Sub-2 μm Silica Particles in Chiral Separation

Diana IBRAHIM, Ashraf GHANEM

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Abstract

For decades, the race for the shortest chromatogram with the best resolution and separation efficiency has been the focus of researchers and manufacturers. Considerable advancement has been attained in the field of separation science with the widespread application and outstanding performance in nanomaterials. According to the van Deemter equation, sub-2 micron particles employed in conventional HPLC short column should subsequently result in analysis time reduction and efficiency improvements without the drawback of high pressure associated with sub-2 micron particles. This chapter provides comprehensive discussion about the applications of the new sub 2 microns silica particles in chiral separation of racemates.
Original languageEnglish
Title of host publicationNew Uses of Micro and Nanomaterials
EditorsMarcelo Ruben Pagnola, Jairo Useche Vivero, Andres Guillermo Marrugo
Place of PublicationHungary
PublisherIntechOpen
Chapter4
Pages55-72
Number of pages18
ISBN (Print)9781789841749, 9781789841732
DOIs
Publication statusPublished - 10 Oct 2018

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IBRAHIM, D., & GHANEM, A. (2018). Sub-2 μm Silica Particles in Chiral Separation. In M. R. Pagnola, J. U. Vivero, & A. G. Marrugo (Eds.), New Uses of Micro and Nanomaterials (pp. 55-72). Hungary: IntechOpen. https://doi.org/10.5772/intechopen.79063