SETDB-1: A potential epigenetic regulator in breast cancer metastasis

Jacob Batham, Pek Siew Lim, Sudha Rao

Research output: Contribution to journalReview article

Abstract

The full epigenetic repertoire governing breast cancer metastasis is not completely understood. Here, we discuss the histone methyltransferase SET Domain Bifurcated Histone Lysine Methyltransferase 1 (SETDB1) and its role in breast cancer metastasis. SETDB1 serves as an exemplar of the difficulties faced when developing therapies that not only specifically target cancer cells but also the more elusive and aggressive stem cells that contribute to metastasis via epithelialto-mesenchymal transition and confer resistance to therapies.

Original languageEnglish
Article number1143
Pages (from-to)1-20
Number of pages20
JournalCancers
Volume11
Issue number8
DOIs
Publication statusPublished - 9 Aug 2019

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Histone-Lysine N-Methyltransferase
Epigenomics
Breast Neoplasms
Neoplasm Metastasis
Stem Cells
Therapeutics
Neoplasms

Cite this

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title = "SETDB-1: A potential epigenetic regulator in breast cancer metastasis",
abstract = "The full epigenetic repertoire governing breast cancer metastasis is not completely understood. Here, we discuss the histone methyltransferase SET Domain Bifurcated Histone Lysine Methyltransferase 1 (SETDB1) and its role in breast cancer metastasis. SETDB1 serves as an exemplar of the difficulties faced when developing therapies that not only specifically target cancer cells but also the more elusive and aggressive stem cells that contribute to metastasis via epithelialto-mesenchymal transition and confer resistance to therapies.",
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SETDB-1: A potential epigenetic regulator in breast cancer metastasis. / Batham, Jacob; Lim, Pek Siew; Rao, Sudha.

In: Cancers, Vol. 11, No. 8, 1143, 09.08.2019, p. 1-20.

Research output: Contribution to journalReview article

TY - JOUR

T1 - SETDB-1: A potential epigenetic regulator in breast cancer metastasis

AU - Batham, Jacob

AU - Lim, Pek Siew

AU - Rao, Sudha

PY - 2019/8/9

Y1 - 2019/8/9

N2 - The full epigenetic repertoire governing breast cancer metastasis is not completely understood. Here, we discuss the histone methyltransferase SET Domain Bifurcated Histone Lysine Methyltransferase 1 (SETDB1) and its role in breast cancer metastasis. SETDB1 serves as an exemplar of the difficulties faced when developing therapies that not only specifically target cancer cells but also the more elusive and aggressive stem cells that contribute to metastasis via epithelialto-mesenchymal transition and confer resistance to therapies.

AB - The full epigenetic repertoire governing breast cancer metastasis is not completely understood. Here, we discuss the histone methyltransferase SET Domain Bifurcated Histone Lysine Methyltransferase 1 (SETDB1) and its role in breast cancer metastasis. SETDB1 serves as an exemplar of the difficulties faced when developing therapies that not only specifically target cancer cells but also the more elusive and aggressive stem cells that contribute to metastasis via epithelialto-mesenchymal transition and confer resistance to therapies.

KW - Breast cancer

KW - Cancer stem cells

KW - Epigenetics

KW - Recurrence

KW - Resistance

KW - SETDB1

KW - Therapy

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DO - 10.3390/cancers11081143

M3 - Review article

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SP - 1

EP - 20

JO - Cancers

JF - Cancers

SN - 2072-6694

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