The distribution of cardiac troponin I in a population of healthy children: Lessons for adults

Gus KOERBIN, Julia M. Potter, Walter P. Abhayaratna, Rohan Telford, Peter E. Hickman

Research output: Contribution to journalArticle

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Abstract

Objectives: To describe the distribution of hs-cTnI in a large cohort of healthy children.

Design and methods: As part of the LOOK study, blood was collected from a large cohort of healthy children on 3 separate occasions when the children were aged 8, 10 and 12 years. Samples were stored at -80 degrees C after collection and assayed after 1 freeze-thaw cycle using a pre-commercial release hs-cTnI assay from Abbott Diagnostics.

Results: More than 98% of the 12 year-old children had cTnI above the LoD of 1.0 ng/L. For the 212 boys the central 95% of results was distributed in a Gaussian fashion. For the 237 girls, the initial analysis was non-Gaussian, but after the elimination of 2 results, the pattern for girls was also Gaussian.

Conclusions: In healthy children, cTnI is present in a Gaussian distribution. Even minor illnesses can cause some troponin release, distorting this Gaussian distribution
Original languageEnglish
Pages (from-to)54-56
Number of pages3
JournalClinica Chimica Acta
Volume417
DOIs
Publication statusPublished - 2013

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Troponin I
Gaussian distribution
Troponin
Population
Normal Distribution
Assays
Blood

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KOERBIN, Gus ; Potter, Julia M. ; Abhayaratna, Walter P. ; Telford, Rohan ; Hickman, Peter E. / The distribution of cardiac troponin I in a population of healthy children: Lessons for adults. In: Clinica Chimica Acta. 2013 ; Vol. 417. pp. 54-56.
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The distribution of cardiac troponin I in a population of healthy children: Lessons for adults. / KOERBIN, Gus; Potter, Julia M.; Abhayaratna, Walter P.; Telford, Rohan; Hickman, Peter E.

In: Clinica Chimica Acta, Vol. 417, 2013, p. 54-56.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The distribution of cardiac troponin I in a population of healthy children: Lessons for adults

AU - KOERBIN, Gus

AU - Potter, Julia M.

AU - Abhayaratna, Walter P.

AU - Telford, Rohan

AU - Hickman, Peter E.

PY - 2013

Y1 - 2013

N2 - Objectives: To describe the distribution of hs-cTnI in a large cohort of healthy children. Design and methods: As part of the LOOK study, blood was collected from a large cohort of healthy children on 3 separate occasions when the children were aged 8, 10 and 12 years. Samples were stored at -80 degrees C after collection and assayed after 1 freeze-thaw cycle using a pre-commercial release hs-cTnI assay from Abbott Diagnostics. Results: More than 98% of the 12 year-old children had cTnI above the LoD of 1.0 ng/L. For the 212 boys the central 95% of results was distributed in a Gaussian fashion. For the 237 girls, the initial analysis was non-Gaussian, but after the elimination of 2 results, the pattern for girls was also Gaussian. Conclusions: In healthy children, cTnI is present in a Gaussian distribution. Even minor illnesses can cause some troponin release, distorting this Gaussian distribution

AB - Objectives: To describe the distribution of hs-cTnI in a large cohort of healthy children. Design and methods: As part of the LOOK study, blood was collected from a large cohort of healthy children on 3 separate occasions when the children were aged 8, 10 and 12 years. Samples were stored at -80 degrees C after collection and assayed after 1 freeze-thaw cycle using a pre-commercial release hs-cTnI assay from Abbott Diagnostics. Results: More than 98% of the 12 year-old children had cTnI above the LoD of 1.0 ng/L. For the 212 boys the central 95% of results was distributed in a Gaussian fashion. For the 237 girls, the initial analysis was non-Gaussian, but after the elimination of 2 results, the pattern for girls was also Gaussian. Conclusions: In healthy children, cTnI is present in a Gaussian distribution. Even minor illnesses can cause some troponin release, distorting this Gaussian distribution

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