Selective and Graded Recruitment of Cat Hamstring Muscles with Intrafascicular Stimulation

Brett R. Dowden, Andrew M. Wilder, Scott D. Hiatt, Richard A. Normann, Nicholas A.T. Brown, Gregory A. Clark

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The muscles of the hamstring group can produce different combinations of hip and knee torque. Thus, the ability to activate the different hamstring muscles selectively is of particular importance in eliciting functional movements such as stance and gait in a person with spinal cord injury.We investigated the ability of intrafascicular stimulation of the muscular branch of the sciatic nerve to recruit the feline hamstring muscles in a selective and graded fashion. A Utah Slanted Electrode Array, consisting of 100 penetrating microelectrodes, was implanted into the muscular branch of the sciatic nerve in six cats. Muscle twitches were evoked in the three compartments of biceps femoris (anterior, middle, and posterior), as well as semitendinosus and semimembranosus, using pulse-width modulated constant-voltage pulses. The resultant compound muscle action potentials were recorded using intramuscular fine-wire electrodes. 74% of the electrodes per implant were able to evoke a threshold response in these muscles, and these electrodes were evenly distributed among the instrumented muscles. Of the five muscles instrumented, on average 2.5 could be selectively activated to 90% of maximum EMG, and 3.5 could be selectively activated to 50% of maximum EMG. The muscles were recruited selectively with a mean stimulus dynamic range of 4.14 5.05 dB between threshold and either spillover to another muscle or a plateau in the response. This selective and graded activation afforded by intrafascicular stimulation of the muscular branch of the sciatic nerve suggests that it is a potentially useful stimulation paradigm for eliciting distinct forces in the hamstring muscle group in motor neuroprosthetic applications.

Original languageEnglish
Article number5208177
Pages (from-to)545-552
Number of pages8
JournalIEEE Transactions on Neural Systems and Rehabilitation Engineering
Volume17
Issue number6
DOIs
Publication statusPublished - 1 Dec 2009
Externally publishedYes

Fingerprint

Muscle
Cats
Muscles
Electrodes
Sciatic Nerve
Felidae
Torque
Microelectrodes
Hamstring Muscles
Spinal Cord Injuries
Gait
Action Potentials
Hip
Knee
Chemical activation
Wire
Electric potential

Cite this

Dowden, Brett R. ; Wilder, Andrew M. ; Hiatt, Scott D. ; Normann, Richard A. ; Brown, Nicholas A.T. ; Clark, Gregory A. / Selective and Graded Recruitment of Cat Hamstring Muscles with Intrafascicular Stimulation. In: IEEE Transactions on Neural Systems and Rehabilitation Engineering. 2009 ; Vol. 17, No. 6. pp. 545-552.
@article{146e08e1d70a4450b019b2118b158d43,
title = "Selective and Graded Recruitment of Cat Hamstring Muscles with Intrafascicular Stimulation",
abstract = "The muscles of the hamstring group can produce different combinations of hip and knee torque. Thus, the ability to activate the different hamstring muscles selectively is of particular importance in eliciting functional movements such as stance and gait in a person with spinal cord injury.We investigated the ability of intrafascicular stimulation of the muscular branch of the sciatic nerve to recruit the feline hamstring muscles in a selective and graded fashion. A Utah Slanted Electrode Array, consisting of 100 penetrating microelectrodes, was implanted into the muscular branch of the sciatic nerve in six cats. Muscle twitches were evoked in the three compartments of biceps femoris (anterior, middle, and posterior), as well as semitendinosus and semimembranosus, using pulse-width modulated constant-voltage pulses. The resultant compound muscle action potentials were recorded using intramuscular fine-wire electrodes. 74{\%} of the electrodes per implant were able to evoke a threshold response in these muscles, and these electrodes were evenly distributed among the instrumented muscles. Of the five muscles instrumented, on average 2.5 could be selectively activated to 90{\%} of maximum EMG, and 3.5 could be selectively activated to 50{\%} of maximum EMG. The muscles were recruited selectively with a mean stimulus dynamic range of 4.14 5.05 dB between threshold and either spillover to another muscle or a plateau in the response. This selective and graded activation afforded by intrafascicular stimulation of the muscular branch of the sciatic nerve suggests that it is a potentially useful stimulation paradigm for eliciting distinct forces in the hamstring muscle group in motor neuroprosthetic applications.",
keywords = "Feline hamstring muscles, Intrafascicular stimulation, Motor neuroprosthesis, Neuromuscular stimulation, Selective activation",
author = "Dowden, {Brett R.} and Wilder, {Andrew M.} and Hiatt, {Scott D.} and Normann, {Richard A.} and Brown, {Nicholas A.T.} and Clark, {Gregory A.}",
year = "2009",
month = "12",
day = "1",
doi = "10.1109/TNSRE.2008.2011988",
language = "English",
volume = "17",
pages = "545--552",
journal = "IEEE Transactions on Rehabilitation Engineering",
issn = "1534-4320",
publisher = "IEEE, Institute of Electrical and Electronics Engineers",
number = "6",

}

Selective and Graded Recruitment of Cat Hamstring Muscles with Intrafascicular Stimulation. / Dowden, Brett R.; Wilder, Andrew M.; Hiatt, Scott D.; Normann, Richard A.; Brown, Nicholas A.T.; Clark, Gregory A.

