Background/Aims: The calcium binding protein S100B has been associated with significant health effects in humans. Elevated circulating levels in later life cause neuronal apoptosis and brain inflammation, and has been associated with severe and chronic pathology including Alzheimer’s disease. The potential benefits of plant extracts on health have become more widely recognised and investigated. However, to date, their impact on S100B levels are not well defined. The aim of this systematic review was to identify candidate plant extracts and determine their effect on S100B levels in animal pre-clinical trials.