Suppressor of cytokine signaling 4 (SOCS4)

Moderator of ovarian primordial follicle activation

J. M. Sutherland, R. A. Keightley, B. Nixon, S. D. Roman, R. L. Robker, D. L. Russell, E. A. Mclaughlin

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Mammalian ovarian primordial follicle activation and regulation is considered as one of the most important stages of folliculogenesis and as such requires exquisite control. Selection of quiescent follicles to enter the growing pool determines the rate of supply of maturing follicles over the female reproductive lifespan. To coordinate this process a range of positive and negative input signals contribute to determine follicle fate. This study demonstrates that the cytokine Leukemia Inhibitory Factor (LIF) activates the Janus Kinase 1/Signal Transducers and Activators of Transcription 3 (JAK1/STAT3) signaling pathway in pre-granulosa cells and positively regulates primordial follicle activation. Negative regulation of the JAK/STAT pathway is controlled by the suppressor of cytokine signaling 4 (SOCS4) protein, which target members of negative feedback loops, Cardiotrophin like Cytokine (CLC), Poly (rC) Binding Protein 1 (PCBP1), and Cytosolic Malate Dehydrogenase (MDH1) to suppress follicle growth and development.

Original languageEnglish
Pages (from-to)1188-1198
Number of pages11
JournalJournal of Cellular Physiology
Volume227
Issue number3
DOIs
Publication statusPublished - Mar 2012
Externally publishedYes

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Janus Kinase 1
Suppressor of Cytokine Signaling Proteins
Leukemia Inhibitory Factor
STAT3 Transcription Factor
Malate Dehydrogenase
Ovarian Follicle
Moderators
Granulosa Cells
Growth and Development
Carrier Proteins
Chemical activation
Cytokines
Feedback
Proteins
cardiotrophin-like cytokine

Cite this

Sutherland, J. M., Keightley, R. A., Nixon, B., Roman, S. D., Robker, R. L., Russell, D. L., & Mclaughlin, E. A. (2012). Suppressor of cytokine signaling 4 (SOCS4): Moderator of ovarian primordial follicle activation. Journal of Cellular Physiology, 227(3), 1188-1198. https://doi.org/10.1002/jcp.22837
Sutherland, J. M. ; Keightley, R. A. ; Nixon, B. ; Roman, S. D. ; Robker, R. L. ; Russell, D. L. ; Mclaughlin, E. A. / Suppressor of cytokine signaling 4 (SOCS4) : Moderator of ovarian primordial follicle activation. In: Journal of Cellular Physiology. 2012 ; Vol. 227, No. 3. pp. 1188-1198.
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Sutherland, JM, Keightley, RA, Nixon, B, Roman, SD, Robker, RL, Russell, DL & Mclaughlin, EA 2012, 'Suppressor of cytokine signaling 4 (SOCS4): Moderator of ovarian primordial follicle activation', Journal of Cellular Physiology, vol. 227, no. 3, pp. 1188-1198. https://doi.org/10.1002/jcp.22837

Suppressor of cytokine signaling 4 (SOCS4) : Moderator of ovarian primordial follicle activation. / Sutherland, J. M.; Keightley, R. A.; Nixon, B.; Roman, S. D.; Robker, R. L.; Russell, D. L.; Mclaughlin, E. A.

In: Journal of Cellular Physiology, Vol. 227, No. 3, 03.2012, p. 1188-1198.

Research output: Contribution to journalArticle

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Sutherland JM, Keightley RA, Nixon B, Roman SD, Robker RL, Russell DL et al. Suppressor of cytokine signaling 4 (SOCS4): Moderator of ovarian primordial follicle activation. Journal of Cellular Physiology. 2012 Mar;227(3):1188-1198. https://doi.org/10.1002/jcp.22837