Status of Blood Levels of Superoxide Dismutase in Patients with Malaria: A Systematic Review and Meta-Analysis

Kwuntida Uthaisar Kotepui; Onchuma Mueangson; Wanida Mala; Aongart Mahittikorn; Kinley Wangdi; Manas Kotepui

doi:10.1089/ars.2023.0273

Status of Blood Levels of Superoxide Dismutase in Patients with Malaria: A Systematic Review and Meta-Analysis

Kwuntida Uthaisar Kotepui
, Onchuma Mueangson
, Wanida Mala
, Aongart Mahittikorn
, Kinley Wangdi
, Manas Kotepui

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Aims: The evidence of superoxide dismutase (SOD) in the pathogenesis of malaria is inconsistent. This study aimed to synthesize the evidence of blood levels of SOD in patients with malaria and determine the association of blood levels of SOD with the severity of malaria. Results: A total of 1874 articles were retrieved from database searches and 28 studies were included in the review. The blood levels of SOD were lower in individuals with malaria compared with those without malaria infection (p < 0.01, Cohen's d: -2.06, 95% CI: -2.99 to -1.14), I ²: 98.96%, 2181 malaria cases/1186 uninfected cases). There were no differences in blood levels of SOD between severe and nonsevere malaria patients (p = 0.09, Cohen's d: -1.57, 95% CI: -3.39 to 0.26), I ²: 96.02%, 69 severe malaria cases/256 nonsevere malaria cases). Innovation and Conclusion: The blood levels of SOD were lower in malaria patients compared with those without malaria infection. Further studies will be required to determine the extent to which SOD might prevent Plasmodium infections during pregnancy. Antioxid. Redox Signal. 40, 222-235.

Original language	English
Pages (from-to)	222-235
Number of pages	14
Journal	Antioxidants and Redox Signaling
Volume	40
Issue number	4-6
DOIs	https://doi.org/10.1089/ars.2023.0273
Publication status	Published - Feb 2024
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

10.1089/ars.2023.0273Licence: Unspecified

Cite this

@article{62c061d4f20d4d5ebed55620f89e1b8e,

title = "Status of Blood Levels of Superoxide Dismutase in Patients with Malaria: A Systematic Review and Meta-Analysis",

abstract = "Aims: The evidence of superoxide dismutase (SOD) in the pathogenesis of malaria is inconsistent. This study aimed to synthesize the evidence of blood levels of SOD in patients with malaria and determine the association of blood levels of SOD with the severity of malaria. Results: A total of 1874 articles were retrieved from database searches and 28 studies were included in the review. The blood levels of SOD were lower in individuals with malaria compared with those without malaria infection (p < 0.01, Cohen's d: -2.06, 95\% CI: -2.99 to -1.14), I 2: 98.96\%, 2181 malaria cases/1186 uninfected cases). There were no differences in blood levels of SOD between severe and nonsevere malaria patients (p = 0.09, Cohen's d: -1.57, 95\% CI: -3.39 to 0.26), I 2: 96.02\%, 69 severe malaria cases/256 nonsevere malaria cases). Innovation and Conclusion: The blood levels of SOD were lower in malaria patients compared with those without malaria infection. Further studies will be required to determine the extent to which SOD might prevent Plasmodium infections during pregnancy. Antioxid. Redox Signal. 40, 222-235.",

keywords = "Pregnancy, Female, Humans, Superoxide Dismutase, Malaria, meta-analysis, SOD, malaria, systematic review, Plasmodium, marker, superoxide dismutase, complicated, severe",

author = "Kotepui, \{Kwuntida Uthaisar\} and Onchuma Mueangson and Wanida Mala and Aongart Mahittikorn and Kinley Wangdi and Manas Kotepui",

note = "Funding Information: This study did not receive any funding. K.W. is funded by Australian National Health and Medical Research Council (NHMRC) Investigator Grant (2008697). Publisher Copyright: {\textcopyright} 2024 Mary Ann Liebert Inc.. All rights reserved.",

