RHDV2 overcoming RHDV immunity in wild rabbits (Oryctolagus cuniculus) in Australia

David Peacock, John Kovaliski, Ron Sinclair, Greg Mutze, Amy Iannella, Lorenzo Capucci

    Research output: Contribution to journalArticle

    9 Citations (Scopus)

    Abstract

    THE emergence of rabbit haemorrhagic disease (RHDV) virus 2 (RHDV2) in Europe (Le Gall-Reculé and others 2011) has been associated with declines in wild rabbit ( Oryctolagus cuniculus ) populations (Delibes-Mateos and others 2014, Guerrero-Casado and others 2016, Monterroso and others 2016) previously exposed to RHDV. All RHDV genotypes of the G1–G6 genogroups, hereafter referred to as RHDV, belong to the same antigenic serotype (Le Gall-Reculé and others 2013). The unique antigenic nature of RHDV2 (Le Gall-Reculé and others 2013, Bárcena and others 2015) is reflected in its capacity to kill rabbits vaccinated against RHDV (Le Gall-Reculé and others 2011, Dalton and others 2014, McGowan and Choudhury 2016) and its rapid spread in Europe (Dalton and others 2012, Le Gall-Reculé and others 2013, Abrantes and others 2014, Baily and others 2014, Westcott and others 2014) and Australia (Hall and others 2015) with associated peaks in RHD epizootics. The capacity of RHDV2 to overcome RHDV immunity, reported so far only in vaccinated rabbits, may partly explain the observed decline in wild rabbit populations where RHDV had already been circulating. Here the authors report the infection by RHDV2 of three Australian wild rabbits with a known RHDV antibody-positive serological history, with clinical signs of RHD visible in one fresh carcase, the first documented cases of RHDV-immune wild rabbits being infected with and/or succumbing to RHDV2 infection. This demonstrated capacity of RHDV2 to overcome immunity derived from natural infections with RHDV supports an immunogenic difference between RHDV and RHDV2 at the level of serotype. With the emergence and spread of RHDV2 …
    Original languageEnglish
    Pages (from-to)1-3
    Number of pages3
    JournalVeterinary Record
    Volume180
    Issue number11
    DOIs
    Publication statusPublished - 2017

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    Oryctolagus cuniculus
    Immunity
    immunity
    rabbits
    Rabbits
    Viruses
    viruses
    Virus Diseases
    Rabbit Haemorrhagic Disease Virus
    serotypes
    Genotype
    infection
    Rabbit hemorrhagic disease virus
    Innate Immunity
    Population
    History
    history
    antibodies
    Antibodies
    genotype

    Cite this

    Peacock, D., Kovaliski, J., Sinclair, R., Mutze, G., Iannella, A., & Capucci, L. (2017). RHDV2 overcoming RHDV immunity in wild rabbits (Oryctolagus cuniculus) in Australia. Veterinary Record, 180(11), 1-3. https://doi.org/10.1136/vr.104135
    Peacock, David ; Kovaliski, John ; Sinclair, Ron ; Mutze, Greg ; Iannella, Amy ; Capucci, Lorenzo. / RHDV2 overcoming RHDV immunity in wild rabbits (Oryctolagus cuniculus) in Australia. In: Veterinary Record. 2017 ; Vol. 180, No. 11. pp. 1-3.
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    abstract = "THE emergence of rabbit haemorrhagic disease (RHDV) virus 2 (RHDV2) in Europe (Le Gall-Recul{\'e} and others 2011) has been associated with declines in wild rabbit ( Oryctolagus cuniculus ) populations (Delibes-Mateos and others 2014, Guerrero-Casado and others 2016, Monterroso and others 2016) previously exposed to RHDV. All RHDV genotypes of the G1–G6 genogroups, hereafter referred to as RHDV, belong to the same antigenic serotype (Le Gall-Recul{\'e} and others 2013). The unique antigenic nature of RHDV2 (Le Gall-Recul{\'e} and others 2013, B{\'a}rcena and others 2015) is reflected in its capacity to kill rabbits vaccinated against RHDV (Le Gall-Recul{\'e} and others 2011, Dalton and others 2014, McGowan and Choudhury 2016) and its rapid spread in Europe (Dalton and others 2012, Le Gall-Recul{\'e} and others 2013, Abrantes and others 2014, Baily and others 2014, Westcott and others 2014) and Australia (Hall and others 2015) with associated peaks in RHD epizootics. The capacity of RHDV2 to overcome RHDV immunity, reported so far only in vaccinated rabbits, may partly explain the observed decline in wild rabbit populations where RHDV had already been circulating. Here the authors report the infection by RHDV2 of three Australian wild rabbits with a known RHDV antibody-positive serological history, with clinical signs of RHD visible in one fresh carcase, the first documented cases of RHDV-immune wild rabbits being infected with and/or succumbing to RHDV2 infection. This demonstrated capacity of RHDV2 to overcome immunity derived from natural infections with RHDV supports an immunogenic difference between RHDV and RHDV2 at the level of serotype. With the emergence and spread of RHDV2 …",
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    Peacock, D, Kovaliski, J, Sinclair, R, Mutze, G, Iannella, A & Capucci, L 2017, 'RHDV2 overcoming RHDV immunity in wild rabbits (Oryctolagus cuniculus) in Australia', Veterinary Record, vol. 180, no. 11, pp. 1-3. https://doi.org/10.1136/vr.104135

    RHDV2 overcoming RHDV immunity in wild rabbits (Oryctolagus cuniculus) in Australia. / Peacock, David; Kovaliski, John; Sinclair, Ron; Mutze, Greg; Iannella, Amy; Capucci, Lorenzo.

    In: Veterinary Record, Vol. 180, No. 11, 2017, p. 1-3.

    Research output: Contribution to journalArticle

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    AU - Peacock, David

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    AU - Iannella, Amy

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    Peacock D, Kovaliski J, Sinclair R, Mutze G, Iannella A, Capucci L. RHDV2 overcoming RHDV immunity in wild rabbits (Oryctolagus cuniculus) in Australia. Veterinary Record. 2017;180(11):1-3. https://doi.org/10.1136/vr.104135