The preliminary development of a liquid chromatography-mass spectrometry (LC/MS) method for the detection of allopurinol, and its metabolite, oxypurinol in human hair is reported. The experimental results indicate that allopurinol is not present in incoeporated hair, while oxypurinol is. Furthermore, the results indicate that the developed LC/MS method may provide a means by which clinical monitoring of oxypurinol can be achieved; an appplication of potential imporatnce due to the adverse effects associated with the occurmulation of oxypurinol in the body. The LC/MS method described is the first to detect these analytes in hair, and among the first methods to utilise LC/MS for the analysis of drugs in hair.
|Number of pages||9|
|Journal||Z Zagadnien Nauk Sadowych|
|Publication status||Published - 2000|