TY - JOUR
T1 - Searching for the biological pathways between stress and health
AU - Kelly, Shona
AU - Hertzman, Clyde
AU - Daniels, Mark
PY - 1997/5
Y1 - 1997/5
N2 - Population-based, person-specific health surveys, with concomitant biological measures, should provide important information about the processes by which socioeconomic and psychosocial factors embed themselves in human health. Questionnaire responses allow for assessment of the perceived psychosocial environment, but biological measurements will measure the status of the psychoneuroimmunology/psychoneuroendocrinology (PNI/PNE) pathways and may allow us to identify people who have 'adapted' to their stress because of experience, expectations, stoicism, etc. This review sets criteria to evaluate potential physiological markers of chronic stress. Because population health surveys involve a massive number of samples, special consideration must be given to the laboratory analysis method and transportation time of the markers chosen. We reviewed five areas: glycosylated proteins, the immune system, hemostasis, peripheral benzodiazepine receptors, and the waist-hip ratio.
AB - Population-based, person-specific health surveys, with concomitant biological measures, should provide important information about the processes by which socioeconomic and psychosocial factors embed themselves in human health. Questionnaire responses allow for assessment of the perceived psychosocial environment, but biological measurements will measure the status of the psychoneuroimmunology/psychoneuroendocrinology (PNI/PNE) pathways and may allow us to identify people who have 'adapted' to their stress because of experience, expectations, stoicism, etc. This review sets criteria to evaluate potential physiological markers of chronic stress. Because population health surveys involve a massive number of samples, special consideration must be given to the laboratory analysis method and transportation time of the markers chosen. We reviewed five areas: glycosylated proteins, the immune system, hemostasis, peripheral benzodiazepine receptors, and the waist-hip ratio.
KW - hematologic tests
KW - hemostasis
KW - psychological stress
KW - psychoneuroimmunology
KW - socioeconomic factors
UR - http://www.scopus.com/inward/record.url?scp=0030902556&partnerID=8YFLogxK
U2 - 10.1146/annurev.publhealth.18.1.437
DO - 10.1146/annurev.publhealth.18.1.437
M3 - Review article
C2 - 9143726
AN - SCOPUS:0030902556
SN - 0163-7525
VL - 18
SP - 437
EP - 462
JO - Annual Review of Public Health
JF - Annual Review of Public Health
ER -