The biological and clinical significance of stromal-epithelial interactions in breast cancer

Robert MCCUAIG, Fan Wu, Jenny DUNN, Sudha RAO, Jane Dahlstrom

Research output: Contribution to journalArticle

11 Citations (Scopus)
8 Downloads (Pure)

Abstract

There is evidence that an aberrant tumour microenvironment (TME) facilitates cancer development, progression, and responses to treatment. While many of the mechanisms underlying the phenotype and cancer-promoting behaviour of the TME are unknown, epigenetic mechanisms in cancer cells and the TME are thought to play important roles. As a result, cancer profiling strategies for drug and biomarker development require a thorough understanding of both the epithelial tissue compartment and the TME. This review discusses recent advances in our understanding of how cancer epithelial cells interact with their microenvironment and how this knowledge can be exploited clinically.
Original languageEnglish
Pages (from-to)133-140
Number of pages8
JournalPathology
Volume49
Issue number2
DOIs
Publication statusPublished - 2017

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Tumor Microenvironment
Breast Neoplasms
Neoplasms
Cellular Microenvironment
Epigenomics
Epithelium
Biomarkers
Epithelial Cells
Phenotype
Pharmaceutical Preparations

Cite this

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abstract = "There is evidence that an aberrant tumour microenvironment (TME) facilitates cancer development, progression, and responses to treatment. While many of the mechanisms underlying the phenotype and cancer-promoting behaviour of the TME are unknown, epigenetic mechanisms in cancer cells and the TME are thought to play important roles. As a result, cancer profiling strategies for drug and biomarker development require a thorough understanding of both the epithelial tissue compartment and the TME. This review discusses recent advances in our understanding of how cancer epithelial cells interact with their microenvironment and how this knowledge can be exploited clinically.",
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The biological and clinical significance of stromal-epithelial interactions in breast cancer. / MCCUAIG, Robert; Wu, Fan; DUNN, Jenny; RAO, Sudha; Dahlstrom, Jane.

In: Pathology, Vol. 49, No. 2, 2017, p. 133-140.

Research output: Contribution to journalArticle

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T1 - The biological and clinical significance of stromal-epithelial interactions in breast cancer

AU - MCCUAIG, Robert

AU - Wu, Fan

AU - DUNN, Jenny

AU - RAO, Sudha

AU - Dahlstrom, Jane

PY - 2017

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N2 - There is evidence that an aberrant tumour microenvironment (TME) facilitates cancer development, progression, and responses to treatment. While many of the mechanisms underlying the phenotype and cancer-promoting behaviour of the TME are unknown, epigenetic mechanisms in cancer cells and the TME are thought to play important roles. As a result, cancer profiling strategies for drug and biomarker development require a thorough understanding of both the epithelial tissue compartment and the TME. This review discusses recent advances in our understanding of how cancer epithelial cells interact with their microenvironment and how this knowledge can be exploited clinically.

AB - There is evidence that an aberrant tumour microenvironment (TME) facilitates cancer development, progression, and responses to treatment. While many of the mechanisms underlying the phenotype and cancer-promoting behaviour of the TME are unknown, epigenetic mechanisms in cancer cells and the TME are thought to play important roles. As a result, cancer profiling strategies for drug and biomarker development require a thorough understanding of both the epithelial tissue compartment and the TME. This review discusses recent advances in our understanding of how cancer epithelial cells interact with their microenvironment and how this knowledge can be exploited clinically.

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KW - cancer associated fibroblasts

KW - cancer stem cells

KW - DNA methylation

KW - epi-drugs

KW - epigenetics

KW - histone

KW - tumour microenvironment

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