The biology of cancer-related fatigue: a review of the literature

L Saligan, K Olson, K Filler, David Larkin, F Cramp, Y Sriram, C Escalante, A del Giglio, K Kober, J Kamath, O Palesh, K Mustian

Research output: Contribution to journalLiterature review

88 Citations (Scopus)

Abstract

Purpose: Understanding the etiology of cancer-related fatigue (CRF) is critical to identify targets to develop therapies to reduce CRF burden. The goal of this systematic review was to expand on the initial work by the National Cancer Institute CRF Working Group to understand the state of the science related to the biology of CRF and, specifically, to evaluate studies that examined the relationships between biomarkers and CRF and to develop an etiologic model of CRF to guide researchers on pathways to explore or therapeutic targets to investigate. Methods: This review was completed by the Multinational Association of Supportive Care in Cancer Fatigue Study Group–Biomarker Working Group. The initial search used three terms (biomarkers, fatigue, cancer), which yielded 11,129 articles. After removing duplicates, 9145 articles remained. Titles were assessed for the keywords “cancer” and “fatigue” resulting in 3811 articles. Articles published before 2010 and those with samples
Original languageEnglish
Pages (from-to)2461-2478
Number of pages18
JournalSupportive Care in Cancer
Volume23
Issue number8
DOIs
Publication statusPublished - 2015

Fingerprint

Fatigue
Neoplasms
Tumor Biomarkers
National Cancer Institute (U.S.)
Research Personnel
Therapeutics

Cite this

Saligan, L., Olson, K., Filler, K., Larkin, D., Cramp, F., Sriram, Y., ... Mustian, K. (2015). The biology of cancer-related fatigue: a review of the literature. Supportive Care in Cancer, 23(8), 2461-2478. https://doi.org/10.1007/s00520-015-2763-0
Saligan, L ; Olson, K ; Filler, K ; Larkin, David ; Cramp, F ; Sriram, Y ; Escalante, C ; del Giglio, A ; Kober, K ; Kamath, J ; Palesh, O ; Mustian, K. / The biology of cancer-related fatigue: a review of the literature. In: Supportive Care in Cancer. 2015 ; Vol. 23, No. 8. pp. 2461-2478.
@article{3fc9a0f3fc214afd96731e5f5f432abb,
title = "The biology of cancer-related fatigue: a review of the literature",
abstract = "Purpose: Understanding the etiology of cancer-related fatigue (CRF) is critical to identify targets to develop therapies to reduce CRF burden. The goal of this systematic review was to expand on the initial work by the National Cancer Institute CRF Working Group to understand the state of the science related to the biology of CRF and, specifically, to evaluate studies that examined the relationships between biomarkers and CRF and to develop an etiologic model of CRF to guide researchers on pathways to explore or therapeutic targets to investigate. Methods: This review was completed by the Multinational Association of Supportive Care in Cancer Fatigue Study Group–Biomarker Working Group. The initial search used three terms (biomarkers, fatigue, cancer), which yielded 11,129 articles. After removing duplicates, 9145 articles remained. Titles were assessed for the keywords “cancer” and “fatigue” resulting in 3811 articles. Articles published before 2010 and those with samples",
author = "L Saligan and K Olson and K Filler and David Larkin and F Cramp and Y Sriram and C Escalante and {del Giglio}, A and K Kober and J Kamath and O Palesh and K Mustian",
year = "2015",
doi = "10.1007/s00520-015-2763-0",
language = "English",
volume = "23",
pages = "2461--2478",
journal = "Supportive Care in Cancer",
issn = "0941-4355",
publisher = "Springer Verlag",
number = "8",

}

Saligan, L, Olson, K, Filler, K, Larkin, D, Cramp, F, Sriram, Y, Escalante, C, del Giglio, A, Kober, K, Kamath, J, Palesh, O & Mustian, K 2015, 'The biology of cancer-related fatigue: a review of the literature', Supportive Care in Cancer, vol. 23, no. 8, pp. 2461-2478. https://doi.org/10.1007/s00520-015-2763-0

The biology of cancer-related fatigue: a review of the literature. / Saligan, L; Olson, K; Filler, K; Larkin, David; Cramp, F; Sriram, Y; Escalante, C; del Giglio, A; Kober, K; Kamath, J; Palesh, O; Mustian, K.

In: Supportive Care in Cancer, Vol. 23, No. 8, 2015, p. 2461-2478.

Research output: Contribution to journalLiterature review

TY - JOUR

T1 - The biology of cancer-related fatigue: a review of the literature

AU - Saligan, L

AU - Olson, K

AU - Filler, K

AU - Larkin, David

AU - Cramp, F

AU - Sriram, Y

AU - Escalante, C

AU - del Giglio, A

AU - Kober, K

AU - Kamath, J

AU - Palesh, O

AU - Mustian, K

PY - 2015

Y1 - 2015

N2 - Purpose: Understanding the etiology of cancer-related fatigue (CRF) is critical to identify targets to develop therapies to reduce CRF burden. The goal of this systematic review was to expand on the initial work by the National Cancer Institute CRF Working Group to understand the state of the science related to the biology of CRF and, specifically, to evaluate studies that examined the relationships between biomarkers and CRF and to develop an etiologic model of CRF to guide researchers on pathways to explore or therapeutic targets to investigate. Methods: This review was completed by the Multinational Association of Supportive Care in Cancer Fatigue Study Group–Biomarker Working Group. The initial search used three terms (biomarkers, fatigue, cancer), which yielded 11,129 articles. After removing duplicates, 9145 articles remained. Titles were assessed for the keywords “cancer” and “fatigue” resulting in 3811 articles. Articles published before 2010 and those with samples

AB - Purpose: Understanding the etiology of cancer-related fatigue (CRF) is critical to identify targets to develop therapies to reduce CRF burden. The goal of this systematic review was to expand on the initial work by the National Cancer Institute CRF Working Group to understand the state of the science related to the biology of CRF and, specifically, to evaluate studies that examined the relationships between biomarkers and CRF and to develop an etiologic model of CRF to guide researchers on pathways to explore or therapeutic targets to investigate. Methods: This review was completed by the Multinational Association of Supportive Care in Cancer Fatigue Study Group–Biomarker Working Group. The initial search used three terms (biomarkers, fatigue, cancer), which yielded 11,129 articles. After removing duplicates, 9145 articles remained. Titles were assessed for the keywords “cancer” and “fatigue” resulting in 3811 articles. Articles published before 2010 and those with samples

U2 - 10.1007/s00520-015-2763-0

DO - 10.1007/s00520-015-2763-0

M3 - Literature review

VL - 23

SP - 2461

EP - 2478

JO - Supportive Care in Cancer

JF - Supportive Care in Cancer

SN - 0941-4355

IS - 8

ER -

Saligan L, Olson K, Filler K, Larkin D, Cramp F, Sriram Y et al. The biology of cancer-related fatigue: a review of the literature. Supportive Care in Cancer. 2015;23(8):2461-2478. https://doi.org/10.1007/s00520-015-2763-0