Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 3204-3209 |
| Number of pages | 6 |
| Journal | Vaccine |
| Volume | 25 |
| Issue number | 16 |
| DOIs | |
| Publication status | Published - 2007 |
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Receptor mediated targeting of M-cells. / TYRER, Peter Charles; Foxwell, Ruth; KYD, Jenelle Maree; Otczyk, Diana; Cripps, Allan W.
In: Vaccine, Vol. 25, No. 16, 2007, p. 3204-3209.Research output: Contribution to journal › Article
TY - JOUR
T1 - Receptor mediated targeting of M-cells
AU - TYRER, Peter Charles
AU - Foxwell, Ruth
AU - KYD, Jenelle Maree
AU - Otczyk, Diana
AU - Cripps, Allan W.
PY - 2007
Y1 - 2007
N2 - The intestinal epithelium is a complex system of highly specialised cells that provide digestive and absorptive functions as well as innate and adaptive immunity. Induction of an adaptive immune response in the intestine can occur through the interaction of antigen with M-cells that overlay the lymphoid aggregates of the intestine (Peyer's patches). This study demonstrated that specific common microbial pathogen-associated molecular patterns are recognised by pattern recognition receptors on the surface of the M-cells and this interaction initiates transcytosis through the M-cell of particulate antigen from the intestinal milieu to underlying antigen presenting cells within the Peyer's patch. The study has found that among the pattern recognition molecules that have a role in recognising bacterial components, the apical expression of α5β1 integrin was important for the transcytotic function of M-cells. A proportion of intestinal enterocytes transform to an M-cell morphology in vitro, when cultured with Peyer's patch cells and our studies have demonstrated that CD4+ cells are integral for the development of M-cells in vitro
AB - The intestinal epithelium is a complex system of highly specialised cells that provide digestive and absorptive functions as well as innate and adaptive immunity. Induction of an adaptive immune response in the intestine can occur through the interaction of antigen with M-cells that overlay the lymphoid aggregates of the intestine (Peyer's patches). This study demonstrated that specific common microbial pathogen-associated molecular patterns are recognised by pattern recognition receptors on the surface of the M-cells and this interaction initiates transcytosis through the M-cell of particulate antigen from the intestinal milieu to underlying antigen presenting cells within the Peyer's patch. The study has found that among the pattern recognition molecules that have a role in recognising bacterial components, the apical expression of α5β1 integrin was important for the transcytotic function of M-cells. A proportion of intestinal enterocytes transform to an M-cell morphology in vitro, when cultured with Peyer's patch cells and our studies have demonstrated that CD4+ cells are integral for the development of M-cells in vitro
U2 - 10.1016/j.vaccine.2007.01.028
DO - 10.1016/j.vaccine.2007.01.028
M3 - Article
VL - 25
SP - 3204
EP - 3209
JO - Vaccine
JF - Vaccine
SN - 0264-410X
IS - 16
ER -