year = "2024",

month = feb,

doi = "10.1089/ars.2023.0273",

language = "English",

volume = "40",

pages = "222--235",

journal = "Antioxidants and Redox Signaling",

issn = "1523-0864",

publisher = "Mary Ann Liebert Inc",

number = "4-6",

}

TY - JOUR

T1 - Status of Blood Levels of Superoxide Dismutase in Patients with Malaria

T2 - A Systematic Review and Meta-Analysis

AU - Kotepui, Kwuntida Uthaisar

AU - Mueangson, Onchuma

AU - Mala, Wanida

AU - Mahittikorn, Aongart

AU - Wangdi, Kinley

AU - Kotepui, Manas

N1 - Funding Information: This study did not receive any funding. K.W. is funded by Australian National Health and Medical Research Council (NHMRC) Investigator Grant (2008697). Publisher Copyright: © 2024 Mary Ann Liebert Inc.. All rights reserved.

PY - 2024/2

Y1 - 2024/2

N2 - Aims: The evidence of superoxide dismutase (SOD) in the pathogenesis of malaria is inconsistent. This study aimed to synthesize the evidence of blood levels of SOD in patients with malaria and determine the association of blood levels of SOD with the severity of malaria. Results: A total of 1874 articles were retrieved from database searches and 28 studies were included in the review. The blood levels of SOD were lower in individuals with malaria compared with those without malaria infection (p < 0.01, Cohen's d: -2.06, 95% CI: -2.99 to -1.14), I 2: 98.96%, 2181 malaria cases/1186 uninfected cases). There were no differences in blood levels of SOD between severe and nonsevere malaria patients (p = 0.09, Cohen's d: -1.57, 95% CI: -3.39 to 0.26), I 2: 96.02%, 69 severe malaria cases/256 nonsevere malaria cases). Innovation and Conclusion: The blood levels of SOD were lower in malaria patients compared with those without malaria infection. Further studies will be required to determine the extent to which SOD might prevent Plasmodium infections during pregnancy. Antioxid. Redox Signal. 40, 222-235.

AB - Aims: The evidence of superoxide dismutase (SOD) in the pathogenesis of malaria is inconsistent. This study aimed to synthesize the evidence of blood levels of SOD in patients with malaria and determine the association of blood levels of SOD with the severity of malaria. Results: A total of 1874 articles were retrieved from database searches and 28 studies were included in the review. The blood levels of SOD were lower in individuals with malaria compared with those without malaria infection (p < 0.01, Cohen's d: -2.06, 95% CI: -2.99 to -1.14), I 2: 98.96%, 2181 malaria cases/1186 uninfected cases). There were no differences in blood levels of SOD between severe and nonsevere malaria patients (p = 0.09, Cohen's d: -1.57, 95% CI: -3.39 to 0.26), I 2: 96.02%, 69 severe malaria cases/256 nonsevere malaria cases). Innovation and Conclusion: The blood levels of SOD were lower in malaria patients compared with those without malaria infection. Further studies will be required to determine the extent to which SOD might prevent Plasmodium infections during pregnancy. Antioxid. Redox Signal. 40, 222-235.

KW - Pregnancy

KW - Female

KW - Humans

KW - Superoxide Dismutase

KW - Malaria

KW - meta-analysis

KW - SOD

KW - malaria

KW - systematic review

KW - Plasmodium

KW - marker

KW - superoxide dismutase

KW - complicated

KW - severe

UR - https://www.scopus.com/pages/publications/85169154898

U2 - 10.1089/ars.2023.0273

DO - 10.1089/ars.2023.0273

M3 - Article

C2 - 37125449

SN - 1523-0864

VL - 40

SP - 222

EP - 235

JO - Antioxidants and Redox Signaling

JF - Antioxidants and Redox Signaling

IS - 4-6

ER -

Status of Blood Levels of Superoxide Dismutase in Patients with Malaria: A Systematic Review and Meta-Analysis

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this