TY - JOUR
T1 - The association between homocysteine levels, Mediterranean diet and cardiovascular disease
T2 - a case-control study
AU - Foscolou, Alexandra
AU - Rallidis, Loukianos S.
AU - Tsirebolos, George
AU - Critselis, Elena
AU - Katsimardos, Andreas
AU - Drosatos, Alexandros
AU - Chrysohoou, Christina
AU - Tousoulis, Dimitrios
AU - Pitsavos, Christos
AU - Panagiotakos, Demosthenes B.
N1 - Publisher Copyright:
© 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2019/7/4
Y1 - 2019/7/4
N2 - The aim was to investigate the association between homocysteine (Hcy) and acute coronary syndrome (ACS) and to test the potential moderating role of Mediterranean diet. An age and gender matched case-control study was conducted among 1491 patients with a first ACS event and 3037 adults free of cardiovascular disease (CVD). Adherence to the Mediterranean diet was measured using the MedDietScore (range 0–55). An increase in Hcy levels was associated with a 1% and 3% higher likelihood of ACS among younger (<45 yrs) and middle-aged (45–60yrs) adults (p’s < 0.05), but not in older adults (p = 0.13). Moreover, Hcy was associated with 3% (95%CI: 1.01–1.06) increase in the likelihood of ACS among those who did not adhere to the Mediterranean diet. Hence, Hcy is apparently independently associated with ACS among younger and middle-aged individuals. The inverse association between Mediterranean diet adherence and Hcy highlights a disease-preventing effect of the Mediterranean diet on CVD.
AB - The aim was to investigate the association between homocysteine (Hcy) and acute coronary syndrome (ACS) and to test the potential moderating role of Mediterranean diet. An age and gender matched case-control study was conducted among 1491 patients with a first ACS event and 3037 adults free of cardiovascular disease (CVD). Adherence to the Mediterranean diet was measured using the MedDietScore (range 0–55). An increase in Hcy levels was associated with a 1% and 3% higher likelihood of ACS among younger (<45 yrs) and middle-aged (45–60yrs) adults (p’s < 0.05), but not in older adults (p = 0.13). Moreover, Hcy was associated with 3% (95%CI: 1.01–1.06) increase in the likelihood of ACS among those who did not adhere to the Mediterranean diet. Hence, Hcy is apparently independently associated with ACS among younger and middle-aged individuals. The inverse association between Mediterranean diet adherence and Hcy highlights a disease-preventing effect of the Mediterranean diet on CVD.
KW - aging
KW - cardiovascular disease
KW - Homocysteine
KW - Mediterranean diet
UR - http://www.scopus.com/inward/record.url?scp=85058096542&partnerID=8YFLogxK
U2 - 10.1080/09637486.2018.1547688
DO - 10.1080/09637486.2018.1547688
M3 - Article
C2 - 30501542
AN - SCOPUS:85058096542
SN - 0963-7486
VL - 70
SP - 603
EP - 611
JO - International Journal of Food Sciences and Nutrition
JF - International Journal of Food Sciences and Nutrition
IS - 5
ER -
