The discovery and characterization of a novel scaffold as a potent hepatitis C virus inhibitor

Na Liu, Shiping Zhu, Xianghua Zhang, Xunkui Yin, Guoqiang Dong, Jianzhong Yao, Zhenyuan Miao, Wannian Zhang, Xiaonan Zhang, Chunquan Sheng

Research output: Contribution to journalReview articlepeer-review

5 Citations (Scopus)

Abstract

HCV infections are a major global health concern. Although direct acting antiviral agents have significantly improved the response rate of anti-HCV therapy, they also suffer from drug resistance, unfavorable pharmacokinetic profiles and high costs. Thus, it is still highly desirable to develop new anti-HCV therapeutics. Herein a novel anti-HCV benzothiazole scaffold was discovered by phenotypic screening. Further target characterization and structural optimization studies revealed that the benzothiazole-disulfoamide derivatives were potent anti-HCV molecules with good selectivity and acted by targeting NS5A.

Original languageEnglish
Pages (from-to)3340-3343
Number of pages4
JournalChemical Communications
Volume52
Issue number16
DOIs
Publication statusPublished - 25 Feb 2016
Externally publishedYes

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