In: IEEE Transactions on Neural Systems and Rehabilitation Engineering, Vol. 17, No. 6, 5208177, 01.12.2009, p. 545-552.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Selective and Graded Recruitment of Cat Hamstring Muscles with Intrafascicular Stimulation

AU - Dowden, Brett R.

AU - Wilder, Andrew M.

AU - Hiatt, Scott D.

AU - Normann, Richard A.

AU - Brown, Nicholas A.T.

AU - Clark, Gregory A.

PY - 2009/12/1

Y1 - 2009/12/1

N2 - The muscles of the hamstring group can produce different combinations of hip and knee torque. Thus, the ability to activate the different hamstring muscles selectively is of particular importance in eliciting functional movements such as stance and gait in a person with spinal cord injury.We investigated the ability of intrafascicular stimulation of the muscular branch of the sciatic nerve to recruit the feline hamstring muscles in a selective and graded fashion. A Utah Slanted Electrode Array, consisting of 100 penetrating microelectrodes, was implanted into the muscular branch of the sciatic nerve in six cats. Muscle twitches were evoked in the three compartments of biceps femoris (anterior, middle, and posterior), as well as semitendinosus and semimembranosus, using pulse-width modulated constant-voltage pulses. The resultant compound muscle action potentials were recorded using intramuscular fine-wire electrodes. 74% of the electrodes per implant were able to evoke a threshold response in these muscles, and these electrodes were evenly distributed among the instrumented muscles. Of the five muscles instrumented, on average 2.5 could be selectively activated to 90% of maximum EMG, and 3.5 could be selectively activated to 50% of maximum EMG. The muscles were recruited selectively with a mean stimulus dynamic range of 4.14 5.05 dB between threshold and either spillover to another muscle or a plateau in the response. This selective and graded activation afforded by intrafascicular stimulation of the muscular branch of the sciatic nerve suggests that it is a potentially useful stimulation paradigm for eliciting distinct forces in the hamstring muscle group in motor neuroprosthetic applications.

AB - The muscles of the hamstring group can produce different combinations of hip and knee torque. Thus, the ability to activate the different hamstring muscles selectively is of particular importance in eliciting functional movements such as stance and gait in a person with spinal cord injury.We investigated the ability of intrafascicular stimulation of the muscular branch of the sciatic nerve to recruit the feline hamstring muscles in a selective and graded fashion. A Utah Slanted Electrode Array, consisting of 100 penetrating microelectrodes, was implanted into the muscular branch of the sciatic nerve in six cats. Muscle twitches were evoked in the three compartments of biceps femoris (anterior, middle, and posterior), as well as semitendinosus and semimembranosus, using pulse-width modulated constant-voltage pulses. The resultant compound muscle action potentials were recorded using intramuscular fine-wire electrodes. 74% of the electrodes per implant were able to evoke a threshold response in these muscles, and these electrodes were evenly distributed among the instrumented muscles. Of the five muscles instrumented, on average 2.5 could be selectively activated to 90% of maximum EMG, and 3.5 could be selectively activated to 50% of maximum EMG. The muscles were recruited selectively with a mean stimulus dynamic range of 4.14 5.05 dB between threshold and either spillover to another muscle or a plateau in the response. This selective and graded activation afforded by intrafascicular stimulation of the muscular branch of the sciatic nerve suggests that it is a potentially useful stimulation paradigm for eliciting distinct forces in the hamstring muscle group in motor neuroprosthetic applications.

KW - Feline hamstring muscles

KW - Intrafascicular stimulation

KW - Motor neuroprosthesis

KW - Neuromuscular stimulation

KW - Selective activation

UR - http://www.scopus.com/inward/record.url?scp=74549129480&partnerID=8YFLogxK

U2 - 10.1109/TNSRE.2008.2011988

DO - 10.1109/TNSRE.2008.2011988

M3 - Article

VL - 17

SP - 545

EP - 552

JO - IEEE Transactions on Rehabilitation Engineering

JF - IEEE Transactions on Rehabilitation Engineering

SN - 1534-4320

IS - 6

M1 - 5208177

ER -