The biological and clinical significance of stromal-epithelial interactions in breast cancer

Robert MCCUAIG, Fan Wu, Jenny DUNN, Sudha RAO, Jane Dahlstrom

Research output: Contribution to journalArticle

16 Citations (Scopus)
14 Downloads (Pure)

Abstract

There is evidence that an aberrant tumour microenvironment (TME) facilitates cancer development, progression, and responses to treatment. While many of the mechanisms underlying the phenotype and cancer-promoting behaviour of the TME are unknown, epigenetic mechanisms in cancer cells and the TME are thought to play important roles. As a result, cancer profiling strategies for drug and biomarker development require a thorough understanding of both the epithelial tissue compartment and the TME. This review discusses recent advances in our understanding of how cancer epithelial cells interact with their microenvironment and how this knowledge can be exploited clinically.
Original languageEnglish
Pages (from-to)133-140
Number of pages8
JournalPathology
Volume49
Issue number2
DOIs
Publication statusPublished - 2017

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