Single-walled carbon nanotube-based polymer monoliths for the enantioselective nano-liquid chromatographic separation of racemic pharmaceuticals

Marwa Ahmed, Mir Aghili Yajadda, Zhao Han, Dawei Su, Guoxiu Wang, Kostya Ostrikov, Ashraf GHANEM

    Research output: Contribution to journalArticle

    32 Citations (Scopus)

    Abstract

    Single-walled carbon nanotubes were encapsulated into different polymer-based monolithic backbones. The polymer monoliths were prepared via the copolymerization of 20% monomers, glycidyl methacrylate, 20% ethylene glycol dimethacrylate and 60% porogens (36% 1-propanol, 18% 1,4-butanediol) or 16.4% monomers (16% butyl methacrylate, 0.4% sulfopropyl methacrylate), 23.6% ethylene glycol dimethacrylate and 60% porogens (36% 1-propanol, 18% 1,4-butanediol) along with 6% single-walled carbon nanotubes aqueous suspension. The effect of single-walled carbon nanotubes on the chiral separation of twelve classes of pharmaceutical racemates namely; α- and β-blockers, antiinflammatory drugs, antifungal drugs, dopamine antagonists, norepinephrine-dopamine reuptake inhibitors, catecholamines, sedative hypnotics, diuretics, antihistaminics, anticancer drugs and antiarrhythmic drugs was investigated. The enantioselective separation was carried out under multimodal elution to explore the chiral recognition capabilities of single-walled carbon nanotubes using reversed phase, polar organic and normal phase chromatographic conditions using nano-liquid chromatography. Baseline separation was achieved for celiprolol, chlorpheniramine, etozoline, nomifensine and sulconazole under multimodal elution conditions. Satisfactory repeatability was achieved through run-to-run, column-to-column and batch-to-batch investigations. Our findings demonstrate that single-walled carbon nanotubes represent a promising stationary phase for the chiral separation and may open the field for a new class of chiral selectors.

    Original languageEnglish
    Pages (from-to)100-109
    Number of pages10
    JournalJournal of Chromatography A
    Volume1360
    DOIs
    Publication statusPublished - 2014

    Fingerprint

    Carbon Nanotubes
    Single-walled carbon nanotubes (SWCN)
    Polymers
    Liquids
    1-Propanol
    Pharmaceutical Preparations
    Celiprolol
    Monomers
    Dopamine Uptake Inhibitors
    Nomifensine
    Chlorpheniramine
    Dopamine Antagonists
    Methacrylates
    Anti-Arrhythmia Agents
    Liquid chromatography
    Hypnotics and Sedatives
    Diuretics
    Liquid Chromatography
    Copolymerization
    Catecholamines

    Cite this

    Ahmed, Marwa ; Aghili Yajadda, Mir ; Han, Zhao ; Su, Dawei ; Wang, Guoxiu ; Ostrikov, Kostya ; GHANEM, Ashraf. / Single-walled carbon nanotube-based polymer monoliths for the enantioselective nano-liquid chromatographic separation of racemic pharmaceuticals. In: Journal of Chromatography A. 2014 ; Vol. 1360. pp. 100-109.
    @article{a0dcc13cda9242d2a49883f075c78cc5,
    title = "Single-walled carbon nanotube-based polymer monoliths for the enantioselective nano-liquid chromatographic separation of racemic pharmaceuticals",
    abstract = "Single-walled carbon nanotubes were encapsulated into different polymer-based monolithic backbones. The polymer monoliths were prepared via the copolymerization of 20{\%} monomers, glycidyl methacrylate, 20{\%} ethylene glycol dimethacrylate and 60{\%} porogens (36{\%} 1-propanol, 18{\%} 1,4-butanediol) or 16.4{\%} monomers (16{\%} butyl methacrylate, 0.4{\%} sulfopropyl methacrylate), 23.6{\%} ethylene glycol dimethacrylate and 60{\%} porogens (36{\%} 1-propanol, 18{\%} 1,4-butanediol) along with 6{\%} single-walled carbon nanotubes aqueous suspension. The effect of single-walled carbon nanotubes on the chiral separation of twelve classes of pharmaceutical racemates namely; α- and β-blockers, antiinflammatory drugs, antifungal drugs, dopamine antagonists, norepinephrine-dopamine reuptake inhibitors, catecholamines, sedative hypnotics, diuretics, antihistaminics, anticancer drugs and antiarrhythmic drugs was investigated. The enantioselective separation was carried out under multimodal elution to explore the chiral recognition capabilities of single-walled carbon nanotubes using reversed phase, polar organic and normal phase chromatographic conditions using nano-liquid chromatography. Baseline separation was achieved for celiprolol, chlorpheniramine, etozoline, nomifensine and sulconazole under multimodal elution conditions. Satisfactory repeatability was achieved through run-to-run, column-to-column and batch-to-batch investigations. Our findings demonstrate that single-walled carbon nanotubes represent a promising stationary phase for the chiral separation and may open the field for a new class of chiral selectors.",
    keywords = "Single--walled-carbon-nanotubes, Polymer-monolith, Chiral-separation, Nano-LC, Reversed-phase-chromatography, Polar organic chromatography, Reversed phase chromatography, Chiral separation, Polymer monolith, Single-walled carbon nanotubes",
    author = "Marwa Ahmed and {Aghili Yajadda}, Mir and Zhao Han and Dawei Su and Guoxiu Wang and Kostya Ostrikov and Ashraf GHANEM",
    year = "2014",
    doi = "10.1016/j.chroma.2014.07.052",
    language = "English",
    volume = "1360",
    pages = "100--109",
    journal = "Journal of Chromatography",
    issn = "0021-9673",
    publisher = "Elsevier",

    }

    Single-walled carbon nanotube-based polymer monoliths for the enantioselective nano-liquid chromatographic separation of racemic pharmaceuticals. / Ahmed, Marwa; Aghili Yajadda, Mir; Han, Zhao; Su, Dawei; Wang, Guoxiu; Ostrikov, Kostya; GHANEM, Ashraf.

