SU‐GG‐J‐162

Radiosensitization by Gold Nanoparticles in Superficial Radiotherapy Techniques

W. Rahman, N. Bishara, C. He, T. Ackerly, P. Jackson, C. Wong, R. Davidson, M. Geso

Research output: A Conference proceeding or a Chapter in BookConference contribution

1 Citation (Scopus)

Abstract

Purpose: To investigate the radiosensitization of superficial kilovoltage range of x‐ray energy and megavoltage electron beams due to the presence of gold nanoparticles (AuNps) using cell survival curves and normoxic polyacrymide gel (nPAG). Method and Materials: Bovine aortic endothelial cells (BAECs) with and without AuNps were irradiated with kilovoltage superficial x‐ray beams and megavoltage electron beams. Cell survival at various concentrations of AuNps (0.25mMol–1mMol) was measured using colorimetric assay. Level of dose enhancement for x‐ray and electron beams was also quantified using AuNps doped nPAG. Results: AuNps enhanced the cells killing up to 21 fold for 1mMol of AuNps irradiated with 80 kVp x‐ray beams. Maximum dose enhancement factor (DEF) of 4.63 was measured for 12 MeV electron beams in the presence of 1mMol AuNps. 80 kVp which represents effective beam energy of around 40 keV was the optimum energy found that yield highest enhancement ratio. Measurements using AuNps doped nPAG also exhibit higher polymerization resulting from increased photoelectric interactions, Auger electrons and characteristic x‐ray generation. The experimental dose enhancements obtained were also in agreement with theoretical calculation and those previously documented for iodine atoms. Conclusion: Both experiments with cell culture and nPAG confirm that AuNps are able to enhance the radiation dose for x‐ray and electron superficial therapy. Lower doses from external sources are required to produce the same radiation effect with AuNps compared without application of AuNps. This will lead to improvement in superficial radiotherapy techniques of both x‐ray and electron. The use of this technique with microbeam radiotherapy technique and kilovoltage type intraoperative radiotherapy techniques are now under investigation in our group.

Original languageEnglish
Title of host publicationMedical Physics
Pages2716
Number of pages1
Volume35
Edition6
DOIs
Publication statusPublished - Jun 2008
Externally publishedYes

Publication series

NameMedical Physics
PublisherAAPM - American Association of Physicists in Medicine
ISSN (Print)0094-2405

Fingerprint

Gold
Nanoparticles
Radiotherapy
X-Rays
Electrons
Gels
Cell Survival
Radiation Effects
Polymerization
Iodine
Endothelial Cells
Cell Culture Techniques
Radiation

Cite this

Rahman, W., Bishara, N., He, C., Ackerly, T., Jackson, P., Wong, C., ... Geso, M. (2008). SU‐GG‐J‐162: Radiosensitization by Gold Nanoparticles in Superficial Radiotherapy Techniques. In Medical Physics (6 ed., Vol. 35, pp. 2716). (Medical Physics). https://doi.org/10.1118/1.2961711
Rahman, W. ; Bishara, N. ; He, C. ; Ackerly, T. ; Jackson, P. ; Wong, C. ; Davidson, R. ; Geso, M. / SU‐GG‐J‐162 : Radiosensitization by Gold Nanoparticles in Superficial Radiotherapy Techniques. Medical Physics. Vol. 35 6. ed. 2008. pp. 2716 (Medical Physics).
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abstract = "Purpose: To investigate the radiosensitization of superficial kilovoltage range of x‐ray energy and megavoltage electron beams due to the presence of gold nanoparticles (AuNps) using cell survival curves and normoxic polyacrymide gel (nPAG). Method and Materials: Bovine aortic endothelial cells (BAECs) with and without AuNps were irradiated with kilovoltage superficial x‐ray beams and megavoltage electron beams. Cell survival at various concentrations of AuNps (0.25mMol–1mMol) was measured using colorimetric assay. Level of dose enhancement for x‐ray and electron beams was also quantified using AuNps doped nPAG. Results: AuNps enhanced the cells killing up to 21 fold for 1mMol of AuNps irradiated with 80 kVp x‐ray beams. Maximum dose enhancement factor (DEF) of 4.63 was measured for 12 MeV electron beams in the presence of 1mMol AuNps. 80 kVp which represents effective beam energy of around 40 keV was the optimum energy found that yield highest enhancement ratio. Measurements using AuNps doped nPAG also exhibit higher polymerization resulting from increased photoelectric interactions, Auger electrons and characteristic x‐ray generation. The experimental dose enhancements obtained were also in agreement with theoretical calculation and those previously documented for iodine atoms. Conclusion: Both experiments with cell culture and nPAG confirm that AuNps are able to enhance the radiation dose for x‐ray and electron superficial therapy. Lower doses from external sources are required to produce the same radiation effect with AuNps compared without application of AuNps. This will lead to improvement in superficial radiotherapy techniques of both x‐ray and electron. The use of this technique with microbeam radiotherapy technique and kilovoltage type intraoperative radiotherapy techniques are now under investigation in our group.",
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Rahman, W, Bishara, N, He, C, Ackerly, T, Jackson, P, Wong, C, Davidson, R & Geso, M 2008, SU‐GG‐J‐162: Radiosensitization by Gold Nanoparticles in Superficial Radiotherapy Techniques. in Medical Physics. 6 edn, vol. 35, Medical Physics, pp. 2716. https://doi.org/10.1118/1.2961711

