Receptor mediated targeting of M-cells

Peter Charles TYRER, Ruth Foxwell, Jenelle Maree KYD, Diana Otczyk, Allan W. Cripps

    Research output: Contribution to journalArticle

    35 Citations (Scopus)

    Abstract

    The intestinal epithelium is a complex system of highly specialised cells that provide digestive and absorptive functions as well as innate and adaptive immunity. Induction of an adaptive immune response in the intestine can occur through the interaction of antigen with M-cells that overlay the lymphoid aggregates of the intestine (Peyer's patches). This study demonstrated that specific common microbial pathogen-associated molecular patterns are recognised by pattern recognition receptors on the surface of the M-cells and this interaction initiates transcytosis through the M-cell of particulate antigen from the intestinal milieu to underlying antigen presenting cells within the Peyer's patch. The study has found that among the pattern recognition molecules that have a role in recognising bacterial components, the apical expression of α5β1 integrin was important for the transcytotic function of M-cells. A proportion of intestinal enterocytes transform to an M-cell morphology in vitro, when cultured with Peyer's patch cells and our studies have demonstrated that CD4+ cells are integral for the development of M-cells in vitro
    Original languageEnglish
    Pages (from-to)3204-3209
    Number of pages6
    JournalVaccine
    Volume25
    Issue number16
    DOIs
    Publication statusPublished - 2007

    Fingerprint

    receptors
    Peyer's Patches
    Peyer's patches
    cells
    Adaptive Immunity
    Intestines
    Transcytosis
    Pattern Recognition Receptors
    Antigens
    intestines
    Enterocytes
    physiological transport
    Antigen-Presenting Cells
    antigens
    Intestinal Mucosa
    Innate Immunity
    Integrins
    Cell Communication
    antigen-presenting cells
    enterocytes

    Cite this

    TYRER, P. C., Foxwell, R., KYD, J. M., Otczyk, D., & Cripps, A. W. (2007). Receptor mediated targeting of M-cells. Vaccine, 25(16), 3204-3209. https://doi.org/10.1016/j.vaccine.2007.01.028
    TYRER, Peter Charles ; Foxwell, Ruth ; KYD, Jenelle Maree ; Otczyk, Diana ; Cripps, Allan W. / Receptor mediated targeting of M-cells. In: Vaccine. 2007 ; Vol. 25, No. 16. pp. 3204-3209.
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    author = "TYRER, {Peter Charles} and Ruth Foxwell and KYD, {Jenelle Maree} and Diana Otczyk and Cripps, {Allan W.}",
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    TYRER, PC, Foxwell, R, KYD, JM, Otczyk, D & Cripps, AW 2007, 'Receptor mediated targeting of M-cells', Vaccine, vol. 25, no. 16, pp. 3204-3209. https://doi.org/10.1016/j.vaccine.2007.01.028

    Receptor mediated targeting of M-cells. / TYRER, Peter Charles; Foxwell, Ruth; KYD, Jenelle Maree; Otczyk, Diana; Cripps, Allan W.

    In: Vaccine, Vol. 25, No. 16, 2007, p. 3204-3209.

    Research output: Contribution to journalArticle

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    AU - TYRER, Peter Charles

    AU - Foxwell, Ruth

    AU - KYD, Jenelle Maree

    AU - Otczyk, Diana

    AU - Cripps, Allan W.

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    AB - The intestinal epithelium is a complex system of highly specialised cells that provide digestive and absorptive functions as well as innate and adaptive immunity. Induction of an adaptive immune response in the intestine can occur through the interaction of antigen with M-cells that overlay the lymphoid aggregates of the intestine (Peyer's patches). This study demonstrated that specific common microbial pathogen-associated molecular patterns are recognised by pattern recognition receptors on the surface of the M-cells and this interaction initiates transcytosis through the M-cell of particulate antigen from the intestinal milieu to underlying antigen presenting cells within the Peyer's patch. The study has found that among the pattern recognition molecules that have a role in recognising bacterial components, the apical expression of α5β1 integrin was important for the transcytotic function of M-cells. A proportion of intestinal enterocytes transform to an M-cell morphology in vitro, when cultured with Peyer's patch cells and our studies have demonstrated that CD4+ cells are integral for the development of M-cells in vitro

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    TYRER PC, Foxwell R, KYD JM, Otczyk D, Cripps AW. Receptor mediated targeting of M-cells. Vaccine. 2007;25(16):3204-3209. https://doi.org/10.1016/j.vaccine.2007.01.028