SETDB-1: A potential epigenetic regulator in breast cancer metastasis

Jacob Batham; Pek Siew Lim; Sudha Rao

doi:10.3390/cancers11081143

SETDB-1: A potential epigenetic regulator in breast cancer metastasis

Jacob Batham, Pek Siew Lim, Sudha Rao

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

69 Downloads (Pure)

Abstract

The full epigenetic repertoire governing breast cancer metastasis is not completely understood. Here, we discuss the histone methyltransferase SET Domain Bifurcated Histone Lysine Methyltransferase 1 (SETDB1) and its role in breast cancer metastasis. SETDB1 serves as an exemplar of the difficulties faced when developing therapies that not only specifically target cancer cells but also the more elusive and aggressive stem cells that contribute to metastasis via epithelialto-mesenchymal transition and confer resistance to therapies.

Original language	English
Article number	1143
Pages (from-to)	1-20
Number of pages	20
Journal	Cancers
Volume	11
Issue number	8
DOIs	https://doi.org/10.3390/cancers11081143
Publication status	Published - 9 Aug 2019

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.3390/cancers11081143Licence: CC BY

ArticleFinal published version, 5.23 MBLicence: CC BY

Cite this

@article{8e0b964442e540098f87539b4297b410,

title = "SETDB-1: A potential epigenetic regulator in breast cancer metastasis",

abstract = "The full epigenetic repertoire governing breast cancer metastasis is not completely understood. Here, we discuss the histone methyltransferase SET Domain Bifurcated Histone Lysine Methyltransferase 1 (SETDB1) and its role in breast cancer metastasis. SETDB1 serves as an exemplar of the difficulties faced when developing therapies that not only specifically target cancer cells but also the more elusive and aggressive stem cells that contribute to metastasis via epithelialto-mesenchymal transition and confer resistance to therapies.",

keywords = "Breast cancer, Cancer stem cells, Epigenetics, Recurrence, Resistance, SETDB1, Therapy",

author = "Jacob Batham and Lim, {Pek Siew} and Sudha Rao",

year = "2019",

month = aug,

day = "9",

doi = "10.3390/cancers11081143",

language = "English",

volume = "11",

pages = "1--20",

journal = "Cancers",

issn = "2072-6694",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "8",

}

TY - JOUR

T1 - SETDB-1: A potential epigenetic regulator in breast cancer metastasis

AU - Batham, Jacob

AU - Lim, Pek Siew

AU - Rao, Sudha

PY - 2019/8/9

Y1 - 2019/8/9

N2 - The full epigenetic repertoire governing breast cancer metastasis is not completely understood. Here, we discuss the histone methyltransferase SET Domain Bifurcated Histone Lysine Methyltransferase 1 (SETDB1) and its role in breast cancer metastasis. SETDB1 serves as an exemplar of the difficulties faced when developing therapies that not only specifically target cancer cells but also the more elusive and aggressive stem cells that contribute to metastasis via epithelialto-mesenchymal transition and confer resistance to therapies.

AB - The full epigenetic repertoire governing breast cancer metastasis is not completely understood. Here, we discuss the histone methyltransferase SET Domain Bifurcated Histone Lysine Methyltransferase 1 (SETDB1) and its role in breast cancer metastasis. SETDB1 serves as an exemplar of the difficulties faced when developing therapies that not only specifically target cancer cells but also the more elusive and aggressive stem cells that contribute to metastasis via epithelialto-mesenchymal transition and confer resistance to therapies.

KW - Breast cancer

KW - Cancer stem cells

KW - Epigenetics

KW - Recurrence

KW - Resistance

KW - SETDB1

KW - Therapy

UR - http://www.scopus.com/inward/record.url?scp=85071609542&partnerID=8YFLogxK

UR - http://www.mendeley.com/research/setdb1-potential-epigenetic-regulator-breast-cancer-metastasis

U2 - 10.3390/cancers11081143

DO - 10.3390/cancers11081143

M3 - Article

AN - SCOPUS:85071609542

SN - 2072-6694

VL - 11

SP - 1

EP - 20

JO - Cancers

JF - Cancers

IS - 8

M1 - 1143

ER -

SETDB-1: A potential epigenetic regulator in breast cancer metastasis

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this