Synthesis of some novel D-glucuronic acid acetylated derivatives as potential anti-tumor agents

Ahmed O.H. El-Nezhawy, Frady G. Adly, Ahmed F. Eweas, Atef G. Hanna, Yehya M. El-Kholy, Shahenaz H. El-Sayed, Tarek B.A. El-Naggar

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

A structurally diverse series of Δ 4,5-uronamide derivatives have been chemically synthesized starting from D-glucuronic acid itself by means of acetylation, activation, amide bond formation and base-catalyzed elimination protocols. Structure elucidation for all products along with optimization of the synthetic steps is described. The synthesized compounds were evaluated for their in-vitro anti-tumor activity against MCF-7, TK-10 and UACC-62 cell lines. The compounds 5, 11, 13, 15 and 16 were the most active against TK-10 cell line. On the other hand, the most active compounds against the MCF-7 cell line were 11 and 15. However, compounds 5, 7, 11, 13, 15 and 16 were the most active against the UACC-62 cell line.

Original languageEnglish
Pages (from-to)648-657
Number of pages10
JournalArchiv der Pharmazie
Volume344
Issue number10
DOIs
Publication statusPublished - Oct 2011
Externally publishedYes

Fingerprint Dive into the research topics of 'Synthesis of some novel D-glucuronic acid acetylated derivatives as potential anti-tumor agents'. Together they form a unique fingerprint.

  • Cite this

    El-Nezhawy, A. O. H., Adly, F. G., Eweas, A. F., Hanna, A. G., El-Kholy, Y. M., El-Sayed, S. H., & El-Naggar, T. B. A. (2011). Synthesis of some novel D-glucuronic acid acetylated derivatives as potential anti-tumor agents. Archiv der Pharmazie, 344(10), 648-657. https://doi.org/10.1002/ardp.201000367