The distribution of cardiac troponin I in a population of healthy children: Lessons for adults

Gus KOERBIN, Julia M. Potter, Walter P. Abhayaratna, Richard D. Telford, Peter E. Hickman

    Research output: Contribution to journalArticlepeer-review

    15 Citations (Scopus)

    Abstract

    Objectives: To describe the distribution of hs-cTnI in a large cohort of healthy children.

    Design and methods: As part of the LOOK study, blood was collected from a large cohort of healthy children on 3 separate occasions when the children were aged 8, 10 and 12 years. Samples were stored at -80 degrees C after collection and assayed after 1 freeze-thaw cycle using a pre-commercial release hs-cTnI assay from Abbott Diagnostics.

    Results: More than 98% of the 12 year-old children had cTnI above the LoD of 1.0 ng/L. For the 212 boys the central 95% of results was distributed in a Gaussian fashion. For the 237 girls, the initial analysis was non-Gaussian, but after the elimination of 2 results, the pattern for girls was also Gaussian.

    Conclusions: In healthy children, cTnI is present in a Gaussian distribution. Even minor illnesses can cause some troponin release, distorting this Gaussian distribution
    Original languageEnglish
    Pages (from-to)54-56
    Number of pages3
    JournalClinica Chimica Acta
    Volume417
    DOIs
    Publication statusPublished - 2013

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