Small Non-coding RNA Expression Following Respiratory Syncytial Virus or Measles Virus Infection of Neuronal Cells

Abhijeet A. Bakre, Catherine Duffy, Hani’ah Abdullah, S. Louise Cosby, Ralph A. Tripp

Research output: Contribution to journalArticlepeer-review

Abstract

Respiratory syncytial virus (RSV) or measles virus (MeV) infection modifies host responses through small non-coding RNA (sncRNA) expression. We show that RSV or MeV infection of neuronal cells induces sncRNAs including various microRNAs and transfer RNA fragments (tRFs). We show that these tRFs originate from select tRNAs (GCC and CAC for glycine, CTT and AAC for Valine, and CCC and TTT for Lysine). Some of the tRNAs are rarely used by RSV or MeV as indicated by relative synonymous codon usage indices suggesting selective cleavage of the tRNAs occurs in infected neuronal cells. The data implies that differentially expressed sncRNAs may regulate host gene expression via multiple mechanisms in neuronal cells.

Original languageEnglish
Article number671852
Pages (from-to)1-11
Number of pages11
JournalFrontiers in Microbiology
Volume12
DOIs
Publication statusPublished - 3 Sep 2021
Externally publishedYes

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