Signaling to the epigenome

New insights into the roles of nuclear signaling kinases in the context of the immune system and cancer

Pek Siew Lim, Kum Kum Khanna, Sudha Rao

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Abstract

Transcriptional programs initiated by different external cues are tightly regulated by highly conserved signaling kinases. Though the action of signaling kinases is predominantly reported in the cytoplasm, emerging studies describe that their physiological and pathological functions are mediated through direct regulation of gene expression programs. The dual role of signaling kinases to regulate gene transcription occurs via cytoplasmic signaling to the nucleus, wherein they need to enter the nucleus to act as a novel class of epigenetic enzymes that directly tether to the chromatin template and exquisitely (or dynamically) regulate the epigenome.
Original languageEnglish
Article number980
Pages (from-to)1-2
Number of pages2
JournalFrontiers in Immunology
Volume8
DOIs
Publication statusPublished - 21 Aug 2017

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Immune System
Phosphotransferases
Neoplasms
Gene Expression Regulation
Epigenomics
Chromatin
Cues
Cytoplasm
Enzymes
Genes

Cite this

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title = "Signaling to the epigenome: New insights into the roles of nuclear signaling kinases in the context of the immune system and cancer",
abstract = "Transcriptional programs initiated by different external cues are tightly regulated by highly conserved signaling kinases. Though the action of signaling kinases is predominantly reported in the cytoplasm, emerging studies describe that their physiological and pathological functions are mediated through direct regulation of gene expression programs. The dual role of signaling kinases to regulate gene transcription occurs via cytoplasmic signaling to the nucleus, wherein they need to enter the nucleus to act as a novel class of epigenetic enzymes that directly tether to the chromatin template and exquisitely (or dynamically) regulate the epigenome.",
keywords = "Cancer, Epigenetic regulation, Epigenome, Immune system, PKC, Signaling kinase, T cell, Transcription",
author = "Lim, {Pek Siew} and Khanna, {Kum Kum} and Sudha Rao",
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T2 - New insights into the roles of nuclear signaling kinases in the context of the immune system and cancer

AU - Lim, Pek Siew

AU - Khanna, Kum Kum

AU - Rao, Sudha

PY - 2017/8/21

Y1 - 2017/8/21

N2 - Transcriptional programs initiated by different external cues are tightly regulated by highly conserved signaling kinases. Though the action of signaling kinases is predominantly reported in the cytoplasm, emerging studies describe that their physiological and pathological functions are mediated through direct regulation of gene expression programs. The dual role of signaling kinases to regulate gene transcription occurs via cytoplasmic signaling to the nucleus, wherein they need to enter the nucleus to act as a novel class of epigenetic enzymes that directly tether to the chromatin template and exquisitely (or dynamically) regulate the epigenome.

AB - Transcriptional programs initiated by different external cues are tightly regulated by highly conserved signaling kinases. Though the action of signaling kinases is predominantly reported in the cytoplasm, emerging studies describe that their physiological and pathological functions are mediated through direct regulation of gene expression programs. The dual role of signaling kinases to regulate gene transcription occurs via cytoplasmic signaling to the nucleus, wherein they need to enter the nucleus to act as a novel class of epigenetic enzymes that directly tether to the chromatin template and exquisitely (or dynamically) regulate the epigenome.

KW - Cancer

KW - Epigenetic regulation

KW - Epigenome

KW - Immune system

KW - PKC

KW - Signaling kinase

KW - T cell

KW - Transcription

UR - http://www.scopus.com/inward/record.url?scp=85028019892&partnerID=8YFLogxK

UR - http://www.mendeley.com/research/signaling-epigenome-new-insights-roles-nuclear-signaling-kinases-context-immune-system-cancer

U2 - 10.3389/fimmu.2017.00980

DO - 10.3389/fimmu.2017.00980

M3 - Editorial

VL - 8

SP - 1

EP - 2

JO - Frontiers in Immunology

JF - Frontiers in Immunology

SN - 1664-3224

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ER -