Sensitivity of blood lipids to changes in adiposity, exercise, and diet in children

Dick TELFORD, Ross Cunningham, Paul Waring, Rohan Telford, Julia Potter, Peter Hickman, Walter P. Abhayaratna

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Purpose: This study aims to determine whether blood lipids in healthy preadolescent children are sensitive to normally occurring changes in percent body fat, physical activity (PA), cardiorespiratory fitness (CRF), and macronutrient intake. Methods: Repeatedmeasurements of fasting serum LDL cholesterol, HDL cholesterol, and triglycerides (TG); percent body fat (dual-energy X-ray absorptiometry); PA(pedometers); CRF (multistage run); and carbohydrate, sugar, and fat intake (dietary recall and record) were carried out in 469 children (51% girls) age 8, 10, and 12 yr. Results: Longitudinal relationships in boys showed that, for every one-unit increase in percent body fat, there was a 1.3% (95% CI, 0.9-1.8; P G 0.001) increase in LDL cholesterol; among girls, the increase was 0.8% (95% CI, 0.3-1.2; P = 0.003). In addition, we found a positive longitudinal relationship between TG and percent body fat (P G 0.001) in girls, and a negative longitudinal relationship between HDL cholesterol and percent body fat (P = 0.03) in boys. There were also longitudinal relationships between TG and CRF in both sexes (P G 0.05), but these were not sustained upon adjustment for percent body fat. Although cross-sectional relationships occurred in girls for both HDL cholesterol and TG with PA (P G 0.05), we found no evidence of any relationships between lipids and fat or sugar intake. By age 12 yr, LDL cholesterol was elevated (93.36 mmolILj1) in 16% and 20% of girls and boys, respectively. Conclusions: Blood lipids in preadolescent children appear sensitive to normal changes occurring in their percent body fat and, thus, fitness. Our data support early attention to body composition in community strategies designed to prevent cardiovascular disease in later life
Original languageEnglish
Pages (from-to)974-982
Number of pages9
JournalMedicine and Science in Sports and Exercise
Volume47
Issue number5
DOIs
Publication statusPublished - 2015

Fingerprint

Adiposity
Adipose Tissue
Exercise
Diet
Lipids
Triglycerides
LDL Cholesterol
HDL Cholesterol
Fats
Diet Records
Photon Absorptiometry
Body Composition
Fasting
Cardiovascular Diseases
Carbohydrates
Serum
Cardiorespiratory Fitness

Cite this

TELFORD, Dick ; Cunningham, Ross ; Waring, Paul ; Telford, Rohan ; Potter, Julia ; Hickman, Peter ; Abhayaratna, Walter P. / Sensitivity of blood lipids to changes in adiposity, exercise, and diet in children. In: Medicine and Science in Sports and Exercise. 2015 ; Vol. 47, No. 5. pp. 974-982.
@article{2eca5099c4504240b6c7a615ccde6984,
title = "Sensitivity of blood lipids to changes in adiposity, exercise, and diet in children",
abstract = "Purpose: This study aims to determine whether blood lipids in healthy preadolescent children are sensitive to normally occurring changes in percent body fat, physical activity (PA), cardiorespiratory fitness (CRF), and macronutrient intake. Methods: Repeatedmeasurements of fasting serum LDL cholesterol, HDL cholesterol, and triglycerides (TG); percent body fat (dual-energy X-ray absorptiometry); PA(pedometers); CRF (multistage run); and carbohydrate, sugar, and fat intake (dietary recall and record) were carried out in 469 children (51{\%} girls) age 8, 10, and 12 yr. Results: Longitudinal relationships in boys showed that, for every one-unit increase in percent body fat, there was a 1.3{\%} (95{\%} CI, 0.9-1.8; P G 0.001) increase in LDL cholesterol; among girls, the increase was 0.8{\%} (95{\%} CI, 0.3-1.2; P = 0.003). In addition, we found a positive longitudinal relationship between TG and percent body fat (P G 0.001) in girls, and a negative longitudinal relationship between HDL cholesterol and percent body fat (P = 0.03) in boys. There were also longitudinal relationships between TG and CRF in both sexes (P G 0.05), but these were not sustained upon adjustment for percent body fat. Although cross-sectional relationships occurred in girls for both HDL cholesterol and TG with PA (P G 0.05), we found no evidence of any relationships between lipids and fat or sugar intake. By age 12 yr, LDL cholesterol was elevated (93.36 mmolILj1) in 16{\%} and 20{\%} of girls and boys, respectively. Conclusions: Blood lipids in preadolescent children appear sensitive to normal changes occurring in their percent body fat and, thus, fitness. Our data support early attention to body composition in community strategies designed to prevent cardiovascular disease in later life",
keywords = "Bmi, Children, Cholesterol, Longitudinal, Percent Body Fat, Physical Activity",
author = "Dick TELFORD and Ross Cunningham and Paul Waring and Rohan Telford and Julia Potter and Peter Hickman and Abhayaratna, {Walter P.}",
year = "2015",
doi = "10.1249/MSS.0000000000000493",
language = "English",
volume = "47",
pages = "974--982",
journal = "Medicine Science in Sports Exercise",
issn = "0195-9131",
publisher = "Lippincott Williams and Wilkins",
number = "5",

}

Sensitivity of blood lipids to changes in adiposity, exercise, and diet in children. / TELFORD, Dick; Cunningham, Ross; Waring, Paul; Telford, Rohan; Potter, Julia; Hickman, Peter; Abhayaratna, Walter P.

