@article{15cf7ade78714d5e963d3da2bfe791ab,
title = "The discovery and characterization of a novel scaffold as a potent hepatitis C virus inhibitor",
abstract = "HCV infections are a major global health concern. Although direct acting antiviral agents have significantly improved the response rate of anti-HCV therapy, they also suffer from drug resistance, unfavorable pharmacokinetic profiles and high costs. Thus, it is still highly desirable to develop new anti-HCV therapeutics. Herein a novel anti-HCV benzothiazole scaffold was discovered by phenotypic screening. Further target characterization and structural optimization studies revealed that the benzothiazole-disulfoamide derivatives were potent anti-HCV molecules with good selectivity and acted by targeting NS5A. ",
keywords = "Antiviral Agents/pharmacology, Drug Discovery, Hepacivirus/drug effects",
author = "Na Liu and Shiping Zhu and Xianghua Zhang and Xunkui Yin and Guoqiang Dong and Jianzhong Yao and Zhenyuan Miao and Wannian Zhang and Xiaonan Zhang and Chunquan Sheng",
note = "Funding Information: Financial support for this research was provided by the 863 Hi-Tech Program of China (Grant 2014AA020525 to C. S.), the National Natural Science Foundation of China (Grant 8122044 to C. S. and 81201278 to X. Z.), the Youth Foundation of Second Military Medical University (grant 2014QN06 to N. L.) and the Shanghai ??ShuGuang?? Project (grant 14SG33 to C. S.). Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2016. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",
year = "2016",
month = feb,
day = "25",
doi = "10.1039/c5cc10594c",
language = "English",
volume = "52",
pages = "3340--3343",
journal = "Chemical Communications",
issn = "1359-7345",
publisher = "Royal Society of Chemistry",
number = "16",
}