Recent assembly of an imprinted domain from non-imprinted components

R.W. Rapkins, T. Hore, M. Smithwick, E. Ager, A.J. Pask, M.B. Renfree, M. Kohn, H. Hameister, R.D. Nicholls, J.E. Deakin, J.A. Marshall Graves

    Research output: Contribution to journalArticle

    61 Citations (Scopus)

    Abstract

    Genomic imprinting, representing parent-specific expression of alleles at a locus, raises many questions about how - and especially why - epigenetic silencing of mammalian genes evolved. We present the first in-depth study of how a human imprinted domain evolved, analyzing a domain containing several imprinted genes that are involved in human disease. Using comparisons of orthologous genes in humans, marsupials, and the platypus, we discovered that the Prader-Willi/Angelman syndrome region on human Chromosome 15q was assembled only recently (105-180 million years ago). This imprinted domain arose after a region bearing UBE3A (Angelman syndrome) fused with an unlinked region bearing SNRPN (Prader-Willi syndrome), which had duplicated from the non-imprinted SNRPB/B′. This region independently acquired several retroposed gene copies and arrays of small nucleolar RNAs from different parts of the genome. In their original configurations, SNRPN and UBE3A are expressed from both alleles, implying that acquisition of imprinting occurred after their rearrangement and required the evolution of a control locus. Thus, the evolution of imprinting in viviparous mammals is ongoing.
    Original languageUndefined
    Pages (from-to)1666-1675
    Number of pages10
    JournalPLoS Genetics
    Volume2
    Issue number10
    DOIs
    Publication statusPublished - 2006

    Cite this

    Rapkins, R. W., Hore, T., Smithwick, M., Ager, E., Pask, A. J., Renfree, M. B., ... Marshall Graves, J. A. (2006). Recent assembly of an imprinted domain from non-imprinted components. PLoS Genetics, 2(10), 1666-1675. https://doi.org/10.1371/journal.pgen.0020182
    Rapkins, R.W. ; Hore, T. ; Smithwick, M. ; Ager, E. ; Pask, A.J. ; Renfree, M.B. ; Kohn, M. ; Hameister, H. ; Nicholls, R.D. ; Deakin, J.E. ; Marshall Graves, J.A. / Recent assembly of an imprinted domain from non-imprinted components. In: PLoS Genetics. 2006 ; Vol. 2, No. 10. pp. 1666-1675.
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    abstract = "Genomic imprinting, representing parent-specific expression of alleles at a locus, raises many questions about how - and especially why - epigenetic silencing of mammalian genes evolved. We present the first in-depth study of how a human imprinted domain evolved, analyzing a domain containing several imprinted genes that are involved in human disease. Using comparisons of orthologous genes in humans, marsupials, and the platypus, we discovered that the Prader-Willi/Angelman syndrome region on human Chromosome 15q was assembled only recently (105-180 million years ago). This imprinted domain arose after a region bearing UBE3A (Angelman syndrome) fused with an unlinked region bearing SNRPN (Prader-Willi syndrome), which had duplicated from the non-imprinted SNRPB/B′. This region independently acquired several retroposed gene copies and arrays of small nucleolar RNAs from different parts of the genome. In their original configurations, SNRPN and UBE3A are expressed from both alleles, implying that acquisition of imprinting occurred after their rearrangement and required the evolution of a control locus. Thus, the evolution of imprinting in viviparous mammals is ongoing.",
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    Rapkins, RW, Hore, T, Smithwick, M, Ager, E, Pask, AJ, Renfree, MB, Kohn, M, Hameister, H, Nicholls, RD, Deakin, JE & Marshall Graves, JA 2006, 'Recent assembly of an imprinted domain from non-imprinted components', PLoS Genetics, vol. 2, no. 10, pp. 1666-1675. https://doi.org/10.1371/journal.pgen.0020182

    Recent assembly of an imprinted domain from non-imprinted components. / Rapkins, R.W.; Hore, T.; Smithwick, M.; Ager, E.; Pask, A.J.; Renfree, M.B.; Kohn, M.; Hameister, H.; Nicholls, R.D.; Deakin, J.E.; Marshall Graves, J.A.

    In: PLoS Genetics, Vol. 2, No. 10, 2006, p. 1666-1675.

    Research output: Contribution to journalArticle

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    Rapkins RW, Hore T, Smithwick M, Ager E, Pask AJ, Renfree MB et al. Recent assembly of an imprinted domain from non-imprinted components. PLoS Genetics. 2006;2(10):1666-1675. https://doi.org/10.1371/journal.pgen.0020182