The digit ratio (2D:4D) relationship with testosterone is moderated by physical training

Evidence of prenatal organizational influences on activational patterns of adult testosterone in physically-active women

Blair T. Crewther, Christian J. Cook

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: The 2nd to 4th digit ratio (2D:4D) is regarded as a sexually dimorphic trait governed by prenatal testosterone (T) and estradiol exposure. However, relationships between the 2D:4D and adult sex hormone concentrations are inconsistent in females. Environmental contingencies (e.g., physical training) may provide a stronger basis for establishing these linkages, particularly if the relationships are plastic and not fixed. Aims: To investigate associations between 2D:4D, training hours and salivary T (sal-T) measures in physically-active women. Study design: Descriptive and quasi-experimental monitoring across the follicular (day 7), ovulatory (day 14) and luteal (day 21) phases of three menstrual cycles. Subjects: 35 naturally-cycling women training regularly for sport (range 3–12 h a week). Outcome measures: Morning sal-T concentrations and changes in sal-T to a physical and psychological stimulus (~10 min) were measured. Results: Both 2D:4D and training hours were related to morning sal-T concentrations in all three menstrual phases (p < 0.01) and their interaction was significant during ovulation. Follow-up testing revealed a negative 2D:4D and sal-T association in women reporting high, but not low, training hours each week. Participant 2D:4D was also related to sal-T changes under physical and/or psychological challenge across each menstrual phase (p < 0.01), whereas training hours and its interaction with 2D:4D were not significant predictors of these outcomes. Conclusions: 2D:4D linkages with basal and challenge-induced sal-T changes were identified in women undertaking regular physical training. Training hours also moderated the 2D:4D link to morning sal-T, but with some menstrual-phase dependency. These complexities and environmental relationships may help reconcile conflicting results.

Original languageEnglish
Pages (from-to)51-55
Number of pages5
JournalEarly Human Development
Volume131
DOIs
Publication statusPublished - 1 Apr 2019

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Testosterone
Psychology
Corpus Luteum
Gonadal Steroid Hormones
Menstrual Cycle
Ovulation
Plastics
Sports
Estradiol
Outcome Assessment (Health Care)

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title = "The digit ratio (2D:4D) relationship with testosterone is moderated by physical training: Evidence of prenatal organizational influences on activational patterns of adult testosterone in physically-active women",
abstract = "Background: The 2nd to 4th digit ratio (2D:4D) is regarded as a sexually dimorphic trait governed by prenatal testosterone (T) and estradiol exposure. However, relationships between the 2D:4D and adult sex hormone concentrations are inconsistent in females. Environmental contingencies (e.g., physical training) may provide a stronger basis for establishing these linkages, particularly if the relationships are plastic and not fixed. Aims: To investigate associations between 2D:4D, training hours and salivary T (sal-T) measures in physically-active women. Study design: Descriptive and quasi-experimental monitoring across the follicular (day 7), ovulatory (day 14) and luteal (day 21) phases of three menstrual cycles. Subjects: 35 naturally-cycling women training regularly for sport (range 3–12 h a week). Outcome measures: Morning sal-T concentrations and changes in sal-T to a physical and psychological stimulus (~10 min) were measured. Results: Both 2D:4D and training hours were related to morning sal-T concentrations in all three menstrual phases (p < 0.01) and their interaction was significant during ovulation. Follow-up testing revealed a negative 2D:4D and sal-T association in women reporting high, but not low, training hours each week. Participant 2D:4D was also related to sal-T changes under physical and/or psychological challenge across each menstrual phase (p < 0.01), whereas training hours and its interaction with 2D:4D were not significant predictors of these outcomes. Conclusions: 2D:4D linkages with basal and challenge-induced sal-T changes were identified in women undertaking regular physical training. Training hours also moderated the 2D:4D link to morning sal-T, but with some menstrual-phase dependency. These complexities and environmental relationships may help reconcile conflicting results.",
keywords = "Androgens, Behaviour, Competition, Estrogen, Saliva, Stress",
author = "Crewther, {Blair T.} and Cook, {Christian J.}",
year = "2019",
month = "4",
day = "1",
doi = "10.1016/j.earlhumdev.2019.02.008",
language = "English",
volume = "131",
pages = "51--55",
journal = "Screening",
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publisher = "Elsevier Ireland Ltd",

}

TY - JOUR

T1 - The digit ratio (2D:4D) relationship with testosterone is moderated by physical training

T2 - Evidence of prenatal organizational influences on activational patterns of adult testosterone in physically-active women

AU - Crewther, Blair T.