    In: Journal of Chromatography A, Vol. 1360, 2014, p. 100-109.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Single-walled carbon nanotube-based polymer monoliths for the enantioselective nano-liquid chromatographic separation of racemic pharmaceuticals

    AU - Ahmed, Marwa

    AU - Aghili Yajadda, Mir

    AU - Han, Zhao

    AU - Su, Dawei

    AU - Wang, Guoxiu

    AU - Ostrikov, Kostya

    AU - GHANEM, Ashraf

    PY - 2014

    Y1 - 2014

    N2 - Single-walled carbon nanotubes were encapsulated into different polymer-based monolithic backbones. The polymer monoliths were prepared via the copolymerization of 20% monomers, glycidyl methacrylate, 20% ethylene glycol dimethacrylate and 60% porogens (36% 1-propanol, 18% 1,4-butanediol) or 16.4% monomers (16% butyl methacrylate, 0.4% sulfopropyl methacrylate), 23.6% ethylene glycol dimethacrylate and 60% porogens (36% 1-propanol, 18% 1,4-butanediol) along with 6% single-walled carbon nanotubes aqueous suspension. The effect of single-walled carbon nanotubes on the chiral separation of twelve classes of pharmaceutical racemates namely; α- and β-blockers, antiinflammatory drugs, antifungal drugs, dopamine antagonists, norepinephrine-dopamine reuptake inhibitors, catecholamines, sedative hypnotics, diuretics, antihistaminics, anticancer drugs and antiarrhythmic drugs was investigated. The enantioselective separation was carried out under multimodal elution to explore the chiral recognition capabilities of single-walled carbon nanotubes using reversed phase, polar organic and normal phase chromatographic conditions using nano-liquid chromatography. Baseline separation was achieved for celiprolol, chlorpheniramine, etozoline, nomifensine and sulconazole under multimodal elution conditions. Satisfactory repeatability was achieved through run-to-run, column-to-column and batch-to-batch investigations. Our findings demonstrate that single-walled carbon nanotubes represent a promising stationary phase for the chiral separation and may open the field for a new class of chiral selectors.

    AB - Single-walled carbon nanotubes were encapsulated into different polymer-based monolithic backbones. The polymer monoliths were prepared via the copolymerization of 20% monomers, glycidyl methacrylate, 20% ethylene glycol dimethacrylate and 60% porogens (36% 1-propanol, 18% 1,4-butanediol) or 16.4% monomers (16% butyl methacrylate, 0.4% sulfopropyl methacrylate), 23.6% ethylene glycol dimethacrylate and 60% porogens (36% 1-propanol, 18% 1,4-butanediol) along with 6% single-walled carbon nanotubes aqueous suspension. The effect of single-walled carbon nanotubes on the chiral separation of twelve classes of pharmaceutical racemates namely; α- and β-blockers, antiinflammatory drugs, antifungal drugs, dopamine antagonists, norepinephrine-dopamine reuptake inhibitors, catecholamines, sedative hypnotics, diuretics, antihistaminics, anticancer drugs and antiarrhythmic drugs was investigated. The enantioselective separation was carried out under multimodal elution to explore the chiral recognition capabilities of single-walled carbon nanotubes using reversed phase, polar organic and normal phase chromatographic conditions using nano-liquid chromatography. Baseline separation was achieved for celiprolol, chlorpheniramine, etozoline, nomifensine and sulconazole under multimodal elution conditions. Satisfactory repeatability was achieved through run-to-run, column-to-column and batch-to-batch investigations. Our findings demonstrate that single-walled carbon nanotubes represent a promising stationary phase for the chiral separation and may open the field for a new class of chiral selectors.

    KW - Single--walled-carbon-nanotubes

    KW - Polymer-monolith

    KW - Chiral-separation

    KW - Nano-LC

    KW - Reversed-phase-chromatography

    KW - Polar organic chromatography

    KW - Reversed phase chromatography

    KW - Chiral separation

    KW - Polymer monolith

    KW - Single-walled carbon nanotubes

    UR - http://www.scopus.com/inward/record.url?scp=84906783022&partnerID=8YFLogxK

    UR - http://www.mendeley.com/research/singlewalled-carbon-nanotubebased-polymer-monoliths-enantioselective-nanoliquid-chromatographic-sepa

    U2 - 10.1016/j.chroma.2014.07.052

    DO - 10.1016/j.chroma.2014.07.052

    M3 - Article

    VL - 1360

    SP - 100

    EP - 109

    JO - Journal of Chromatography

    JF - Journal of Chromatography

    SN - 0021-9673

    ER -