Strict glycemic control and mortality risk among US adults with type 2 diabetes

Evelyn Davila, Hermes Florez, Mary Trepka, Lora Fleming, Theo NIYONSENGA, David J. Lee, Jai Parkash

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Objective
To assess the relationships between strict HbA1c levels and mortality risk among adults with type 2 diabetes by age, insulin therapy, and hypertension comorbidity.

Methods
Data of adult participants with type 2 diabetes from the third National Health and Nutrition Examination Survey (1988–1994) and its linked mortality file (with follow-up death up to 2000) were used.

Results
Having strict glycemic control (i.e., HbA1c ≤6.5%) was associated with a lower risk of mortality (hazards ratio=0.69; 95% confidence interval=0.48–0.98). However, among those with strict glycemic control levels, statistically significant results were not found.

Conclusion
Reaching strict glycemic control levels in the general US population with type 2 diabetes appears to be associated with lower mortality. Further research is needed as to how strict glycemic control affects certain diabetic groups.
Original languageEnglish
Pages (from-to)289-291
Number of pages3
JournalJournal of Diabetes and Its Complications
Volume25
Issue number5
DOIs
Publication statusPublished - 2011
Externally publishedYes

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Type 2 Diabetes Mellitus
Mortality
Nutrition Surveys
Comorbidity
Confidence Intervals
Insulin
Hypertension
Research
Population
Therapeutics

Cite this

Davila, Evelyn ; Florez, Hermes ; Trepka, Mary ; Fleming, Lora ; NIYONSENGA, Theo ; Lee, David J. ; Parkash, Jai. / Strict glycemic control and mortality risk among US adults with type 2 diabetes. In: Journal of Diabetes and Its Complications. 2011 ; Vol. 25, No. 5. pp. 289-291.
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abstract = "ObjectiveTo assess the relationships between strict HbA1c levels and mortality risk among adults with type 2 diabetes by age, insulin therapy, and hypertension comorbidity.MethodsData of adult participants with type 2 diabetes from the third National Health and Nutrition Examination Survey (1988–1994) and its linked mortality file (with follow-up death up to 2000) were used.ResultsHaving strict glycemic control (i.e., HbA1c ≤6.5{\%}) was associated with a lower risk of mortality (hazards ratio=0.69; 95{\%} confidence interval=0.48–0.98). However, among those with strict glycemic control levels, statistically significant results were not found.ConclusionReaching strict glycemic control levels in the general US population with type 2 diabetes appears to be associated with lower mortality. Further research is needed as to how strict glycemic control affects certain diabetic groups.",
author = "Evelyn Davila and Hermes Florez and Mary Trepka and Lora Fleming and Theo NIYONSENGA and Lee, {David J.} and Jai Parkash",
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Strict glycemic control and mortality risk among US adults with type 2 diabetes. / Davila, Evelyn; Florez, Hermes; Trepka, Mary; Fleming, Lora; NIYONSENGA, Theo; Lee, David J.; Parkash, Jai.

In: Journal of Diabetes and Its Complications, Vol. 25, No. 5, 2011, p. 289-291.

Research output: Contribution to journalArticle

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T1 - Strict glycemic control and mortality risk among US adults with type 2 diabetes

AU - Davila, Evelyn

AU - Florez, Hermes

AU - Trepka, Mary

AU - Fleming, Lora

AU - NIYONSENGA, Theo

AU - Lee, David J.

AU - Parkash, Jai

PY - 2011

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N2 - ObjectiveTo assess the relationships between strict HbA1c levels and mortality risk among adults with type 2 diabetes by age, insulin therapy, and hypertension comorbidity.MethodsData of adult participants with type 2 diabetes from the third National Health and Nutrition Examination Survey (1988–1994) and its linked mortality file (with follow-up death up to 2000) were used.ResultsHaving strict glycemic control (i.e., HbA1c ≤6.5%) was associated with a lower risk of mortality (hazards ratio=0.69; 95% confidence interval=0.48–0.98). However, among those with strict glycemic control levels, statistically significant results were not found.ConclusionReaching strict glycemic control levels in the general US population with type 2 diabetes appears to be associated with lower mortality. Further research is needed as to how strict glycemic control affects certain diabetic groups.

AB - ObjectiveTo assess the relationships between strict HbA1c levels and mortality risk among adults with type 2 diabetes by age, insulin therapy, and hypertension comorbidity.MethodsData of adult participants with type 2 diabetes from the third National Health and Nutrition Examination Survey (1988–1994) and its linked mortality file (with follow-up death up to 2000) were used.ResultsHaving strict glycemic control (i.e., HbA1c ≤6.5%) was associated with a lower risk of mortality (hazards ratio=0.69; 95% confidence interval=0.48–0.98). However, among those with strict glycemic control levels, statistically significant results were not found.ConclusionReaching strict glycemic control levels in the general US population with type 2 diabetes appears to be associated with lower mortality. Further research is needed as to how strict glycemic control affects certain diabetic groups.

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