Short-term hematological effects upon completion of a four-week simulated altitude camp

Torben Pottgiesser, Laura A. Garvican, David T. Martin, Jesse M. Featonby, Christopher J. Gore, Yorck O. Schumacher

Research output: Contribution to journalReview article

16 Citations (Scopus)

Abstract

Hemoglobin mass (tHb) is considered to be a main factor for sea-level performance after "live high-train low" (LHTL) altitude training, but little research has focused on the persistence of tHb following cessation of altitude exposure. The aim of the case study was to investigate short-term effects of various hematological measures including tHb upon completion of a simulated altitude camp. Five female cyclists spent 26 nights at simulated altitude (LHTL, 16.6 ± 0.4 h/d, 3000 m in an altitude house) where tHb was measured at baseline, at cessation of the camp, and 9 d thereafter. Venous blood measures (hemoglobin concentration, hematocrit, %reticulocytes, serum erythropoietin, ferritin, lactate dehydrogenase, and haptoglobin) were determined at baseline; on day 21 during LHTL; and at days 2, 5, and 9 after LHTL. Hemoglobin mass increased by 5.5% (90% confidence limits [CL] 2.5 to 8.5%, very likely) after the LHTL training camp. At day 9 after simulated LHTL, tHb decreased by 3.0% (90%CL -5.1 to -1.0%, likely). There was a substantial decrease in serum EPO (-34%, 90%CL -50 to -12%) at 2 d after return to sea level and a rise in ferritin (23%, 90%CL 3 to 46%) coupled with a decrease in %reticulocytes (-23%, 90%CL -34 to -9%) between day 5 and 9 after LHTL. Our findings show that following a hypoxic intervention with a beneficial tHb outcome, there may be a high probability of a rapid tHb decrease upon return to normoxic conditions. This highlights a rapid component in red-cell control and may have implications for the appropriate timing of altitude training in relation to competition.

Original languageEnglish
Pages (from-to)79-83
Number of pages5
JournalInternational Journal of Sports Physiology and Performance
Volume7
Issue number1
Publication statusPublished - 2012
Externally publishedYes

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Hemoglobins
Reticulocytes
Ferritins
Oceans and Seas
Haptoglobins
Erythropoietin
Serum
Hematocrit
L-Lactate Dehydrogenase
Research

Cite this

Pottgiesser, T., Garvican, L. A., Martin, D. T., Featonby, J. M., Gore, C. J., & Schumacher, Y. O. (2012). Short-term hematological effects upon completion of a four-week simulated altitude camp. International Journal of Sports Physiology and Performance, 7(1), 79-83.
Pottgiesser, Torben ; Garvican, Laura A. ; Martin, David T. ; Featonby, Jesse M. ; Gore, Christopher J. ; Schumacher, Yorck O. / Short-term hematological effects upon completion of a four-week simulated altitude camp. In: International Journal of Sports Physiology and Performance. 2012 ; Vol. 7, No. 1. pp. 79-83.
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abstract = "Hemoglobin mass (tHb) is considered to be a main factor for sea-level performance after {"}live high-train low{"} (LHTL) altitude training, but little research has focused on the persistence of tHb following cessation of altitude exposure. The aim of the case study was to investigate short-term effects of various hematological measures including tHb upon completion of a simulated altitude camp. Five female cyclists spent 26 nights at simulated altitude (LHTL, 16.6 ± 0.4 h/d, 3000 m in an altitude house) where tHb was measured at baseline, at cessation of the camp, and 9 d thereafter. Venous blood measures (hemoglobin concentration, hematocrit, {\%}reticulocytes, serum erythropoietin, ferritin, lactate dehydrogenase, and haptoglobin) were determined at baseline; on day 21 during LHTL; and at days 2, 5, and 9 after LHTL. Hemoglobin mass increased by 5.5{\%} (90{\%} confidence limits [CL] 2.5 to 8.5{\%}, very likely) after the LHTL training camp. At day 9 after simulated LHTL, tHb decreased by 3.0{\%} (90{\%}CL -5.1 to -1.0{\%}, likely). There was a substantial decrease in serum EPO (-34{\%}, 90{\%}CL -50 to -12{\%}) at 2 d after return to sea level and a rise in ferritin (23{\%}, 90{\%}CL 3 to 46{\%}) coupled with a decrease in {\%}reticulocytes (-23{\%}, 90{\%}CL -34 to -9{\%}) between day 5 and 9 after LHTL. Our findings show that following a hypoxic intervention with a beneficial tHb outcome, there may be a high probability of a rapid tHb decrease upon return to normoxic conditions. This highlights a rapid component in red-cell control and may have implications for the appropriate timing of altitude training in relation to competition.",
keywords = "Erythropoiesis, Erythropoietin, Hemoglobin, Hypoxia",
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Pottgiesser, T, Garvican, LA, Martin, DT, Featonby, JM, Gore, CJ & Schumacher, YO 2012, 'Short-term hematological effects upon completion of a four-week simulated altitude camp', International Journal of Sports Physiology and Performance, vol. 7, no. 1, pp. 79-83.

