Systematic review of the efficacy of pre and post-habilitation interventions in radical cystectomy pathways on health related quality of life and physical function.

Bente Jensen, S Lauridsen, N Mohamed, Catherine PATERSON, T Thomen, N Love, V Rauff Witt

Research output: Contribution to journalReview article

Abstract

Radical cystectomy (RC) is the first line treatment when patients are diagnosed with muscle invasive bladder cancer (MIBC), which includes T2-T4aN0M0 or high grade non-MIBC. RC is a highly complex procedure and includes removal of the bladder together with the prostate and seminal vesicle in me, and anterioer vaginal wall, uterus and adnexae in women and extended lymph node dissection and subsequently establishment of a urinary diversion. The procedure is associated with a high rate of postoperative morbidity and at least one
complication experienced in 60% of the patients within 90 days post-surgery. The population is characterized by a mean age of 68 years and a high comorbidity index. Preoperatively approximately 27% of the patients
are at severe nutritional risk, 70% are former smokers, wheras 30% are current smokers. Across Europe 30 -40 % have undergone neoadjuvant chemotherapy if tolerated. In total the candidates for RC are considered frail.The increased clinical interest in systematic prehabilitation interventions (including nutritional and physical optimisation, smoking/alcohol cessation, psycho-social support) on health related quality of life and objective functional outcomes are not clearly understood in the exiting evidence base.
Original languageEnglish
Pages (from-to)1-5
Number of pages5
JournalCentre of Systematic Reviews. PROSPERO
Publication statusPublished - 2018
Externally publishedYes

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Cystectomy
Rehabilitation
Quality of Life
Urinary Bladder Neoplasms
Urinary Diversion
Seminal Vesicles
Smoking Cessation
Lymph Node Excision
Ambulatory Surgical Procedures
Social Support
Uterus
Comorbidity
Prostate
Urinary Bladder
Alcohols
Morbidity
Drug Therapy
Muscles
Population
Therapeutics

Cite this

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title = "Systematic review of the efficacy of pre and post-habilitation interventions in radical cystectomy pathways on health related quality of life and physical function.",
abstract = "Radical cystectomy (RC) is the first line treatment when patients are diagnosed with muscle invasive bladder cancer (MIBC), which includes T2-T4aN0M0 or high grade non-MIBC. RC is a highly complex procedure and includes removal of the bladder together with the prostate and seminal vesicle in me, and anterioer vaginal wall, uterus and adnexae in women and extended lymph node dissection and subsequently establishment of a urinary diversion. The procedure is associated with a high rate of postoperative morbidity and at least onecomplication experienced in 60{\%} of the patients within 90 days post-surgery. The population is characterized by a mean age of 68 years and a high comorbidity index. Preoperatively approximately 27{\%} of the patientsare at severe nutritional risk, 70{\%} are former smokers, wheras 30{\%} are current smokers. Across Europe 30 -40 {\%} have undergone neoadjuvant chemotherapy if tolerated. In total the candidates for RC are considered frail.The increased clinical interest in systematic prehabilitation interventions (including nutritional and physical optimisation, smoking/alcohol cessation, psycho-social support) on health related quality of life and objective functional outcomes are not clearly understood in the exiting evidence base.",
author = "Bente Jensen and S Lauridsen and N Mohamed and Catherine PATERSON and T Thomen and N Love and {Rauff Witt}, V",
year = "2018",
language = "English",
pages = "1--5",
journal = "Centre of Systematic Reviews. PROSPERO",

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Systematic review of the efficacy of pre and post-habilitation interventions in radical cystectomy pathways on health related quality of life and physical function. / Jensen, Bente; Lauridsen, S; Mohamed, N; PATERSON, Catherine; Thomen, T; Love, N; Rauff Witt, V.

In: Centre of Systematic Reviews. PROSPERO, 2018, p. 1-5.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Systematic review of the efficacy of pre and post-habilitation interventions in radical cystectomy pathways on health related quality of life and physical function.

AU - Jensen, Bente

AU - Lauridsen, S

AU - Mohamed, N

AU - PATERSON, Catherine

AU - Thomen, T

AU - Love, N

AU - Rauff Witt, V

PY - 2018

Y1 - 2018

N2 - Radical cystectomy (RC) is the first line treatment when patients are diagnosed with muscle invasive bladder cancer (MIBC), which includes T2-T4aN0M0 or high grade non-MIBC. RC is a highly complex procedure and includes removal of the bladder together with the prostate and seminal vesicle in me, and anterioer vaginal wall, uterus and adnexae in women and extended lymph node dissection and subsequently establishment of a urinary diversion. The procedure is associated with a high rate of postoperative morbidity and at least onecomplication experienced in 60% of the patients within 90 days post-surgery. The population is characterized by a mean age of 68 years and a high comorbidity index. Preoperatively approximately 27% of the patientsare at severe nutritional risk, 70% are former smokers, wheras 30% are current smokers. Across Europe 30 -40 % have undergone neoadjuvant chemotherapy if tolerated. In total the candidates for RC are considered frail.The increased clinical interest in systematic prehabilitation interventions (including nutritional and physical optimisation, smoking/alcohol cessation, psycho-social support) on health related quality of life and objective functional outcomes are not clearly understood in the exiting evidence base.

AB - Radical cystectomy (RC) is the first line treatment when patients are diagnosed with muscle invasive bladder cancer (MIBC), which includes T2-T4aN0M0 or high grade non-MIBC. RC is a highly complex procedure and includes removal of the bladder together with the prostate and seminal vesicle in me, and anterioer vaginal wall, uterus and adnexae in women and extended lymph node dissection and subsequently establishment of a urinary diversion. The procedure is associated with a high rate of postoperative morbidity and at least onecomplication experienced in 60% of the patients within 90 days post-surgery. The population is characterized by a mean age of 68 years and a high comorbidity index. Preoperatively approximately 27% of the patientsare at severe nutritional risk, 70% are former smokers, wheras 30% are current smokers. Across Europe 30 -40 % have undergone neoadjuvant chemotherapy if tolerated. In total the candidates for RC are considered frail.The increased clinical interest in systematic prehabilitation interventions (including nutritional and physical optimisation, smoking/alcohol cessation, psycho-social support) on health related quality of life and objective functional outcomes are not clearly understood in the exiting evidence base.

M3 - Review article

SP - 1

EP - 5

JO - Centre of Systematic Reviews. PROSPERO

JF - Centre of Systematic Reviews. PROSPERO

ER -