The Evolutionary History of Globin Genes: Insights from Marsupials and Monotremes

V Patel, Janine Deakin

    Research output: A Conference proceeding or a Chapter in BookChapter

    Abstract

    Haemoglobin, which is required for oxygen transportation in the blood, is encoded by members of the alpha (a) and beta (ß) globin gene families. They are highly regulated throughout different stages of development in a tissue-specific manner. The number and type of a- and ß-globin genes varies between jawed vertebrates. In teleosts and amphibians a- and ß-like globin genes are clustered together, but in birds and mammals these genes form distinct clusters on different chromosomes. This chapter reviews how data from marsupials and monotremes have contributed in discovering novel globin genes, which in turn has clarified how globin genes have evolved throughout amniote evolution. We also provide a detailed view of how the duplication of a single primordial globin gene (about 500 million years ago) along with other subsequent events have resulted in more complex a- and ß-globin clusters in extant vertebrates. In addition, how this has impacted the current fate and regulation of a- and ß-genes in mammals will also be discussed.
    Original languageEnglish
    Title of host publicationMarsupial Genetics and Genomics
    EditorsJ.E Deakin, P.D Waters, J.A.M Graves
    Place of PublicationNetherlands
    PublisherSpringer
    Pages415-433
    Number of pages19
    ISBN (Print)9789048190225
    DOIs
    Publication statusPublished - 2010

    Fingerprint

    Metatheria
    history
    genes
    vertebrates
    mammals
    amphibians
    hemoglobin
    chromosomes
    oxygen
    birds
    blood

    Cite this

    Patel, V., & Deakin, J. (2010). The Evolutionary History of Globin Genes: Insights from Marsupials and Monotremes. In J. E. Deakin, P. D. Waters, & J. A. M. Graves (Eds.), Marsupial Genetics and Genomics (pp. 415-433). Netherlands: Springer. https://doi.org/10.1007/978-90-481-9023-2_20
    Patel, V ; Deakin, Janine. / The Evolutionary History of Globin Genes: Insights from Marsupials and Monotremes. Marsupial Genetics and Genomics. editor / J.E Deakin ; P.D Waters ; J.A.M Graves. Netherlands : Springer, 2010. pp. 415-433
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    abstract = "Haemoglobin, which is required for oxygen transportation in the blood, is encoded by members of the alpha (a) and beta ({\ss}) globin gene families. They are highly regulated throughout different stages of development in a tissue-specific manner. The number and type of a- and {\ss}-globin genes varies between jawed vertebrates. In teleosts and amphibians a- and {\ss}-like globin genes are clustered together, but in birds and mammals these genes form distinct clusters on different chromosomes. This chapter reviews how data from marsupials and monotremes have contributed in discovering novel globin genes, which in turn has clarified how globin genes have evolved throughout amniote evolution. We also provide a detailed view of how the duplication of a single primordial globin gene (about 500 million years ago) along with other subsequent events have resulted in more complex a- and {\ss}-globin clusters in extant vertebrates. In addition, how this has impacted the current fate and regulation of a- and {\ss}-genes in mammals will also be discussed.",
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    Patel, V & Deakin, J 2010, The Evolutionary History of Globin Genes: Insights from Marsupials and Monotremes. in JE Deakin, PD Waters & JAM Graves (eds), Marsupial Genetics and Genomics. Springer, Netherlands, pp. 415-433. https://doi.org/10.1007/978-90-481-9023-2_20

    The Evolutionary History of Globin Genes: Insights from Marsupials and Monotremes. / Patel, V; Deakin, Janine.

    Marsupial Genetics and Genomics. ed. / J.E Deakin; P.D Waters; J.A.M Graves. Netherlands : Springer, 2010. p. 415-433.

    Research output: A Conference proceeding or a Chapter in BookChapter

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    N2 - Haemoglobin, which is required for oxygen transportation in the blood, is encoded by members of the alpha (a) and beta (ß) globin gene families. They are highly regulated throughout different stages of development in a tissue-specific manner. The number and type of a- and ß-globin genes varies between jawed vertebrates. In teleosts and amphibians a- and ß-like globin genes are clustered together, but in birds and mammals these genes form distinct clusters on different chromosomes. This chapter reviews how data from marsupials and monotremes have contributed in discovering novel globin genes, which in turn has clarified how globin genes have evolved throughout amniote evolution. We also provide a detailed view of how the duplication of a single primordial globin gene (about 500 million years ago) along with other subsequent events have resulted in more complex a- and ß-globin clusters in extant vertebrates. In addition, how this has impacted the current fate and regulation of a- and ß-genes in mammals will also be discussed.

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    Patel V, Deakin J. The Evolutionary History of Globin Genes: Insights from Marsupials and Monotremes. In Deakin JE, Waters PD, Graves JAM, editors, Marsupial Genetics and Genomics. Netherlands: Springer. 2010. p. 415-433 https://doi.org/10.1007/978-90-481-9023-2_20