SETDB-1: A potential epigenetic regulator in breast cancer metastasis

Jacob Batham, Pek Siew Lim, Sudha Rao

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Abstract

The full epigenetic repertoire governing breast cancer metastasis is not completely understood. Here, we discuss the histone methyltransferase SET Domain Bifurcated Histone Lysine Methyltransferase 1 (SETDB1) and its role in breast cancer metastasis. SETDB1 serves as an exemplar of the difficulties faced when developing therapies that not only specifically target cancer cells but also the more elusive and aggressive stem cells that contribute to metastasis via epithelialto-mesenchymal transition and confer resistance to therapies.

Original languageEnglish
Article number1143
Pages (from-to)1-20
Number of pages20
JournalCancers
Volume11
Issue number8
DOIs
Publication statusPublished - 9 Aug 2019

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