Short-term hematological effects upon completion of a four-week simulated altitude camp. / Pottgiesser, Torben; Garvican, Laura A.; Martin, David T.; Featonby, Jesse M.; Gore, Christopher J.; Schumacher, Yorck O.

In: International Journal of Sports Physiology and Performance, Vol. 7, No. 1, 2012, p. 79-83.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Short-term hematological effects upon completion of a four-week simulated altitude camp

AU - Pottgiesser, Torben

AU - Garvican, Laura A.

AU - Martin, David T.

AU - Featonby, Jesse M.

AU - Gore, Christopher J.

AU - Schumacher, Yorck O.

PY - 2012

Y1 - 2012

N2 - Hemoglobin mass (tHb) is considered to be a main factor for sea-level performance after "live high-train low" (LHTL) altitude training, but little research has focused on the persistence of tHb following cessation of altitude exposure. The aim of the case study was to investigate short-term effects of various hematological measures including tHb upon completion of a simulated altitude camp. Five female cyclists spent 26 nights at simulated altitude (LHTL, 16.6 ± 0.4 h/d, 3000 m in an altitude house) where tHb was measured at baseline, at cessation of the camp, and 9 d thereafter. Venous blood measures (hemoglobin concentration, hematocrit, %reticulocytes, serum erythropoietin, ferritin, lactate dehydrogenase, and haptoglobin) were determined at baseline; on day 21 during LHTL; and at days 2, 5, and 9 after LHTL. Hemoglobin mass increased by 5.5% (90% confidence limits [CL] 2.5 to 8.5%, very likely) after the LHTL training camp. At day 9 after simulated LHTL, tHb decreased by 3.0% (90%CL -5.1 to -1.0%, likely). There was a substantial decrease in serum EPO (-34%, 90%CL -50 to -12%) at 2 d after return to sea level and a rise in ferritin (23%, 90%CL 3 to 46%) coupled with a decrease in %reticulocytes (-23%, 90%CL -34 to -9%) between day 5 and 9 after LHTL. Our findings show that following a hypoxic intervention with a beneficial tHb outcome, there may be a high probability of a rapid tHb decrease upon return to normoxic conditions. This highlights a rapid component in red-cell control and may have implications for the appropriate timing of altitude training in relation to competition.

AB - Hemoglobin mass (tHb) is considered to be a main factor for sea-level performance after "live high-train low" (LHTL) altitude training, but little research has focused on the persistence of tHb following cessation of altitude exposure. The aim of the case study was to investigate short-term effects of various hematological measures including tHb upon completion of a simulated altitude camp. Five female cyclists spent 26 nights at simulated altitude (LHTL, 16.6 ± 0.4 h/d, 3000 m in an altitude house) where tHb was measured at baseline, at cessation of the camp, and 9 d thereafter. Venous blood measures (hemoglobin concentration, hematocrit, %reticulocytes, serum erythropoietin, ferritin, lactate dehydrogenase, and haptoglobin) were determined at baseline; on day 21 during LHTL; and at days 2, 5, and 9 after LHTL. Hemoglobin mass increased by 5.5% (90% confidence limits [CL] 2.5 to 8.5%, very likely) after the LHTL training camp. At day 9 after simulated LHTL, tHb decreased by 3.0% (90%CL -5.1 to -1.0%, likely). There was a substantial decrease in serum EPO (-34%, 90%CL -50 to -12%) at 2 d after return to sea level and a rise in ferritin (23%, 90%CL 3 to 46%) coupled with a decrease in %reticulocytes (-23%, 90%CL -34 to -9%) between day 5 and 9 after LHTL. Our findings show that following a hypoxic intervention with a beneficial tHb outcome, there may be a high probability of a rapid tHb decrease upon return to normoxic conditions. This highlights a rapid component in red-cell control and may have implications for the appropriate timing of altitude training in relation to competition.

KW - Erythropoiesis

KW - Erythropoietin

KW - Hemoglobin

KW - Hypoxia

UR - http://www.scopus.com/inward/record.url?scp=84859467416&partnerID=8YFLogxK

M3 - Review article

VL - 7

SP - 79

EP - 83

JO - International Journal of Sports Physiology and Performance

JF - International Journal of Sports Physiology and Performance

SN - 1555-0265

IS - 1

ER -