TY - JOUR
T1 - SARS-CoV-2 infection during pregnancy and pregnancy-related conditions: Concerns, challenges, management and mitigation strategies-a narrative review
AU - Kumar, Rakesh
AU - Yeni, Cut Meurah
AU - Utami, Niken Asri
AU - Masand, Rupali
AU - Asrani, Rajesh Kumar
AU - Patel, Shailesh Kumar
AU - Kumar, Akshay
AU - Yatoo, Mohd Iqbal
AU - Tiwari, Ruchi
AU - Natesan, Senthilkumar
AU - Vora, Kranti Suresh
AU - Nainu, Firzan
AU - Bilal, Muhammad
AU - Dhawan, Manish
AU - Bin Emran, Talha
AU - Ahmad, Tauseef
AU - Harapan, Harapan
AU - Dhama, Kuldeep
N1 - Funding Information:
All the authors acknowledge and thank their respective institutes and universities.
Publisher Copyright:
© 2021 The Author(s)
PY - 2021/7
Y1 - 2021/7
N2 - The ongoing coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a global public health problem. The SARS-CoV-2 triggers hyper-activation of inflammatory and immune responses resulting in cytokine storm and increased inflammatory responses on several organs like lungs, kidneys, intestine, and placenta. Although SARS-CoV-2 affects individuals of all age groups and physiological statuses, immune-compromised individuals such as pregnant women are considered as a highly vulnerable group. This review aims to raise the concerns of high risk of infection, morbidity and mortality of COVID-19 in pregnant women and provides critical reviews of pathophysiology and pathobiology of how SARS-CoV-2 infection potentially increases the severity and fatality during pregnancy. This article also provides a discussion of current evidence on vertical transmission of SARS-CoV-2 during pregnancy and breastfeeding. Lastly, guidelines on management, treatment, preventive, and mitigation strategies of SARS-CoV-2 infection during pregnancy and pregnancy-related conditions such as delivery and breastfeeding are discussed.
AB - The ongoing coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a global public health problem. The SARS-CoV-2 triggers hyper-activation of inflammatory and immune responses resulting in cytokine storm and increased inflammatory responses on several organs like lungs, kidneys, intestine, and placenta. Although SARS-CoV-2 affects individuals of all age groups and physiological statuses, immune-compromised individuals such as pregnant women are considered as a highly vulnerable group. This review aims to raise the concerns of high risk of infection, morbidity and mortality of COVID-19 in pregnant women and provides critical reviews of pathophysiology and pathobiology of how SARS-CoV-2 infection potentially increases the severity and fatality during pregnancy. This article also provides a discussion of current evidence on vertical transmission of SARS-CoV-2 during pregnancy and breastfeeding. Lastly, guidelines on management, treatment, preventive, and mitigation strategies of SARS-CoV-2 infection during pregnancy and pregnancy-related conditions such as delivery and breastfeeding are discussed.
KW - COVID-19
KW - SARS-CoV-2
KW - Pregnant women
KW - Vertical transmission
KW - Prevention
UR - http://www.scopus.com/inward/record.url?scp=85108114523&partnerID=8YFLogxK
U2 - 10.1016/j.jiph.2021.04.005
DO - 10.1016/j.jiph.2021.04.005
M3 - Review article
SN - 1876-0341
VL - 14
SP - 863
EP - 875
JO - Journal of Infection and Public Health
JF - Journal of Infection and Public Health
IS - 7
ER -
