Serodiagnosis of toxoplasmosis in a common wombat. Journal of Wildlife Diseases

Lee Skerrat, Jim Phelan, Ro MCFARLANE, Rick Speare

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

An 8-yr-old captive, female common wombat (Vombatus ursinus) from Victoria, Australia was euthanased after an illness of 36 days manifested by lethargy, inappetance and terminal coma with respiratory failure. Toxoplasmosis was diagnosed during life by the Toxoplasma direct agglutination test (DAT) which showed a positive initial titre of 1:1,024 at 22 days after onset of illness and a four fold rise in titre to 1:4,098 2 wk later, just prior to death. The Toxoplasma modified agglutination test (MAT) remained negative over this time period. The serological diagnosis was confirmed by histological diagnosis of granulomatous encephalitis, focal myocarditis, interstitial pneumonia and severe adrenal cortical necrosis and the presence of tachyzoites of Toxoplasma gondii in large numbers within the focal necrotic lesions in the brain, myocardium and adrenal cortices. The serological response in the wombat differed from that of the typical eutherian which exhibits a reaction in both the DAT and MAT within 2 wk of infection with T. gondii. An incidental finding was calcification in the media of the ascending aorta and proximal parts of the major arteries.
Original languageEnglish
Pages (from-to)346-351
Number of pages7
JournalJournal of Wildlife Diseases
Volume33
Issue number2
Publication statusPublished - 1997
Externally publishedYes

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wildlife diseases
serodiagnosis
toxoplasmosis
agglutination tests
Toxoplasma
Toxoplasma gondii
Victoria (Australia)
encephalitis
coma
myocarditis
adrenal cortex
tachyzoites
pneumonia
calcification
myocardium
aorta
lesion
lesions (animal)
arteries
brain

Cite this

Skerrat, Lee ; Phelan, Jim ; MCFARLANE, Ro ; Speare, Rick. / Serodiagnosis of toxoplasmosis in a common wombat. Journal of Wildlife Diseases. In: Journal of Wildlife Diseases. 1997 ; Vol. 33, No. 2. pp. 346-351.
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abstract = "An 8-yr-old captive, female common wombat (Vombatus ursinus) from Victoria, Australia was euthanased after an illness of 36 days manifested by lethargy, inappetance and terminal coma with respiratory failure. Toxoplasmosis was diagnosed during life by the Toxoplasma direct agglutination test (DAT) which showed a positive initial titre of 1:1,024 at 22 days after onset of illness and a four fold rise in titre to 1:4,098 2 wk later, just prior to death. The Toxoplasma modified agglutination test (MAT) remained negative over this time period. The serological diagnosis was confirmed by histological diagnosis of granulomatous encephalitis, focal myocarditis, interstitial pneumonia and severe adrenal cortical necrosis and the presence of tachyzoites of Toxoplasma gondii in large numbers within the focal necrotic lesions in the brain, myocardium and adrenal cortices. The serological response in the wombat differed from that of the typical eutherian which exhibits a reaction in both the DAT and MAT within 2 wk of infection with T. gondii. An incidental finding was calcification in the media of the ascending aorta and proximal parts of the major arteries.",
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Serodiagnosis of toxoplasmosis in a common wombat. Journal of Wildlife Diseases. / Skerrat, Lee; Phelan, Jim; MCFARLANE, Ro; Speare, Rick.

In: Journal of Wildlife Diseases, Vol. 33, No. 2, 1997, p. 346-351.

Research output: Contribution to journalArticle

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AB - An 8-yr-old captive, female common wombat (Vombatus ursinus) from Victoria, Australia was euthanased after an illness of 36 days manifested by lethargy, inappetance and terminal coma with respiratory failure. Toxoplasmosis was diagnosed during life by the Toxoplasma direct agglutination test (DAT) which showed a positive initial titre of 1:1,024 at 22 days after onset of illness and a four fold rise in titre to 1:4,098 2 wk later, just prior to death. The Toxoplasma modified agglutination test (MAT) remained negative over this time period. The serological diagnosis was confirmed by histological diagnosis of granulomatous encephalitis, focal myocarditis, interstitial pneumonia and severe adrenal cortical necrosis and the presence of tachyzoites of Toxoplasma gondii in large numbers within the focal necrotic lesions in the brain, myocardium and adrenal cortices. The serological response in the wombat differed from that of the typical eutherian which exhibits a reaction in both the DAT and MAT within 2 wk of infection with T. gondii. An incidental finding was calcification in the media of the ascending aorta and proximal parts of the major arteries.

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