Radionuclide therapy

Janelle M. Wheat, Geoffrey M. Currie, Rob DAVIDSON, H Kiat

Research output: Contribution to journalReview article

Abstract

This article follows the article An Introduction to Nuclear Medicine published in this issue of The Radiographer. Nuclear medicine is the injection, ingestion or inhalation of a radiopharmaceutical for the purpose of diagnosis or therapy. While the previous article focused on the fundamental principles of diagnostic imaging, this paper focuses on the role of nuclear medicine in the treatment of disease. Radionuclide therapy differs from other forms of ionising radiation therapies, such as external beam radiation therapy and brachytherapy, in that photons are not the prime means damaging the target volume. Rather beta and sometimes alpha particles are used to deliver the dose to the target. Delivery methods and biodistribution of the radionuclides are important considerations for optimising the dose to the target volume and for minimising the radiation burden to non‐target tissues. One of the benefits associated with some radionuclides used in therapy is that imaging can occur at the concurrently if the radiopharmaceuticals emits both a particle and a photon. This article provides an overview of the mechanisms of dose delivery, types of radionuclides that are used in therapy, clinical applications, recent advances and the future of radionuclides therapies. An understanding of the technical and clinical aspects of radionuclide therapies can provide an improved understanding for medical radiation scientists and in doing so benefit the patient.
Original languageEnglish
Pages (from-to)53-59
Number of pages7
JournalThe Radiographer
Volume58
Issue number3
DOIs
Publication statusPublished - 2011
Externally publishedYes

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Radioisotopes
Nuclear Medicine
Radiopharmaceuticals
Photons
Therapeutics
Radiotherapy
Alpha Particles
Radiation
Brachytherapy
Diagnostic Imaging
Ionizing Radiation
Inhalation
Eating
Injections

Cite this

Wheat, Janelle M. ; Currie, Geoffrey M. ; DAVIDSON, Rob ; Kiat, H. / Radionuclide therapy. In: The Radiographer. 2011 ; Vol. 58, No. 3. pp. 53-59.
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title = "Radionuclide therapy",
abstract = "This article follows the article An Introduction to Nuclear Medicine published in this issue of The Radiographer. Nuclear medicine is the injection, ingestion or inhalation of a radiopharmaceutical for the purpose of diagnosis or therapy. While the previous article focused on the fundamental principles of diagnostic imaging, this paper focuses on the role of nuclear medicine in the treatment of disease. Radionuclide therapy differs from other forms of ionising radiation therapies, such as external beam radiation therapy and brachytherapy, in that photons are not the prime means damaging the target volume. Rather beta and sometimes alpha particles are used to deliver the dose to the target. Delivery methods and biodistribution of the radionuclides are important considerations for optimising the dose to the target volume and for minimising the radiation burden to non‐target tissues. One of the benefits associated with some radionuclides used in therapy is that imaging can occur at the concurrently if the radiopharmaceuticals emits both a particle and a photon. This article provides an overview of the mechanisms of dose delivery, types of radionuclides that are used in therapy, clinical applications, recent advances and the future of radionuclides therapies. An understanding of the technical and clinical aspects of radionuclide therapies can provide an improved understanding for medical radiation scientists and in doing so benefit the patient.",
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language = "English",
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Wheat, JM, Currie, GM, DAVIDSON, R & Kiat, H 2011, 'Radionuclide therapy', The Radiographer, vol. 58, no. 3, pp. 53-59. https://doi.org/10.1002/j.2051-3909.2011.tb00156.x

Radionuclide therapy. / Wheat, Janelle M.; Currie, Geoffrey M.; DAVIDSON, Rob; Kiat, H.

In: The Radiographer, Vol. 58, No. 3, 2011, p. 53-59.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Radionuclide therapy

AU - Wheat, Janelle M.

AU - Currie, Geoffrey M.

AU - DAVIDSON, Rob

AU - Kiat, H

PY - 2011

Y1 - 2011

N2 - This article follows the article An Introduction to Nuclear Medicine published in this issue of The Radiographer. Nuclear medicine is the injection, ingestion or inhalation of a radiopharmaceutical for the purpose of diagnosis or therapy. While the previous article focused on the fundamental principles of diagnostic imaging, this paper focuses on the role of nuclear medicine in the treatment of disease. Radionuclide therapy differs from other forms of ionising radiation therapies, such as external beam radiation therapy and brachytherapy, in that photons are not the prime means damaging the target volume. Rather beta and sometimes alpha particles are used to deliver the dose to the target. Delivery methods and biodistribution of the radionuclides are important considerations for optimising the dose to the target volume and for minimising the radiation burden to non‐target tissues. One of the benefits associated with some radionuclides used in therapy is that imaging can occur at the concurrently if the radiopharmaceuticals emits both a particle and a photon. This article provides an overview of the mechanisms of dose delivery, types of radionuclides that are used in therapy, clinical applications, recent advances and the future of radionuclides therapies. An understanding of the technical and clinical aspects of radionuclide therapies can provide an improved understanding for medical radiation scientists and in doing so benefit the patient.

AB - This article follows the article An Introduction to Nuclear Medicine published in this issue of The Radiographer. Nuclear medicine is the injection, ingestion or inhalation of a radiopharmaceutical for the purpose of diagnosis or therapy. While the previous article focused on the fundamental principles of diagnostic imaging, this paper focuses on the role of nuclear medicine in the treatment of disease. Radionuclide therapy differs from other forms of ionising radiation therapies, such as external beam radiation therapy and brachytherapy, in that photons are not the prime means damaging the target volume. Rather beta and sometimes alpha particles are used to deliver the dose to the target. Delivery methods and biodistribution of the radionuclides are important considerations for optimising the dose to the target volume and for minimising the radiation burden to non‐target tissues. One of the benefits associated with some radionuclides used in therapy is that imaging can occur at the concurrently if the radiopharmaceuticals emits both a particle and a photon. This article provides an overview of the mechanisms of dose delivery, types of radionuclides that are used in therapy, clinical applications, recent advances and the future of radionuclides therapies. An understanding of the technical and clinical aspects of radionuclide therapies can provide an improved understanding for medical radiation scientists and in doing so benefit the patient.

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DO - 10.1002/j.2051-3909.2011.tb00156.x

M3 - Review article

VL - 58

SP - 53

EP - 59

JO - The Radiographer

JF - The Radiographer

SN - 1170-9758

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