Repeated bouts of eccentrically biased endurance exercise stimulate salivary IgA secretion rate

Andrew MCKUNE, Dorota Starzak, Stuart SEMPLE

Research output: Contribution to journalArticle

6 Citations (Scopus)
3 Downloads (Pure)

Abstract

To determine the salivary secretory immunoglobulin A (sIgA) response to repeated bouts of unaccustomed, downhill running (eccentrically biased) and examine potential protective immunological adaption from a repeated bout effect. Eleven active but untrained males (age: 19.7±0.4 years; VO2peak: 47.8±3.6 ml kg-1 min -1) performed two 60 min bouts (Run 1 and Run 2) of downhill running (-13.5% gradient), separated by 14 days, at a speed eliciting 75% of their VO2peak on a level grade. Saliva samples were collected before (baseline), immediately post exercise (IPE), and every hour for 12 h and every 24 h for 6 days after each run. Salivary sIgA concentration was measured and sIgA secretion rate was calculated. Results were analysed using repeated measures ANOVA (12 h period: 2x14; 24 h intervals: 2x7; p = 0.05) with Tukey post-hoc tests where appropriate. Results are reported as means ± SE. There was a significant (p 0.0001) interaction effect for sIgA secretion rate, IPE, with higher values after Run 2, as well as a significant (p 0.01) time effect with elevated levels IPE and between 24 h and 144 h. There was a run effect (p 0.0001), with the sIgA secretion rate significantly higher after Run 2. Repeated bouts of unaccustomed, eccentrically biased exercise induced alterations in the salivary sIgA secretion rate. This may serve as a protective mucosal adaptation to exercise-induced tissue damage.
Original languageEnglish
Pages (from-to)21-25
Number of pages5
JournalBiology of Sport
Volume32
Issue number1
DOIs
Publication statusPublished - 2015

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Secretory Immunoglobulin A
Immunoglobulin A
Saliva
Analysis of Variance

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title = "Repeated bouts of eccentrically biased endurance exercise stimulate salivary IgA secretion rate",
abstract = "To determine the salivary secretory immunoglobulin A (sIgA) response to repeated bouts of unaccustomed, downhill running (eccentrically biased) and examine potential protective immunological adaption from a repeated bout effect. Eleven active but untrained males (age: 19.7±0.4 years; VO2peak: 47.8±3.6 ml kg-1 min -1) performed two 60 min bouts (Run 1 and Run 2) of downhill running (-13.5{\%} gradient), separated by 14 days, at a speed eliciting 75{\%} of their VO2peak on a level grade. Saliva samples were collected before (baseline), immediately post exercise (IPE), and every hour for 12 h and every 24 h for 6 days after each run. Salivary sIgA concentration was measured and sIgA secretion rate was calculated. Results were analysed using repeated measures ANOVA (12 h period: 2x14; 24 h intervals: 2x7; p = 0.05) with Tukey post-hoc tests where appropriate. Results are reported as means ± SE. There was a significant (p 0.0001) interaction effect for sIgA secretion rate, IPE, with higher values after Run 2, as well as a significant (p 0.01) time effect with elevated levels IPE and between 24 h and 144 h. There was a run effect (p 0.0001), with the sIgA secretion rate significantly higher after Run 2. Repeated bouts of unaccustomed, eccentrically biased exercise induced alterations in the salivary sIgA secretion rate. This may serve as a protective mucosal adaptation to exercise-induced tissue damage.",
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Repeated bouts of eccentrically biased endurance exercise stimulate salivary IgA secretion rate. / MCKUNE, Andrew; Starzak, Dorota; SEMPLE, Stuart.

In: Biology of Sport, Vol. 32, No. 1, 2015, p. 21-25.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Repeated bouts of eccentrically biased endurance exercise stimulate salivary IgA secretion rate

AU - MCKUNE, Andrew

AU - Starzak, Dorota

AU - SEMPLE, Stuart

PY - 2015

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N2 - To determine the salivary secretory immunoglobulin A (sIgA) response to repeated bouts of unaccustomed, downhill running (eccentrically biased) and examine potential protective immunological adaption from a repeated bout effect. Eleven active but untrained males (age: 19.7±0.4 years; VO2peak: 47.8±3.6 ml kg-1 min -1) performed two 60 min bouts (Run 1 and Run 2) of downhill running (-13.5% gradient), separated by 14 days, at a speed eliciting 75% of their VO2peak on a level grade. Saliva samples were collected before (baseline), immediately post exercise (IPE), and every hour for 12 h and every 24 h for 6 days after each run. Salivary sIgA concentration was measured and sIgA secretion rate was calculated. Results were analysed using repeated measures ANOVA (12 h period: 2x14; 24 h intervals: 2x7; p = 0.05) with Tukey post-hoc tests where appropriate. Results are reported as means ± SE. There was a significant (p 0.0001) interaction effect for sIgA secretion rate, IPE, with higher values after Run 2, as well as a significant (p 0.01) time effect with elevated levels IPE and between 24 h and 144 h. There was a run effect (p 0.0001), with the sIgA secretion rate significantly higher after Run 2. Repeated bouts of unaccustomed, eccentrically biased exercise induced alterations in the salivary sIgA secretion rate. This may serve as a protective mucosal adaptation to exercise-induced tissue damage.

AB - To determine the salivary secretory immunoglobulin A (sIgA) response to repeated bouts of unaccustomed, downhill running (eccentrically biased) and examine potential protective immunological adaption from a repeated bout effect. Eleven active but untrained males (age: 19.7±0.4 years; VO2peak: 47.8±3.6 ml kg-1 min -1) performed two 60 min bouts (Run 1 and Run 2) of downhill running (-13.5% gradient), separated by 14 days, at a speed eliciting 75% of their VO2peak on a level grade. Saliva samples were collected before (baseline), immediately post exercise (IPE), and every hour for 12 h and every 24 h for 6 days after each run. Salivary sIgA concentration was measured and sIgA secretion rate was calculated. Results were analysed using repeated measures ANOVA (12 h period: 2x14; 24 h intervals: 2x7; p = 0.05) with Tukey post-hoc tests where appropriate. Results are reported as means ± SE. There was a significant (p 0.0001) interaction effect for sIgA secretion rate, IPE, with higher values after Run 2, as well as a significant (p 0.01) time effect with elevated levels IPE and between 24 h and 144 h. There was a run effect (p 0.0001), with the sIgA secretion rate significantly higher after Run 2. Repeated bouts of unaccustomed, eccentrically biased exercise induced alterations in the salivary sIgA secretion rate. This may serve as a protective mucosal adaptation to exercise-induced tissue damage.

KW - Downhill running

KW - Mucosal immunity

KW - Muscle damage

KW - Repeated bout effect

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U2 - 10.5604/20831862.1126324

DO - 10.5604/20831862.1126324

M3 - Article

VL - 32

SP - 21

EP - 25

JO - Biology of Sport

JF - Biology of Sport

SN - 0860-021X

IS - 1

ER -