SU‐GG‐J‐162 : Radiosensitization by Gold Nanoparticles in Superficial Radiotherapy Techniques. / Rahman, W.; Bishara, N.; He, C.; Ackerly, T.; Jackson, P.; Wong, C.; Davidson, R.; Geso, M.

Medical Physics. Vol. 35 6. ed. 2008. p. 2716 (Medical Physics).

Research output: A Conference proceeding or a Chapter in BookConference contribution

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T2 - Radiosensitization by Gold Nanoparticles in Superficial Radiotherapy Techniques

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AU - Bishara, N.

AU - He, C.

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AU - Jackson, P.

AU - Wong, C.

AU - Davidson, R.

AU - Geso, M.

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N2 - Purpose: To investigate the radiosensitization of superficial kilovoltage range of x‐ray energy and megavoltage electron beams due to the presence of gold nanoparticles (AuNps) using cell survival curves and normoxic polyacrymide gel (nPAG). Method and Materials: Bovine aortic endothelial cells (BAECs) with and without AuNps were irradiated with kilovoltage superficial x‐ray beams and megavoltage electron beams. Cell survival at various concentrations of AuNps (0.25mMol–1mMol) was measured using colorimetric assay. Level of dose enhancement for x‐ray and electron beams was also quantified using AuNps doped nPAG. Results: AuNps enhanced the cells killing up to 21 fold for 1mMol of AuNps irradiated with 80 kVp x‐ray beams. Maximum dose enhancement factor (DEF) of 4.63 was measured for 12 MeV electron beams in the presence of 1mMol AuNps. 80 kVp which represents effective beam energy of around 40 keV was the optimum energy found that yield highest enhancement ratio. Measurements using AuNps doped nPAG also exhibit higher polymerization resulting from increased photoelectric interactions, Auger electrons and characteristic x‐ray generation. The experimental dose enhancements obtained were also in agreement with theoretical calculation and those previously documented for iodine atoms. Conclusion: Both experiments with cell culture and nPAG confirm that AuNps are able to enhance the radiation dose for x‐ray and electron superficial therapy. Lower doses from external sources are required to produce the same radiation effect with AuNps compared without application of AuNps. This will lead to improvement in superficial radiotherapy techniques of both x‐ray and electron. The use of this technique with microbeam radiotherapy technique and kilovoltage type intraoperative radiotherapy techniques are now under investigation in our group.

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Rahman W, Bishara N, He C, Ackerly T, Jackson P, Wong C et al. SU‐GG‐J‐162: Radiosensitization by Gold Nanoparticles in Superficial Radiotherapy Techniques. In Medical Physics. 6 ed. Vol. 35. 2008. p. 2716. (Medical Physics). https://doi.org/10.1118/1.2961711