The effects of L-theanine and EGCG on Palmitic acid induced inflammation in mouse hypothalamic neuronal cell lines (mHypoE-N42)

Domenico Sergi; Lynda Williams; Jackson THOMAS; Duane MELLOR; Nenad NAUMOVSKI

doi:10.1016/j.jnim.2017.04.216

The effects of L-theanine and EGCG on Palmitic acid induced inflammation in mouse hypothalamic neuronal cell lines (mHypoE-N42)

Domenico Sergi, Lynda Williams, Jackson THOMAS, Duane MELLOR, Nenad NAUMOVSKI

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Abstract

Background/Aims: The consumption of long-chain saturated fatty acids induces hypothalamic inflammation associated with insulin and leptin resistance. In contrast, bioactive compounds such as epigallocatechin gallate (EGCG) and L-theanine (L-THE) were reported to exhibit antioxidant and anti-inflammatory properties. This study determined the effect of EGCG on mitochondria morphology and L-THE on mitochondrial morphology and the expression of pro-inflammatory markers in cultured hypothalamic neurons (mHypoE-N42) after palmitic acid (PA) challenge.

Original language	English
Pages (from-to)	117-118
Number of pages	2
Journal	Journal of Nutrition and Intermediary Metabolism
Volume	8
DOIs	https://doi.org/10.1016/j.jnim.2017.04.216
Publication status	Published - 2017

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title = "The effects of L-theanine and EGCG on Palmitic acid induced inflammation in mouse hypothalamic neuronal cell lines (mHypoE-N42)",

abstract = "Background/Aims: The consumption of long-chain saturated fatty acids induces hypothalamic inflammation associated with insulin and leptin resistance. In contrast, bioactive compounds such as epigallocatechin gallate (EGCG) and L-theanine (L-THE) were reported to exhibit antioxidant and anti-inflammatory properties. This study determined the effect of EGCG on mitochondria morphology and L-THE on mitochondrial morphology and the expression of pro-inflammatory markers in cultured hypothalamic neurons (mHypoE-N42) after palmitic acid (PA) challenge.",

author = "Domenico Sergi and Lynda Williams and Jackson THOMAS and Duane MELLOR and Nenad NAUMOVSKI",

year = "2017",

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language = "English",

volume = "8",

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T1 - The effects of L-theanine and EGCG on Palmitic acid induced inflammation in mouse hypothalamic neuronal cell lines (mHypoE-N42)

AU - Sergi, Domenico

AU - Williams, Lynda

AU - THOMAS, Jackson

AU - MELLOR, Duane

AU - NAUMOVSKI, Nenad

PY - 2017

Y1 - 2017

N2 - Background/Aims: The consumption of long-chain saturated fatty acids induces hypothalamic inflammation associated with insulin and leptin resistance. In contrast, bioactive compounds such as epigallocatechin gallate (EGCG) and L-theanine (L-THE) were reported to exhibit antioxidant and anti-inflammatory properties. This study determined the effect of EGCG on mitochondria morphology and L-THE on mitochondrial morphology and the expression of pro-inflammatory markers in cultured hypothalamic neurons (mHypoE-N42) after palmitic acid (PA) challenge.

AB - Background/Aims: The consumption of long-chain saturated fatty acids induces hypothalamic inflammation associated with insulin and leptin resistance. In contrast, bioactive compounds such as epigallocatechin gallate (EGCG) and L-theanine (L-THE) were reported to exhibit antioxidant and anti-inflammatory properties. This study determined the effect of EGCG on mitochondria morphology and L-THE on mitochondrial morphology and the expression of pro-inflammatory markers in cultured hypothalamic neurons (mHypoE-N42) after palmitic acid (PA) challenge.

UR - https://www.mendeley.com/catalogue/54f4edf9-ff86-3d5d-bfb7-67e025db1de4/

U2 - 10.1016/j.jnim.2017.04.216

DO - 10.1016/j.jnim.2017.04.216

M3 - Meeting Abstract

SN - 2352-3859

VL - 8

SP - 117

EP - 118

JO - Journal of Nutrition and Intermediary Metabolism

JF - Journal of Nutrition and Intermediary Metabolism

ER -

The effects of L-theanine and EGCG on Palmitic acid induced inflammation in mouse hypothalamic neuronal cell lines (mHypoE-N42)

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