The effects of L-theanine and EGCG on Palmitic acid induced inflammation in mouse hypothalamic neuronal cell lines (mHypoE-N42)

Domenico Sergi, Lynda Williams, Jackson THOMAS, Duane MELLOR, Nenad NAUMOVSKI

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Background/Aims: The consumption of long-chain saturated fatty acids induces hypothalamic inflammation associated with insulin and leptin resistance. In contrast, bioactive compounds such as epigallocatechin gallate (EGCG) and L-theanine (L-THE) were reported to exhibit antioxidant and anti-inflammatory properties. This study determined the effect of EGCG on mitochondria morphology and L-THE on mitochondrial morphology and the expression of pro-inflammatory markers in cultured hypothalamic neurons (mHypoE-N42) after palmitic acid (PA) challenge.
Original languageEnglish
Pages (from-to)117-118
Number of pages2
JournalJournal of Nutrition and Intermediary Metabolism
Publication statusPublished - 2017


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