniculus, pathogenicity, RHD, rabbit.",
    author = "David Peacock and Greg Mutze and Ron Sinclair and John Kovaliski and Brian Cooke",
    year = "2012",
    doi = "10.1111/j.1365-294X.2011.05466.x",
    language = "English",
    volume = "21",
    pages = "1038--1041",
    journal = "Molecular Biology",
    issn = "0962-1083",
    publisher = "Wiley-Blackwell",
    number = "5",

    }

    Peacock, D, Mutze, G, Sinclair, R, Kovaliski, J & Cooke, B 2012, 'Rabbit Haemorrhagic Disease: Applying Occam's Razor to competing hypotheses', Molecular Ecology, vol. 21, no. 5, pp. 1038-1041. https://doi.org/10.1111/j.1365-294X.2011.05466.x

    Rabbit Haemorrhagic Disease: Applying Occam's Razor to competing hypotheses. / Peacock, David; Mutze, Greg; Sinclair, Ron; Kovaliski, John; Cooke, Brian.

    In: Molecular Ecology, Vol. 21, No. 5, 2012, p. 1038-1041.

    Research output: Contribution to journalEditorial

    TY - JOUR

    T1 - Rabbit Haemorrhagic Disease: Applying Occam's Razor to competing hypotheses

    AU - Peacock, David

    AU - Mutze, Greg

    AU - Sinclair, Ron

    AU - Kovaliski, John

    AU - Cooke, Brian

    PY - 2012

    Y1 - 2012

    N2 - Rabbit haemorrhagic disease virus (RHDV) is a highly virulent lagovirus endemic in Europe and Australasian populations of the European rabbit, Oryctolagus cuniculus. It has also caused several unexplained disease outbreaks in domestic European rabbits in North America. Nonpathogenic spread of RHDV leading to persistent infection which later reactivated has recently been proposed as the cause of overt disease and death of a pet rabbit in Canada, the first confirmed case of Rabbit haemorrhagic disease in that country. We suggest that there is little evidence to support non-pathogenic spread of virulent RHDV, some evidence that is contradictory, and evidence to support a simpler alternative hypothesis. RHDV can be spread over long distances between sparse rabbit populations by fomites or flying insects. Although highly pathogenic, RHDV can be limited in its spread within rabbit populations, or its presence masked by closely related but non-pathogenic lagoviruses which can provide protection against acute disease. In the absence of any evidence from clinical studies to support reactivation of persistent RHDV infection, the simpler explanation seems more likely to be correct.

    AB - Rabbit haemorrhagic disease virus (RHDV) is a highly virulent lagovirus endemic in Europe and Australasian populations of the European rabbit, Oryctolagus cuniculus. It has also caused several unexplained disease outbreaks in domestic European rabbits in North America. Nonpathogenic spread of RHDV leading to persistent infection which later reactivated has recently been proposed as the cause of overt disease and death of a pet rabbit in Canada, the first confirmed case of Rabbit haemorrhagic disease in that country. We suggest that there is little evidence to support non-pathogenic spread of virulent RHDV, some evidence that is contradictory, and evidence to support a simpler alternative hypothesis. RHDV can be spread over long distances between sparse rabbit populations by fomites or flying insects. Although highly pathogenic, RHDV can be limited in its spread within rabbit populations, or its presence masked by closely related but non-pathogenic lagoviruses which can provide protection against acute disease. In the absence of any evidence from clinical studies to support reactivation of persistent RHDV infection, the simpler explanation seems more likely to be correct.

    KW - Oryctolagus cuniculus

    KW - pathogenicity

    KW - RHD

    KW - rabbit.

    U2 - 10.1111/j.1365-294X.2011.05466.x

    DO - 10.1111/j.1365-294X.2011.05466.x

    M3 - Editorial

    VL - 21

    SP - 1038

    EP - 1041

    JO - Molecular Biology

    JF - Molecular Biology

    SN - 0962-1083

    IS - 5

    ER -