The association between homocysteine levels, Mediterranean diet and cardiovascular disease: a case-control study

Alexandra Foscolou, Loukianos S. Rallidis, George Tsirebolos, Elena Critselis, Andreas Katsimardos, Alexandros Drosatos, Christina Chrysohoou, Dimitrios Tousoulis, Christos Pitsavos, Demosthenes B. Panagiotakos

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

The aim was to investigate the association between homocysteine (Hcy) and acute coronary syndrome (ACS) and to test the potential moderating role of Mediterranean diet. An age and gender matched case-control study was conducted among 1491 patients with a first ACS event and 3037 adults free of cardiovascular disease (CVD). Adherence to the Mediterranean diet was measured using the MedDietScore (range 0–55). An increase in Hcy levels was associated with a 1% and 3% higher likelihood of ACS among younger (<45 yrs) and middle-aged (45–60yrs) adults (p’s < 0.05), but not in older adults (p = 0.13). Moreover, Hcy was associated with 3% (95%CI: 1.01–1.06) increase in the likelihood of ACS among those who did not adhere to the Mediterranean diet. Hence, Hcy is apparently independently associated with ACS among younger and middle-aged individuals. The inverse association between Mediterranean diet adherence and Hcy highlights a disease-preventing effect of the Mediterranean diet on CVD.

Original languageEnglish
Pages (from-to)603-611
Number of pages9
JournalInternational Journal of Food Sciences and Nutrition
Volume70
Issue number5
DOIs
Publication statusPublished - 4 Jul 2019
Externally publishedYes

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