Rhodium-Catalysed Enantioselective C-H Functionalization in Asymmetric Synthesis

Somayeh Motevalli, Yasser Sokeirik, Ashraf GHANEM

Research output: Contribution to journalReview article

120 Citations (Scopus)

Abstract

In this review, recent advances in the utilization of two classes of rhodium catalysts - namely rhodium(I) and rhodium(III) - in complexation with chiral cyclopentadienyl and phosphorus ligands in inter- A nd intramolecular asymmetric C-H bond activation/functionalization of aromatic and vinylic compounds is discussed. Because Rh complexes have been shown to be excellent catalysts for enantioselective alkylation, olefination and allylation of π systems through directed C-H functionalization under very mild conditions, this method has been seen to have broad synthetic potential both in organic chemistry and in biological systems. Moreover, selective conversion of ubiquitous C-H bonds into functional groups without intermediate preactivation is useful for shortening reaction sequences, with high environmental and economic benefits.

Original languageEnglish
Pages (from-to)1459-1475
Number of pages17
JournalEuropean Journal of Organic Chemistry
Volume2016
Issue number8
DOIs
Publication statusPublished - 1 Mar 2016

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