Background/Aims: The consumption of long-chain saturated fatty acids induces hypothalamic inflammation associated with insulin and leptin resistance. In contrast, bioactive compounds such as epigallocatechin gallate (EGCG) and L-theanine (L-THE) were reported to exhibit antioxidant and anti-inflammatory properties. This study determined the effect of EGCG on mitochondria morphology and L-THE on mitochondrial morphology and the expression of pro-inflammatory markers in cultured hypothalamic neurons (mHypoE-N42) after palmitic acid (PA) challenge.
Sergi, D., Williams, L., THOMAS, J., MELLOR, D., & NAUMOVSKI, N. (2017). The effects of L-theanine and EGCG on Palmitic acid induced inflammation in mouse hypothalamic neuronal cell lines (mHypoE-N42). Journal of Nutrition and Intermediary Metabolism, 8, 117-118. https://doi.org/10.1016/j.jnim.2017.04.216