Role of chemokines in shaping macrophage activity in AMD

Matt Rutar, Jan M. Provis

Research output: A Conference proceeding or a Chapter in BookOther chapter contributionpeer-review

16 Citations (Scopus)


Age-related macular degeneration (AMD) is a multifactorial disorder that affects millions of individuals worldwide. While the advent of anti-VEGF therapy has allowed for effective treatment of neovascular ‘wet’ AMD, no treatments are available to mitigate the more prevalent ‘dry’ forms of the disease. A role for inflammatory processes in the progression of AMD has emerged over a period of many years, particularly the characterisation of leukocyte infiltrates in AMDaffected eyes, as well as in animal models. This review focuses on the burgeoning understanding of chemokines in the retina, and their potential role in shaping the recruitment and activation of macrophages in AMD. Understanding the mechanisms which promote macrophage activity in the degenerating retina may be key to controlling the potentially devastating consequences of inflammation in diseases such as AMD.

Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
EditorsCatherine Bowes Rickman, Matthew M. LaVail, Robert E. Anderson, Christian Grimm, Joe Hollyfield, John Ash
Place of PublicationUnited States
Number of pages6
ISBN (Electronic)9783319171210
ISBN (Print)9783319171203
Publication statusPublished - 1 Oct 2016
Externally publishedYes

Publication series

NameAdvances in Experimental Medicine and Biology
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019


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