The biology of cancer-related fatigue: a review of the literature

L Saligan; K Olson; K Filler; David Larkin; F Cramp; Y Sriram; C Escalante; A del Giglio; K Kober; J Kamath; O Palesh; K Mustian

doi:10.1007/s00520-015-2763-0

The biology of cancer-related fatigue: a review of the literature

L Saligan, K Olson, K Filler, David Larkin, F Cramp, Y Sriram, C Escalante, A del Giglio, K Kober, J Kamath, O Palesh, K Mustian

Research output: Contribution to journal › Review article › peer-review

224 Citations (Scopus)

Abstract

Purpose: Understanding the etiology of cancer-related fatigue (CRF) is critical to identify targets to develop therapies to reduce CRF burden. The goal of this systematic review was to expand on the initial work by the National Cancer Institute CRF Working Group to understand the state of the science related to the biology of CRF and, specifically, to evaluate studies that examined the relationships between biomarkers and CRF and to develop an etiologic model of CRF to guide researchers on pathways to explore or therapeutic targets to investigate. Methods: This review was completed by the Multinational Association of Supportive Care in Cancer Fatigue Study Group–Biomarker Working Group. The initial search used three terms (biomarkers, fatigue, cancer), which yielded 11,129 articles. After removing duplicates, 9145 articles remained. Titles were assessed for the keywords “cancer” and “fatigue” resulting in 3811 articles. Articles published before 2010 and those with samples

Original language	English
Pages (from-to)	2461-2478
Number of pages	18
Journal	Supportive Care in Cancer
Volume	23
Issue number	8
DOIs	https://doi.org/10.1007/s00520-015-2763-0
Publication status	Published - 29 Aug 2015

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10.1007/s00520-015-2763-0

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4484308/

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title = "The biology of cancer-related fatigue: a review of the literature",

abstract = "Purpose: Understanding the etiology of cancer-related fatigue (CRF) is critical to identify targets to develop therapies to reduce CRF burden. The goal of this systematic review was to expand on the initial work by the National Cancer Institute CRF Working Group to understand the state of the science related to the biology of CRF and, specifically, to evaluate studies that examined the relationships between biomarkers and CRF and to develop an etiologic model of CRF to guide researchers on pathways to explore or therapeutic targets to investigate. Methods: This review was completed by the Multinational Association of Supportive Care in Cancer Fatigue Study Group–Biomarker Working Group. The initial search used three terms (biomarkers, fatigue, cancer), which yielded 11,129 articles. After removing duplicates, 9145 articles remained. Titles were assessed for the keywords “cancer” and “fatigue” resulting in 3811 articles. Articles published before 2010 and those with samples",

keywords = "Cancer-related fatigue, Genetic, Inflammation, Metabolic, Neuroendocrine",

author = "L Saligan and K Olson and K Filler and David Larkin and F Cramp and Y Sriram and C Escalante and {del Giglio}, A and K Kober and J Kamath and O Palesh and K Mustian",

note = "Funding Information: This research was supported by the Multinational Association of Supportive Care in Cancer and the Division of Intramural Research, National Institute of Nursing Research, National Institutes of Health, and Grants NCI K07CA120025, UG1 CA189961 and R01 CA181064. Publisher Copyright: {\textcopyright} 2015, Springer-Verlag Berlin Heidelberg (Outside the USA).",

year = "2015",

month = aug,

day = "29",

doi = "10.1007/s00520-015-2763-0",

language = "English",

volume = "23",

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journal = "Supportive Care in Cancer",

issn = "0941-4355",

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T1 - The biology of cancer-related fatigue: a review of the literature

AU - Saligan, L

AU - Olson, K

AU - Filler, K

AU - Larkin, David

AU - Cramp, F

AU - Sriram, Y

AU - Escalante, C

AU - del Giglio, A

AU - Kober, K

AU - Kamath, J

AU - Palesh, O

AU - Mustian, K

N1 - Funding Information: This research was supported by the Multinational Association of Supportive Care in Cancer and the Division of Intramural Research, National Institute of Nursing Research, National Institutes of Health, and Grants NCI K07CA120025, UG1 CA189961 and R01 CA181064. Publisher Copyright: © 2015, Springer-Verlag Berlin Heidelberg (Outside the USA).

PY - 2015/8/29

Y1 - 2015/8/29

N2 - Purpose: Understanding the etiology of cancer-related fatigue (CRF) is critical to identify targets to develop therapies to reduce CRF burden. The goal of this systematic review was to expand on the initial work by the National Cancer Institute CRF Working Group to understand the state of the science related to the biology of CRF and, specifically, to evaluate studies that examined the relationships between biomarkers and CRF and to develop an etiologic model of CRF to guide researchers on pathways to explore or therapeutic targets to investigate. Methods: This review was completed by the Multinational Association of Supportive Care in Cancer Fatigue Study Group–Biomarker Working Group. The initial search used three terms (biomarkers, fatigue, cancer), which yielded 11,129 articles. After removing duplicates, 9145 articles remained. Titles were assessed for the keywords “cancer” and “fatigue” resulting in 3811 articles. Articles published before 2010 and those with samples

AB - Purpose: Understanding the etiology of cancer-related fatigue (CRF) is critical to identify targets to develop therapies to reduce CRF burden. The goal of this systematic review was to expand on the initial work by the National Cancer Institute CRF Working Group to understand the state of the science related to the biology of CRF and, specifically, to evaluate studies that examined the relationships between biomarkers and CRF and to develop an etiologic model of CRF to guide researchers on pathways to explore or therapeutic targets to investigate. Methods: This review was completed by the Multinational Association of Supportive Care in Cancer Fatigue Study Group–Biomarker Working Group. The initial search used three terms (biomarkers, fatigue, cancer), which yielded 11,129 articles. After removing duplicates, 9145 articles remained. Titles were assessed for the keywords “cancer” and “fatigue” resulting in 3811 articles. Articles published before 2010 and those with samples

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DO - 10.1007/s00520-015-2763-0

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SP - 2461

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JO - Supportive Care in Cancer

JF - Supportive Care in Cancer

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The biology of cancer-related fatigue: a review of the literature

Abstract

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