@article{8981011963a24adea4a059e174e07255,
title = "The DNA methylome of inflammatory bowel disease (IBD) reflects intrinsic and extrinsic factors in intestinal mucosal cells",
abstract = "Abnormal DNA methylation has been described in human inflammatory conditions of the gastrointestinal tract, such as inflammatory bowel disease (IBD). As other complex diseases, IBD results from the balance between genetic predisposition and environmental exposures. As such, DNA methylation may be the consequence (and potential effector) of both, genetic susceptibility variants and/or environmental signals such as cytokine exposure. We attempted to discern between these two non-excluding possibilities by performing a combined analysis of published DNA methylation data in intestinal mucosal cells of IBD and control samples. We identified abnormal DNA methylation at different levels: deviation from mean methylation signals at site and region levels, and differential variability. A fraction of such changes is associated with genetic polymorphisms linked to IBD susceptibility. In addition, by comparing with another intestinal inflammatory condition (i.e., coeliac disease) we propose that aberrant DNA methylation can also be the result of unspecific processes such as chronic inflammation. Our characterization suggests that IBD methylomes combine intrinsic and extrinsic responses in intestinal mucosal cells, and could point to knowledge-based biomarkers of IBD detection and progression.",
keywords = "Adolescent, Adult, Aged, Child, DNA Methylation, Epigenome, Female, Humans, Inflammatory Bowel Diseases/genetics, Intestinal Mucosa/metabolism, Male, Middle Aged, Quantitative Trait Loci",
author = "Iolanda Agliata and Nora Fernandez-Jimenez and Chloe Goldsmith and Marie, {Julien C} and Bilbao, {Jose R} and Robert Dante and Hector Hernandez-Vargas",
note = "Funding Information: This work was supported by the Agence Nationale de Recherches sur le SIDA et les H?patites Virales [ANRS, Reference No. ECTZ47287 and ECTZ50137];?Institut National du Cancer (FR) [PLBIO 2017] (project: T cell tolerance to microbiota and colorectal cancers), and Ligue Contre le Cancer (FR) [AAP 2018]; NF is partially funded by the Basque Department of Health [project 2018/111086]. We thank the patients involved in the research and all researchers that deposited their data in open repositories. Publisher Copyright: {\textcopyright} 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. Funding Information: This work was supported by the Agence Nationale de Recherches sur le SIDA et les H{\'e}patites Virales [ANRS, Reference No. ECTZ47287 and ECTZ50137]; Institut National du Cancer (FR) [PLBIO 2017] (project: T cell tolerance to microbiota and colorectal cancers), and Ligue Contre le Cancer (FR) [AAP 2018]; NF is partially funded by the Basque Department of Health [project 2018/111086]. We thank the patients involved in the research and all researchers that deposited their data in open repositories. Publisher Copyright: {\textcopyright} 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.",
year = "2020",
month = oct,
doi = "10.1080/15592294.2020.1748916",
language = "English",
volume = "15",
pages = "1068--1082",
journal = "Epigenetics",
issn = "1559-2294",
publisher = "Landes Bioscience",
number = "10",
}