AU - Cook, Christian J.

PY - 2019/4/1

Y1 - 2019/4/1

N2 - Background: The 2nd to 4th digit ratio (2D:4D) is regarded as a sexually dimorphic trait governed by prenatal testosterone (T) and estradiol exposure. However, relationships between the 2D:4D and adult sex hormone concentrations are inconsistent in females. Environmental contingencies (e.g., physical training) may provide a stronger basis for establishing these linkages, particularly if the relationships are plastic and not fixed. Aims: To investigate associations between 2D:4D, training hours and salivary T (sal-T) measures in physically-active women. Study design: Descriptive and quasi-experimental monitoring across the follicular (day 7), ovulatory (day 14) and luteal (day 21) phases of three menstrual cycles. Subjects: 35 naturally-cycling women training regularly for sport (range 3–12 h a week). Outcome measures: Morning sal-T concentrations and changes in sal-T to a physical and psychological stimulus (~10 min) were measured. Results: Both 2D:4D and training hours were related to morning sal-T concentrations in all three menstrual phases (p < 0.01) and their interaction was significant during ovulation. Follow-up testing revealed a negative 2D:4D and sal-T association in women reporting high, but not low, training hours each week. Participant 2D:4D was also related to sal-T changes under physical and/or psychological challenge across each menstrual phase (p < 0.01), whereas training hours and its interaction with 2D:4D were not significant predictors of these outcomes. Conclusions: 2D:4D linkages with basal and challenge-induced sal-T changes were identified in women undertaking regular physical training. Training hours also moderated the 2D:4D link to morning sal-T, but with some menstrual-phase dependency. These complexities and environmental relationships may help reconcile conflicting results.

AB - Background: The 2nd to 4th digit ratio (2D:4D) is regarded as a sexually dimorphic trait governed by prenatal testosterone (T) and estradiol exposure. However, relationships between the 2D:4D and adult sex hormone concentrations are inconsistent in females. Environmental contingencies (e.g., physical training) may provide a stronger basis for establishing these linkages, particularly if the relationships are plastic and not fixed. Aims: To investigate associations between 2D:4D, training hours and salivary T (sal-T) measures in physically-active women. Study design: Descriptive and quasi-experimental monitoring across the follicular (day 7), ovulatory (day 14) and luteal (day 21) phases of three menstrual cycles. Subjects: 35 naturally-cycling women training regularly for sport (range 3–12 h a week). Outcome measures: Morning sal-T concentrations and changes in sal-T to a physical and psychological stimulus (~10 min) were measured. Results: Both 2D:4D and training hours were related to morning sal-T concentrations in all three menstrual phases (p < 0.01) and their interaction was significant during ovulation. Follow-up testing revealed a negative 2D:4D and sal-T association in women reporting high, but not low, training hours each week. Participant 2D:4D was also related to sal-T changes under physical and/or psychological challenge across each menstrual phase (p < 0.01), whereas training hours and its interaction with 2D:4D were not significant predictors of these outcomes. Conclusions: 2D:4D linkages with basal and challenge-induced sal-T changes were identified in women undertaking regular physical training. Training hours also moderated the 2D:4D link to morning sal-T, but with some menstrual-phase dependency. These complexities and environmental relationships may help reconcile conflicting results.

KW - Androgens

KW - Behaviour

KW - Competition

KW - Estrogen

KW - Saliva

KW - Stress

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U2 - 10.1016/j.earlhumdev.2019.02.008

DO - 10.1016/j.earlhumdev.2019.02.008

M3 - Article

VL - 131

SP - 51

EP - 55

JO - Screening

JF - Screening

SN - 0378-3782

ER -