Abstract
Objectives: To describe the distribution of hs-cTnI in a large cohort of healthy children.
Design and methods: As part of the LOOK study, blood was collected from a large cohort of healthy children on 3 separate occasions when the children were aged 8, 10 and 12 years. Samples were stored at -80 degrees C after collection and assayed after 1 freeze-thaw cycle using a pre-commercial release hs-cTnI assay from Abbott Diagnostics.
Results: More than 98% of the 12 year-old children had cTnI above the LoD of 1.0 ng/L. For the 212 boys the central 95% of results was distributed in a Gaussian fashion. For the 237 girls, the initial analysis was non-Gaussian, but after the elimination of 2 results, the pattern for girls was also Gaussian.
Conclusions: In healthy children, cTnI is present in a Gaussian distribution. Even minor illnesses can cause some troponin release, distorting this Gaussian distribution
Design and methods: As part of the LOOK study, blood was collected from a large cohort of healthy children on 3 separate occasions when the children were aged 8, 10 and 12 years. Samples were stored at -80 degrees C after collection and assayed after 1 freeze-thaw cycle using a pre-commercial release hs-cTnI assay from Abbott Diagnostics.
Results: More than 98% of the 12 year-old children had cTnI above the LoD of 1.0 ng/L. For the 212 boys the central 95% of results was distributed in a Gaussian fashion. For the 237 girls, the initial analysis was non-Gaussian, but after the elimination of 2 results, the pattern for girls was also Gaussian.
Conclusions: In healthy children, cTnI is present in a Gaussian distribution. Even minor illnesses can cause some troponin release, distorting this Gaussian distribution
| Original language | English |
|---|---|
| Pages (from-to) | 54-56 |
| Number of pages | 3 |
| Journal | Clinica Chimica Acta |
| Volume | 417 |
| DOIs | |
| Publication status | Published - 2013 |