Single Tablet Regimen Usage and Efficacy in the Treatment of HIV Infection in Australia

B. Armstrong, D. Chan, J. Stewart, Damien Fagan, D. Smith

Research output: Contribution to journalArticle

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Abstract

Single tablet regimens (STRs) for HIV infection improve patient satisfaction, quality of life, medication adherence, and virological suppression compared to multitablet regimens (MTRs). This is the first study assessing STR uptake and durability in Australia. This retrospective audit of all patients receiving an STR (?? = 299) at a large Sydney HIV clinic (January 2012–December 2013) assessed patient demographics, treatment prior to STR, HIV RNA load and D4 during MTR and STR dosing, and reasons for STR switch. 206 patients switched fromprevious antiretroviral treatment to an STR, of which 88% switched froman MTR. Reasons for switching included desire to simplify treatment (57%), reduced side effects or toxicity (18%), and cost-saving for the patient. There was no switching for virological failure. Compared to when on an MTR, patients switching to an STR had significantly lower HIV RNA counts (?? <0.001) and significantly higher CD4 counts (?? <0.001). The discontinuation rate from STR was very low and all patients who switched to an STR maintained virological suppression throughout the study duration, although the study is limited by the absence of a control group.
Original languageEnglish
Article number570316
Pages (from-to)1-5
Number of pages5
JournalAIDS Research and Treatment
Volume2015
DOIs
Publication statusPublished - 2015

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Tablets
HIV Infections
HIV
RNA
Medication Adherence
CD4 Lymphocyte Count
Patient Satisfaction
Therapeutics
Quality of Life
Demography
Costs and Cost Analysis
Control Groups

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Armstrong, B. ; Chan, D. ; Stewart, J. ; Fagan, Damien ; Smith, D. / Single Tablet Regimen Usage and Efficacy in the Treatment of HIV Infection in Australia. In: AIDS Research and Treatment. 2015 ; Vol. 2015. pp. 1-5.
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abstract = "Single tablet regimens (STRs) for HIV infection improve patient satisfaction, quality of life, medication adherence, and virological suppression compared to multitablet regimens (MTRs). This is the first study assessing STR uptake and durability in Australia. This retrospective audit of all patients receiving an STR (?? = 299) at a large Sydney HIV clinic (January 2012–December 2013) assessed patient demographics, treatment prior to STR, HIV RNA load and D4 during MTR and STR dosing, and reasons for STR switch. 206 patients switched fromprevious antiretroviral treatment to an STR, of which 88{\%} switched froman MTR. Reasons for switching included desire to simplify treatment (57{\%}), reduced side effects or toxicity (18{\%}), and cost-saving for the patient. There was no switching for virological failure. Compared to when on an MTR, patients switching to an STR had significantly lower HIV RNA counts (?? <0.001) and significantly higher CD4 counts (?? <0.001). The discontinuation rate from STR was very low and all patients who switched to an STR maintained virological suppression throughout the study duration, although the study is limited by the absence of a control group.",
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Single Tablet Regimen Usage and Efficacy in the Treatment of HIV Infection in Australia. / Armstrong, B.; Chan, D.; Stewart, J.; Fagan, Damien; Smith, D.

In: AIDS Research and Treatment, Vol. 2015, 570316, 2015, p. 1-5.

Research output: Contribution to journalArticle

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AB - Single tablet regimens (STRs) for HIV infection improve patient satisfaction, quality of life, medication adherence, and virological suppression compared to multitablet regimens (MTRs). This is the first study assessing STR uptake and durability in Australia. This retrospective audit of all patients receiving an STR (?? = 299) at a large Sydney HIV clinic (January 2012–December 2013) assessed patient demographics, treatment prior to STR, HIV RNA load and D4 during MTR and STR dosing, and reasons for STR switch. 206 patients switched fromprevious antiretroviral treatment to an STR, of which 88% switched froman MTR. Reasons for switching included desire to simplify treatment (57%), reduced side effects or toxicity (18%), and cost-saving for the patient. There was no switching for virological failure. Compared to when on an MTR, patients switching to an STR had significantly lower HIV RNA counts (?? <0.001) and significantly higher CD4 counts (?? <0.001). The discontinuation rate from STR was very low and all patients who switched to an STR maintained virological suppression throughout the study duration, although the study is limited by the absence of a control group.

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