Purpose. To determine if the cat model can be used to predict on eye adherence of contact lenses in the human. Methods. A range of different materials in the form of contact lenses were assessed on eye after at least one hour of wear. Up to 10 human and 5 cat subjects were involved and similar lens designs were used in each case. Adherence was defined as any lens which displayed 100% lightness with the push up test. Beyond this, the strength of adherence as indicated by resistance to lateral digital pressure was graded on a 0-4 scale. A zero grade indicated a easily displaced lens while grade four denoted an absence of movement with even strong digital force. Results. The cat demonstrated a sensitivity of 74% and a specificity of 72% in predicting human contact lens binding. The association between the grade of adherence assessments made in cats and humans was highly significant (r = 0.69, p < 0.0001). Conclusions. This study suggests that the cat may provide a useful model for predicting the adherence of contact lenses in human eyes.
|Investigative Ophthalmology and Visual Science
|Published - 15 Feb 1996