Study Protocol for the DETECTIVE Study

An International Collaborative Study To Develop Consensus Statements for Deferred Treatment with Curative Intent for Localised Prostate Cancer

Thomas B L Lam, Steven MacLennan, Karin Plass, Peter-Paul M Willemse, Malcolm D Mason, Philip Cornford, James Donaldson, Niall F Davis, Paolo Dell'Oglio, Christian Fankhauser, Nikos Grivas, Alexandre Ingels, Michael Lardas, Matthew Liew, Karl H Pang, Catherine Paterson, Muhammad I Omar, Fabio Zattoni, Karel T Buddingh, Thomas Van den Broeck & 20 others Marcus G Cumberbatch, Nicola Fossati, Tobias Gross, Lisa Moris, Ivo G Schoots, Roderick C N van den Bergh, Erik Briers, Stefano Fanti, Maria De Santis, Silke Gillessen, Jeremy P Grummet, Ann M Henry, Henk G van der Poel, Theodorus H van der Kwast, Olivier Rouvière, Derya Tilki, Thomas Wiegel, James N'Dow, Hendrik Van Poppel, Nicolas Mottet

Research output: Contribution to journalLetter

3 Citations (Scopus)


Deferred active treatment (DAT) strategies for men with localised prostate cancer have emerged as a viable alternative to radical intervention as we aim to avoid the consequences of overtreatment. Nevertheless, such strategies remain controversial, with significant uncertainty and heterogeneity in all domains, including criteria for patient selection, the nature and timing of interventions during follow-up, criteria and thresholds for reclassification, and which outcome measures should be prioritised [1], [2], [3]. These are important barriers to the conduct and uptake of DAT by clinicians and patients as they prohibit comparison of the clinical effectiveness of different protocols. In order to address these issues in a comprehensive, robust, and systematic manner, the European Association of Urology (EAU) Prostate Cancer Guidelines Panel, in partnership with other leading guideline authorities and organisations (listed in Appendix A), has commissioned a project to develop consensus statements for all domains relating to DAT to standardise clinical practice and research.
Original languageEnglish
Pages (from-to)1-4
Number of pages4
JournalEuropean Urology
Publication statusE-pub ahead of print - 22 Nov 2018
Externally publishedYes


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