In: Medicine and Science in Sports and Exercise, Vol. 47, No. 5, 2015, p. 974-982.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Sensitivity of blood lipids to changes in adiposity, exercise, and diet in children

AU - TELFORD, Dick

AU - Cunningham, Ross

AU - Waring, Paul

AU - Telford, Rohan

AU - Potter, Julia

AU - Hickman, Peter

AU - Abhayaratna, Walter P.

PY - 2015

Y1 - 2015

N2 - Purpose: This study aims to determine whether blood lipids in healthy preadolescent children are sensitive to normally occurring changes in percent body fat, physical activity (PA), cardiorespiratory fitness (CRF), and macronutrient intake. Methods: Repeatedmeasurements of fasting serum LDL cholesterol, HDL cholesterol, and triglycerides (TG); percent body fat (dual-energy X-ray absorptiometry); PA(pedometers); CRF (multistage run); and carbohydrate, sugar, and fat intake (dietary recall and record) were carried out in 469 children (51% girls) age 8, 10, and 12 yr. Results: Longitudinal relationships in boys showed that, for every one-unit increase in percent body fat, there was a 1.3% (95% CI, 0.9-1.8; P G 0.001) increase in LDL cholesterol; among girls, the increase was 0.8% (95% CI, 0.3-1.2; P = 0.003). In addition, we found a positive longitudinal relationship between TG and percent body fat (P G 0.001) in girls, and a negative longitudinal relationship between HDL cholesterol and percent body fat (P = 0.03) in boys. There were also longitudinal relationships between TG and CRF in both sexes (P G 0.05), but these were not sustained upon adjustment for percent body fat. Although cross-sectional relationships occurred in girls for both HDL cholesterol and TG with PA (P G 0.05), we found no evidence of any relationships between lipids and fat or sugar intake. By age 12 yr, LDL cholesterol was elevated (93.36 mmolILj1) in 16% and 20% of girls and boys, respectively. Conclusions: Blood lipids in preadolescent children appear sensitive to normal changes occurring in their percent body fat and, thus, fitness. Our data support early attention to body composition in community strategies designed to prevent cardiovascular disease in later life

AB - Purpose: This study aims to determine whether blood lipids in healthy preadolescent children are sensitive to normally occurring changes in percent body fat, physical activity (PA), cardiorespiratory fitness (CRF), and macronutrient intake. Methods: Repeatedmeasurements of fasting serum LDL cholesterol, HDL cholesterol, and triglycerides (TG); percent body fat (dual-energy X-ray absorptiometry); PA(pedometers); CRF (multistage run); and carbohydrate, sugar, and fat intake (dietary recall and record) were carried out in 469 children (51% girls) age 8, 10, and 12 yr. Results: Longitudinal relationships in boys showed that, for every one-unit increase in percent body fat, there was a 1.3% (95% CI, 0.9-1.8; P G 0.001) increase in LDL cholesterol; among girls, the increase was 0.8% (95% CI, 0.3-1.2; P = 0.003). In addition, we found a positive longitudinal relationship between TG and percent body fat (P G 0.001) in girls, and a negative longitudinal relationship between HDL cholesterol and percent body fat (P = 0.03) in boys. There were also longitudinal relationships between TG and CRF in both sexes (P G 0.05), but these were not sustained upon adjustment for percent body fat. Although cross-sectional relationships occurred in girls for both HDL cholesterol and TG with PA (P G 0.05), we found no evidence of any relationships between lipids and fat or sugar intake. By age 12 yr, LDL cholesterol was elevated (93.36 mmolILj1) in 16% and 20% of girls and boys, respectively. Conclusions: Blood lipids in preadolescent children appear sensitive to normal changes occurring in their percent body fat and, thus, fitness. Our data support early attention to body composition in community strategies designed to prevent cardiovascular disease in later life

KW - Bmi

KW - Children

KW - Cholesterol

KW - Longitudinal

KW - Percent Body Fat

KW - Physical Activity

U2 - 10.1249/MSS.0000000000000493

DO - 10.1249/MSS.0000000000000493

M3 - Article

VL - 47

SP - 974

EP - 982

JO - Medicine Science in Sports Exercise

JF - Medicine Science in Sports Exercise

SN - 0195-9131

IS - 5

ER -